ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "e7527a5c-943f-4224-b50b-b3a32dc260bb"}, "_deposit": {"id": "20766", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20766"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00020766", "sets": []}, "author_link": ["108102"], "item_14_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-12-26", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2018-12-26"}]}, "item_14_degree_grantor_10": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u4fe1\u5dde\u5927\u5b66(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_14_description_26": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u96d1\u8a8c\u306b\u767a\u8868\u3002ARCHIVES OF TOXICOLOGY. 93(1):149-161 (2019); doi:10.1007/s00204-018-2335-4.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "\u76e7\u3000\u90c1. Peroxisome proliferator-activated receptor \u03b1 attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u306f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u98df\u8a98\u5c0e\u6bd2\u6027\u3068\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u3092\u6e1b\u5f31\u3055\u305b\u308b\uff09. \u4fe1\u5dde\u5927\u5b66, 2018, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u4e59\u7b2c1222\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000456388700012"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30341732"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=30341732", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00204-018-2335-4"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00204-018-2335-4", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at link.springer.com"}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u4e59\u7b2c1222\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "High-cholesterol diet; Peroxisome proliferator-activated receptor (PPAR); Coagulation factors; Cardiovascular diseases; Sulfatides"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CONVERTING ENZYME-INHIBITORS; PPAR-ALPHA PROTECTS; TISSUE FACTOR; OXIDATIVE STRESS; EXPRESSION; LIVER; GENE; METABOLISM; FIBRINOLYSIS; ATHEROSCLEROSIS"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Peroxisome proliferator-activated receptor (PPAR) is involved in the regulation of fatty acid and cholesterol metabolism. A high-cholesterol (HC) diet increases the risk of developing cardiovascular diseases (CVD); however, it is unclear whether the toxic effects of cholesterol involve changes in thrombotic factor expression, and whether PPAR is necessary for such effects. To investigate this possibility, we fed a HC diet to wild-type (WT) and Ppara-null mice and measured cholesterol and triglyceride contents, liver histology, serum/plasma levels of coagulation factors, hepatic expression of the coagulation factors, liver/serum sulfatide levels, hepatic sulfatide metabolism, hepatic expression of lipid transporters, and hepatic oxidative stress and its relating enzymes. In Ppara-null mice, the HC diet caused triglyceride accumulation and exacerbated inflammation and oxidative stress in liver, increased levels of coagulation factors, including tissue factor, plasminogen activator inhibitor-1 and carboxypeptidase B2 in blood and liver, and decreased levels of anti-thrombotic sulfatides in serum and liver. These changes were much less marked in WT mice. These findings imply that cholesterol overload exerts its toxic effects at least in part by enhancing thrombosis, secondary to abnormal hepatic lipid metabolism, inflammation, and oxidative stress. Moreover, we reveal for the first time that PPAR can attenuate these toxic effects by transcriptional regulation of coagulation factors and sulfatides, in addition to its known effects of controlling lipid homeostasis and suppressing inflammation and oxidative stress. Therapies aimed at activating PPAR might prevent HC diet-induced CVD through modulating various pro- and anti-thrombotic factors."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u76e7, \u90c1"}], "nameIdentifiers": [{"nameIdentifier": "108102", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "18MR0007_yoshi.pdf", "filesize": [{"value": "138.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 138600.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_yoshi.pdf"}, "version_id": "b9ad9a11-f843-429d-ab34-cead7ba55ceb"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "18MR0007_shinsa.pdf", "filesize": [{"value": "94.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 94900.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_shinsa.pdf"}, "version_id": "10791c70-83f6-4e68-a161-b219a422468c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-10-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "18MR0007_ronbun.pdf", "filesize": [{"value": "766.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "The final publication is available at link.springer.com", "licensetype": "license_note", "mimetype": "application/pdf", "size": 766600.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/20766/files/18MR0007_ronbun.pdf"}, "version_id": "32954ad3-95b5-4be1-af04-68c45360d1fe"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Peroxisome proliferator-activated receptor \u03b1 attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u306f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u98df\u8a98\u5c0e\u6bd2\u6027\u3068\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u3092\u6e1b\u5f31\u3055\u305b\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Peroxisome proliferator-activated receptor \u03b1 attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u306f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u98df\u8a98\u5c0e\u6bd2\u6027\u3068\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u3092\u6e1b\u5f31\u3055\u305b\u308b\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00021524", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20766", "relation": {}, "relation_version_is_last": true, "title": ["Peroxisome proliferator-activated receptor \u03b1 attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice\uff08\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u306f\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u98df\u8a98\u5c0e\u6bd2\u6027\u3068\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u3092\u6e1b\u5f31\u3055\u305b\u308b\uff09"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)

http://hdl.handle.net/10091/00021524
2ab31d45-3eeb-4219-bb74-1907ceedda27
名前 / ファイル ライセンス アクション
18MR0007_yoshi.pdf 内容の要旨 (138.6 kB)
18MR0007_shinsa.pdf 審査結果の要旨 (94.9 kB)
18MR0007_ronbun.pdf 博士論文の全文 (766.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-06-14
タイトル
言語 en
タイトル Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 盧, 郁

× 盧, 郁

WEKO 108102

盧, 郁

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 盧 郁. Peroxisome proliferator-activated receptor α attenuates high- cholesterol diet-induced toxicity and pro-thrombotic effects in mice(ペルオキシソーム増殖剤活性化受容体αはマウスにおける高コレステロール食誘導毒性と血栓形成促進性を減弱させる). 信州大学, 2018, 博士論文.
書誌情報
発行日 2018-12-26
学位授与番号
学位授与番号 13601乙第1222号
学位授与年月日
学位授与年月日 2018-12-26
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
乙第1222号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。ARCHIVES OF TOXICOLOGY. 93(1):149-161 (2019); doi:10.1007/s00204-018-2335-4.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=30341732
関連名称
関連名称 30341732
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00204-018-2335-4
関連名称
関連名称 10.1007/s00204-018-2335-4
権利
権利情報 The final publication is available at link.springer.com
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000456388700012
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 07:47:22.936834
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio