| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-09-09 |
| タイトル |
|
|
タイトル |
Expression of 5-Hydroxytryptamine Receptors in Human Urinary Bladders with Benign Prostatic Hyperplasia |
| 言語 |
|
|
言語 |
eng |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.1007/s12325-015-0242-0 |
|
|
関連名称 |
10.1007/s12325-015-0242-0 |
| キーワード |
|
|
主題 |
5-Hydroxytryptamine receptor, Detrusor, Human, Urinary bladder, Urothelium |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Imamura, Tetsuya
Ishizuka, Osamu
Ogawa, Teruyuki
Minagawa, Tomonori
Ishikawa, Masakuni
Hiragata, Shiro
Yokoyama, Hitoshi
Nakazawa, Masaki
Kurizaki, Yoshiki
Nishizawa, Osamu
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Imamura, Tetsuya |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Ishizuka, Osamu |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Ogawa, Teruyuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Minagawa, Tomonori |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Nishizawa, Osamu |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html |
| 出版者 |
|
|
出版者 |
SPRINGER |
| 引用 |
|
|
内容記述 |
ADVANCES IN THERAPY.32:S29-S37(2015) |
| 書誌情報 |
ADVANCES IN THERAPY
巻 32,
p. S29-S37,
発行日 2015-09-21
|
| 抄録 |
|
|
内容記述 |
Introduction: This study investigated the mRNA expression pattern and distribution of 5-hydroxytryptamine (5-HT) receptors 5-HT2A, 5-HT2B, 5-HT3A, 5-HT4, and 5-HT7 within the urothelium and detrusor of normal bladder tissue and in the urothelium of bladders from patients with benign prostatic hyperplasia (BPH). Methods: Normal urinary bladder specimens were obtained from 13 patients undergoing radical cystectomy due to bladder cancer (normal group) and BPH specimens were obtained from 27 benign prostatic obstruction patients receiving transurethral prostatectomy or retropubic prostatectomy. Receptor subtype mRNA expression was determined by real-time reverse transcription polymerase chain reaction on urothelium, detrusor, and whole mucosal preparations. Receptor distribution was determined by immunohistochemistry. Results: In normal tissues, expressions of 5-HT2B and 5-HT7 receptor mRNAs in the urothelium, detrusor, and whole mucosa were greater than the average expression for all receptor subtype mRNAs. 5-HT2B receptor protein was distributed in the apical urothelium and among the detrusor smooth muscle layers. In contrast, the 5-HT7 receptors were within the urothelium middle cell layers and detrusor smooth muscle cells. The expression pattern of each 5-HT receptor subtype mRNA within the BPH urothelium was similar to that in the normal urothelium. The expression level of 5-HT2A receptor mRNA in the BPH group was significantly lower than the normal group; however, the expressions of both 5-HT3A and 5-HT7 mRNAs were significantly higher. The expressions of both 5-HT2B and 5-HT4 mRNAs were not significantly different between the normal and BPH groups. Conclusion: In normal urinary bladders, the expressions of both 5-HT2B and 5-HT7 mRNAs were higher compared to the 5-HT2A, 5-HT3A, and 5-HT4 mRNAs. The distributions of 5-HT2B and 5-HT7 receptors were different in the urothelium and detrusor layers. The 5-HT3A and 5-HT7 receptor mRNAs in the BPH group were significantly higher compared to the normal urothelium, while the 5-HT2A mRNA was significantly lower. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0741-238X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10703556 |
| PubMed |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/26391373 |
|
|
関連名称 |
26391373 |
| 権利 |
|
|
権利情報 |
The final publication is available at link.springer.com |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000411288900004 |
15K10622_03.pdf (1.1 MB)
