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The contribution of genetic variants of the gene encoding peroxisome proliferator-activated receptor-alpha gene (PPARA) to high-altitude hypoxia adaptation in Sherpa highlanders. High Alt Med Biol. 16:000-000, 2018.-Sherpa highlanders, who play invaluable roles in the exploration of Mount Everest, have exceptional tolerance to hypobaric hypoxia. Sherpa people are well known to possess the traits determined by genetic background for high-altitude adaptation. The metabolic adaptation mechanism is one of the biological ways for Sherpa highlanders in protecting them from hypoxia stress at high altitude. Studies have suggested that the gene encoding PPARA is associated with metabolic adaptation in the Himalayan population of Tibetans. This study attempts to investigate the genetic variants of the PPARA in Sherpa highlanders and the association with high-altitude hypoxia adaptation. Seven single-nucleotide polymorphisms (SNPs; rs135547, rs5769178, rs881740, rs4253712, rs5766741, and rs5767700 in introns and rs1800234 in exon 6) in the PPARA were genotyped in 105 Sherpa highlanders who lived in the Khumbu region (3440 m above sea level) and 111 non-Sherpa lowlanders who resided in Kathmandu (1300 m) in Nepal. By means of analyses of genetic distances, genotype distributions, allele frequencies, linkage disequilibrium, and haplotype constructions of the seven SNPs in the Sherpa highlanders versus the non-Sherpa lowlanders, it was revealed that the frequencies of minor alleles of rs4253712, rs5766741, rs5767700, and rs1800234 SNPs, as well as the frequency of haplotype constructed by the minor alleles of rs5766741-rs5767700-rs1800234, were significantly overrepresented in the Sherpa highlanders in comparison with the non-Sherpa lowlanders. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

The contribution of genetic variants of the peroxisome proliferator-activated receptor-alpha gene to high-altitude hypoxia adaptation in Sherpa highlanders(シェルパ高地民族の高所低酸素適応におけるペルオキシソーム増殖剤活性化受容体α遺伝子変異の関与)

http://hdl.handle.net/10091/00021529
336072aa-ee23-48f8-9013-3a973d3b75f6
名前 / ファイル ライセンス アクション
18MR0013_yoshi.pdf 内容の要旨 (161.1 kB)
18MR0013_shinsa.pdf 審査結果の要旨 (242.7 kB)
18MR0013_ronbun.pdf 博士論文の全文 (167.4 kB)
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Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-08-06
タイトル
言語 en
タイトル The contribution of genetic variants of the peroxisome proliferator-activated receptor-alpha gene to high-altitude hypoxia adaptation in Sherpa highlanders(シェルパ高地民族の高所低酸素適応におけるペルオキシソーム増殖剤活性化受容体α遺伝子変異の関与)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 木野田, 文也

× 木野田, 文也

WEKO 108107

木野田, 文也

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 木野田 文也. The contribution of genetic variants of the peroxisome proliferator-activated receptor-alpha gene to high-altitude hypoxia adaptation in Sherpa highlanders(シェルパ高地民族の高所低酸素適応におけるペルオキシソーム増殖剤活性化受容体α遺伝子変異の関与). 信州大学, 2019, 博士論文.
書誌情報
発行日 2019-03-27
学位授与番号
学位授与番号 13601乙第1227号
学位授与年月日
学位授与年月日 2019-03-27
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
乙第1227号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。HIGH ALTITUDE MEDICINE & BIOLOGY. (2018); doi:10.1089/ham.2018.0052.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=30475063
関連名称
関連名称 30475063
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1089/ham.2018.0052
関連名称
関連名称 10.1089/ham.2018.0052
権利
権利情報 © Fumiya Kinota et al. 2018; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000451143100001
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