| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-09-09 |
| タイトル |
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タイトル |
Clinical Characteristics and Predictors of Mortality in Patients with Combined Pulmonary Fibrosis and Emphysema Syndrome and Lung Cancer |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.4172/2161-105X.1000263 |
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関連名称 |
10.4172/2161-105X.1000263 |
| キーワード |
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主題 |
CPFE, Emphysema, Pulmonary fibrosis, Lung cancer, KL-6 |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Kitaguchi, Yoshiaki
Fujimoto, Keisaku
Hotta, Junichi
Horie, Shiro
Hirayama, Jiro
Hanaoka, Masayuki
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| 信州大学研究者総覧へのリンク |
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氏名 |
Kitaguchi, Yoshiaki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.PUyCbhym.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
Fujimoto, Keisaku |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
Hanaoka, Masayuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html |
| 出版者 |
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出版者 |
OMICS International |
| 引用 |
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内容記述 |
Journal of Pulmonary and Respiratory Medicine.5(3):263(2015) |
| 書誌情報 |
Journal of Pulmonary and Respiratory Medicine
巻 5,
号 3,
p. 263,
発行日 2015-05-22
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| 抄録 |
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内容記述 |
Rationale: We performed this retrospective study to clarify the clinical characteristics, survival and mortality predictors in patients with combined pulmonary fibrosis and emphysema (CPFE) and lung cancer. Methods: We retrospectively reviewed the medical records of a total of 123 patients with lung cancer, as confirmed according to histological or cytological examinations. Based on the findings of chest CT, the patients were categorized into four groups: LC+normal (n=70); LC+emphysema (n=26); LC+fibrosis (n=10); LC+CPFE (n=17). The clinical characteristics and survival of the LC+CPFE group were compared with those of the other groups. In addition, mortality predictors were evaluated in the LC+CPFE group. Results: The proportion of females was significantly higher in the LC+normal group than in the LC+CPFE and LC+emphysema groups. Significantly more patients were diagnosed with squamous cell carcinoma in the LC+CPFE group than in the LC+normal group. The proportion of patients whose primary mass was located in “nonsubpleural” areas was significantly higher in patients with CPFE who also had lung cancer in the upper lobe than in those with CPFE who also had lung cancer in the other sites. There were significant differences in survival between the LC+normal group and the other groups, whereas there were no significant differences in survival among the LC+emphysema, LC+fibrosis and LC+CPFE groups. In the LC+CPFE group, the patients with a high level of serum KL-6 at diagnosis and upper lobe lung cancer demonstrated a high risk of death. A high level of serum KL-6 at diagnosis was also independently associated with a high risk of death. Conclusions: Patients with CPFE and lung cancer may have distinct clinical characteristics. Strict follow-up is required in patients with CPFE and lung cancer whose serum KL-6 level at diagnosis is higher than the normal range and/or the primary mass of lung cancer is located in the upper lobe. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2161-105X |
| 権利 |
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権利情報 |
© 2015 Kitaguchi Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
15K01281_07.pdf (536.9 kB)
