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Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells
http://hdl.handle.net/10091/00021596
http://hdl.handle.net/10091/00021596783ad1ee-a291-4af3-998c-04f3a3771fad
| 名前 / ファイル | ライセンス | アクション |
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26293369_05.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2019-09-09 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1242/bio.20147799 | |||||||||||||||||
| 関連名称 | 10.1242/bio.20147799 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Occludin, Deafness, Tight junction, Cochlea, Hair cell, Tricellulin | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Kitajiri, Shin-ichiro
× Kitajiri, Shin-ichiro
× Katsuno, Tatsuya
× Sasaki, Hiroyuki
× Ito, Juichi
× Furuse, Mikio
× Tsukita, Shoichiro
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Kitajiri, Shin-ichiro | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jUTCupyC.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | COMPANY OF BIOLOGISTS LTD | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | BIOLOGY OPEN.3(8):759-766(2014) | |||||||||||||||||
| 書誌情報 |
BIOLOGY OPEN 巻 3, 号 8, p. 759-766, 発行日 2014-08-15 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Occludin is the first identified protein in the tight junction (TJ), but its function has remained for the most part obscure. TJs have been demonstrated to play important roles in the inner ear function, and occludin is expressed in all the epithelial TJs in the inner ear. Thus, we examined the inner ears of occludin-deficient (Occ(-/-)) mice. Although inner ears initially developed normally in Occ(-/-) mice, apoptosis occurs in hair cells in the organ of Corti around day 12 after birth, and deafness develops. Since hair cell degeneration was not observed in cochlear explant cultures of Occ(-/-) mice, environmental changes were considered to be the trigger of cell death. As for the vestibular system, both the morphologies and functions are normal in Occ(-/-) mice. These phenotypes of Occ(-/-) mice are very similar with those of claudin-14 or claudin-9 deficient mice, leading us to speculate on the existence of imbalance induced by TJ abnormalities, such as localized ionic components. Moreover, the occludin deficiency led to dislocalization of tricellulin, a gene responsible for human deafness DFNB49. The deafness in Occ(-/-) mice may be due to this dislocalization of tricellulin. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 2046-6390 | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/25063198 | |||||||||||||||||
| 関連名称 | 25063198 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | © 2014. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
| WoS | ||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348069900008 | |||||||||||||||||
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Kitajiri, Shin-ichiro, Katsuno, Tatsuya, Sasaki, Hiroyuki, Ito, Juichi, Furuse, Mikio, Tsukita, Shoichiro, 2014, Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells: COMPANY OF BIOLOGISTS LTD, 759–766 p.
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