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Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる). 信州大学, 2018, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601乙第1222号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000456388700012"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30341732"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/30341732/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00204-018-2335-4"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00204-018-2335-4", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at link.springer.com"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "乙第1222号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "High-cholesterol diet; Peroxisome proliferator-activated receptor (PPAR); Coagulation factors; Cardiovascular diseases; Sulfatides"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CONVERTING ENZYME-INHIBITORS; PPAR-ALPHA PROTECTS; TISSUE FACTOR; OXIDATIVE STRESS; EXPRESSION; LIVER; GENE; METABOLISM; FIBRINOLYSIS; ATHEROSCLEROSIS"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Peroxisome proliferator-activated receptor (PPAR) is involved in the regulation of fatty acid and cholesterol metabolism. A high-cholesterol (HC) diet increases the risk of developing cardiovascular diseases (CVD); however, it is unclear whether the toxic effects of cholesterol involve changes in thrombotic factor expression, and whether PPAR is necessary for such effects. To investigate this possibility, we fed a HC diet to wild-type (WT) and Ppara-null mice and measured cholesterol and triglyceride contents, liver histology, serum/plasma levels of coagulation factors, hepatic expression of the coagulation factors, liver/serum sulfatide levels, hepatic sulfatide metabolism, hepatic expression of lipid transporters, and hepatic oxidative stress and its relating enzymes. In Ppara-null mice, the HC diet caused triglyceride accumulation and exacerbated inflammation and oxidative stress in liver, increased levels of coagulation factors, including tissue factor, plasminogen activator inhibitor-1 and carboxypeptidase B2 in blood and liver, and decreased levels of anti-thrombotic sulfatides in serum and liver. These changes were much less marked in WT mice. These findings imply that cholesterol overload exerts its toxic effects at least in part by enhancing thrombosis, secondary to abnormal hepatic lipid metabolism, inflammation, and oxidative stress. Moreover, we reveal for the first time that PPAR can attenuate these toxic effects by transcriptional regulation of coagulation factors and sulfatides, in addition to its known effects of controlling lipid homeostasis and suppressing inflammation and oxidative stress. Therapies aimed at activating PPAR might prevent HC diet-induced CVD through modulating various pro- and anti-thrombotic factors."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "盧, 郁", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "108102", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "18MR0007_yoshi.pdf", "filesize": [{"value": "138.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 138600.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_yoshi.pdf"}, "version_id": "b9ad9a11-f843-429d-ab34-cead7ba55ceb"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "18MR0007_shinsa.pdf", "filesize": [{"value": "94.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 94900.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_shinsa.pdf"}, "version_id": "10791c70-83f6-4e68-a161-b219a422468c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-10-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "18MR0007_ronbun.pdf", "filesize": [{"value": "766.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "The final publication is available at link.springer.com", "licensetype": "license_note", "mimetype": "application/pdf", "size": 766600.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_ronbun.pdf"}, "version_id": "32954ad3-95b5-4be1-af04-68c45360d1fe"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00021524", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20766", "relation": {}, "relation_version_is_last": true, "title": ["Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)"], "weko_shared_id": -1}
Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)
http://hdl.handle.net/10091/00021524
http://hdl.handle.net/10091/000215242ab31d45-3eeb-4219-bb74-1907ceedda27
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内容の要旨 (138.6 kB)
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審査結果の要旨 (94.9 kB)
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博士論文の全文 (766.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-06-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
盧, 郁
× 盧, 郁 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 盧 郁. Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる). 信州大学, 2018, 博士論文. | |||||
書誌情報 |
発行日 2018-12-26 |
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学位授与番号 | ||||||
学位授与番号 | 13601乙第1222号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2018-12-26 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
乙第1222号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。ARCHIVES OF TOXICOLOGY. 93(1):149-161 (2019); doi:10.1007/s00204-018-2335-4. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/30341732/ | |||||
関連名称 | 30341732 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00204-018-2335-4 | |||||
関連名称 | 10.1007/s00204-018-2335-4 | |||||
権利 | ||||||
権利情報 | The final publication is available at link.springer.com | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000456388700012 |