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"}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "乙第1226号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "transient receptor potential vanilloid subfamily 2; bone cancer pain; movement-related pain; small interference RNA"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CAPSAICIN-RECEPTOR HOMOLOG; SYSTEMIC MORPHINE; HIGH-THRESHOLD; PAIN; EXPRESSION; NOCICEPTORS; MECHANISMS"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Bone cancer pain is a complex pain state involving ongoing pain and movement-related pain, which are thought to be caused by different mechanisms. Transient receptor potential vanilloid subfamily 1 (TRPV1) is involved in ongoing pain but not movement-related pain. The purpose of this study was to investigate the role of transient receptor potential vanilloid subfamily 2 (TRPV2) in bone cancer pain. Proportions of TRPV1- and TRPV2-immunoreactive neurons in lumbar dorsal root ganglia innervating the femurs of male mice were examined by using Fluoro-Gold. Mice were intrathecally injected with small interfering RNA (siRNA) against TRPV2 or scrambled siRNA for three consecutive days from day 14 after sarcoma injection into the left femur. In the mice with bone cancer, the number of spontaneous flinches was quantified for assessment of ongoing pain, and limb use and weight bearing were assessed as indications of movement-related pain. Changes in TRPV2 protein levels in dorsal root ganglion were evaluated by Western blotting. We also examined the effects of intrathecal administration of siRNA against TRPV2 or scrambled siRNA on thermal and mechanical sensitivities in normal mice without tumors. The proportions of TRPV1-immunoreactive and TRPV2-immunoreactive neurons were 21% and 22% of neurons in dorsal root ganglia innervating the femur, respectively. Tumor-bearing mice exhibited an increased number of spontaneous flinches and impaired limb use and weight bearing at day 13 after sarcoma injection. TRPV2 protein level in dorsal root ganglia at day 13 was comparable to that at baseline. siRNA against TRPV2 significantly improved limb use and weight bearing but did not affect the number of spontaneous flinches compared to those in the group treated with scrambled siRNA. siRNA against TRPV2 did not affect thermal or mechanical sensitivity in normal mice. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Knockdown of TRPV2 channels in sensory neurons increases limb use and weight bearing but dose not affect spontaneous flinching behavior in a mouse model of bone cancer.(一次知覚神経のTransient Receptor Potential Vanilloid Subfamily 2チャネルのノックダウンは、マウス骨がんモデルにおける自発痛には影響せず、体動時痛のみを改善する)

http://hdl.handle.net/10091/00021528
http://hdl.handle.net/10091/00021528
2f41fd93-8e14-4d3f-b3c0-c55d2738d1de
名前 / ファイル ライセンス アクション
18MR0010_yoshi.pdf 内容の要旨 (78.7 kB)
18MR0010_shinsa.pdf 審査結果の要旨 (67.5 kB)
18MR0010_ronbun.pdf 博士論文の全文 (828.6 kB)
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Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-06-14
タイトル
言語 en
タイトル Knockdown of TRPV2 channels in sensory neurons increases limb use and weight bearing but dose not affect spontaneous flinching behavior in a mouse model of bone cancer.(一次知覚神経のTransient Receptor Potential Vanilloid Subfamily 2チャネルのノックダウンは、マウス骨がんモデルにおける自発痛には影響せず、体動時痛のみを改善する)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 山本, 克己

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WEKO 108106

ja 山本, 克己

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 山本 克己. Knockdown of TRPV2 channels in sensory neurons increases limb use and weight bearing but dose not affect spontaneous flinching behavior in a mouse model of bone cancer.(一次知覚神経のTransient Receptor Potential Vanilloid Subfamily 2チャネルのノックダウンは、マウス骨がんモデルにおける自発痛には影響せず、体動時痛のみを改善する). 信州大学, 2019, 博士論文.
書誌情報
発行日 2019-03-13
学位授与番号
学位授与番号 13601乙第1226号
学位授与年月日
学位授与年月日 2019-03-13
学位名
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13601
学位授与機関名 信州大学(Shinshu university)
学位の区分
doctoral
学位の分野
医学
学位の報告番号
乙第1226号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。MOLECULAR PAIN. 14:(2018); doi:10.1177/1744806918819942.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1177/1744806918819942
関連名称 10.1177/1744806918819942
権利
権利情報 © The Author(s) 2018 / This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000454196200001
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