{"_buckets": {"deposit": "6ae7f39b-d050-4d6d-8c85-2918d36dd9b5"}, "_deposit": {"id": "20755", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20755"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020755", "sets": ["849"]}, "author_link": ["108091"], "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "信州大学(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_14_description_26": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "雑誌に発表。JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 39(5-6):163-173 (2018); doi:10.1007/s10974-019-09504-2.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "小松　雅俊. Increase in phospholamban content in mouse skeletal muscle after denervation（除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加）. 信州大学, 2018, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601甲第1172号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000466555500003"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30806861"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=30806861", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s10974-019-09504-2"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s10974-019-09504-2", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at link.springer.com"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "甲第1172号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Denervation; Skeletal muscle; Sarcoplasmic/endoplasmic calcium ATPase; Phospholamban"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SARCOPLASMIC-RETICULUM; FAST-TWITCH; CYCLOPIAZONIC ACID; CA2+ STORAGE; EXPRESSION; SLOW; FIBERS; OVEREXPRESSION; DEGRADATION; SARCOLIPIN"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "It is well-known that denervation of motor nerves induces atrophy and decreases contractile force of the skeletal muscle. However, it is not completely understood how denervation alters calcium handling in the skeletal muscle. We investigated the effect of denervation on the expression and function of proteins involved in calcium handling. Two weeks after denervation of the right sciatic nerve in mice, we observed a significant decrease in mass and cross-sectional area of the ipsilateral tibialis anterior (TA) and flexor digitorum brevis (FDB) muscles. Also, we observed a significant decrease in the specific tetanus contractile force in the ipsilateral TA muscle. Calcium imaging of the ipsilateral FDB showed that the peak twitch and tetanus calcium concentrations were significantly decreased due to a decrease in calcium content of the sarcoplasmic reticulum (SR). Denervation reduced the maximum rate of sarcoplasmic/endoplasmic calcium ATPase (SERCA) activity. Interestingly, the amount of phospholamban (PLN), but not its transcripts, was increased in the ipsilateral vs. contralateral side after denervation, suggesting that denervation impairs constitutive regulation of PLN. Immunohistochemical analysis revealed increased PLN in all major fiber types in TA with IIx fibers showing a threefold higher expression than the contralateral side. These results suggest that the abnormal increase in PLN in the ipsilateral fast-twitch fibers may be involved in decreased SERCA activity, SR calcium content, peak calcium transients, and contractile forces of denervated muscles."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小松, 雅俊"}], "nameIdentifiers": [{"nameIdentifier": "108091", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "13MH019C_yoshi.pdf", "filesize": [{"value": "133.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 133800.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20755/files/13MH019C_yoshi.pdf"}, "version_id": "b5b8e90e-6fa6-4c1d-ba0f-c363e5aa3ba3"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "13MH019C_shinsa.pdf", "filesize": [{"value": "107.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 107000.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20755/files/13MH019C_shinsa.pdf"}, "version_id": "a876aee0-1d4a-46d8-a57d-c899529382b5"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "13MH019C_ronbun.pdf", "filesize": [{"value": "803.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "The final publication is available at link.springer.com", "licensetype": "license_note", "mimetype": "application/pdf", "size": 803700.0, "url": {"label": "博士論文の全文", "url": "https://soar-ir.repo.nii.ac.jp/record/20755/files/13MH019C_ronbun.pdf"}, "version_id": "82dd7094-eddc-4f3c-a366-3a8251922e1d"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Increase in phospholamban content in mouse skeletal muscle after denervation（除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Increase in phospholamban content in mouse skeletal muscle after denervation（除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加）", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00021513", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20755", "relation": {}, "relation_version_is_last": true, "title": ["Increase in phospholamban content in mouse skeletal muscle after denervation（除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加）"], "weko_shared_id": -1}