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Acetyl-L-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract
http://hdl.handle.net/10091/00021598
http://hdl.handle.net/10091/00021598ff084bf0-0894-448b-a55b-55a4a3cdbfff
| 名前 / ファイル | ライセンス | アクション |
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15K08131_01.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2019-09-09 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Acetyl-L-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.neulet.2017.06.001 | |||||||||||||||
| 関連名称 | 10.1016/j.neulet.2017.06.001 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Olfactory tract injury, Spontaneous regeneration, Acetyl-l-carnitine, Myelinated axons, Neonatal rats | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
Fukushima, Nanae
× Fukushima, Nanae
× Yokouchi, Kumiko
× Kuroiwa, Masafumi
× Kawagishi, Kyutaro
× Moriizumi, Tetsuji
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| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | Fukushima, Nanae | |||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yCkpuakh.html | |||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | Moriizumi, Tetsuji | |||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gVcVZVkC.html | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | ELSEVIER IRELAND LTD | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | NEUROSCIENCE LETTERS.653:215-219(2017) | |||||||||||||||
| 書誌情報 |
NEUROSCIENCE LETTERS 巻 653, p. 215-219, 発行日 2017-06-03 |
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| 抄録 | ||||||||||||||||
| 内容記述 | It is well known that acetyl-L-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats. (C) 2017 Elsevier B.V. All rights reserved. | |||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0304-3940 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00754925 | |||||||||||||||
| PubMed | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/28583580 | |||||||||||||||
| 関連名称 | 28583580 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| WoS | ||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000405153900035 | |||||||||||||||
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Fukushima, Nanae, Yokouchi, Kumiko, Kuroiwa, Masafumi, Kawagishi, Kyutaro, Moriizumi, Tetsuji, 2017, Acetyl-L-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract: ELSEVIER IRELAND LTD, 215–219 p.
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