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A previous study reported decreased levels of serum sulfatides in hemodialysis patients and suggested an association with cardiovascular disease. However, the mechanism of changes in serum sulfatides in chronic kidney dysfunction has not been well investigated. The current study examined whether a chronic kidney disease (CKD) state could decrease serum sulfatide levels using 5/6 nephrectomy (5/6NCKD) mice, an established CKD murine model, and studied the mechanisms contributing to diminished sulfatides. 5/6NCKD mice and sham operation control mice were sacrificed at the 4th or 12th postoperative week (POW) for measurement of serum sulfatide levels. Hepatic sulfatide content, which is the origin of serum sulfatides, and the expression of sulfatide metabolic enzymes in liver tissue were assessed as well. The 5/6NCKD mice developed CKD and showed increased serum creatinine and indoxyl sulfate. The serum levels and hepatic amounts of sulfatides were significantly decreased in 5/6NCKD mice at both 4 and 12 POW, while the degradative enzymes of sulfatides arylsulfatase A and galactosylceramidase were significantly increased. In a Hepa1-6 murine liver cell line, indoxyl sulfate addition caused intracellular levels of sulfatides to decrease and degradative enzymes of sulfatides to increase in a manner comparable to the changes in 5/6NCKD mice liver tissue. In conclusion, chronic kidney dysfunction causes degradation of sulfatides in the liver to decrease serum sulfatide levels. 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Impact of Chronic Kidney Dysfunction on Serum Sulfatides and Its Metabolic Pathway in Mice(マウスにおける慢性腎機能障害が血清スルファチドとその代謝経路に与える影響)
http://hdl.handle.net/10091/00021503
http://hdl.handle.net/10091/00021503684d9e26-94ff-4dcd-864d-0d4ca489bfcf
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-06-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Impact of Chronic Kidney Dysfunction on Serum Sulfatides and Its Metabolic Pathway in Mice(マウスにおける慢性腎機能障害が血清スルファチドとその代謝経路に与える影響) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
山田, 洋輔
× 山田, 洋輔 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 山田 洋輔. Impact of Chronic Kidney Dysfunction on Serum Sulfatides and Its Metabolic Pathway in Mice(マウスにおける慢性腎機能障害が血清スルファチドとその代謝経路に与える影響). 信州大学, 2018, 博士論文. | |||||
書誌情報 |
発行日 2018-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1162号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1162号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。GLYCOCONJUGATE JOURNAL. 36(1):1-11 (2019); doi:10.1007/s10719-018-9850-7. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/30536036/ | |||||
関連名称 | 30536036 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10719-018-9850-7 | |||||
関連名称 | 10.1007/s10719-018-9850-7 | |||||
権利 | ||||||
権利情報 | The final publication is available at www.springerlink.com | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000457603500001 |