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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Expression of 5-Hydroxytryptamine Receptors in Human Urinary Bladders with Benign Prostatic Hyperplasia

http://hdl.handle.net/10091/00021612
f8683b52-3e07-42b6-ac8a-73fccb133947
名前 / ファイル ライセンス アクション
15K10622_03.pdf 15K10622_03.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-09-09
タイトル
言語 en
タイトル Expression of 5-Hydroxytryptamine Receptors in Human Urinary Bladders with Benign Prostatic Hyperplasia
言語
言語 eng
キーワード
主題Scheme Other
主題 5-Hydroxytryptamine receptor
キーワード
主題Scheme Other
主題 Detrusor
キーワード
主題Scheme Other
主題 Human
キーワード
主題Scheme Other
主題 Urinary bladder
キーワード
主題Scheme Other
主題 Urothelium
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 108414

en Imamura, Tetsuya

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 108415

en Ishizuka, Osamu

Search repository
Ogawa, Teruyuki

× Ogawa, Teruyuki

WEKO 108416

en Ogawa, Teruyuki

Search repository
Minagawa, Tomonori

× Minagawa, Tomonori

WEKO 108417

en Minagawa, Tomonori

Search repository
Ishikawa, Masakuni

× Ishikawa, Masakuni

WEKO 108418

en Ishikawa, Masakuni

Search repository
Hiragata, Shiro

× Hiragata, Shiro

WEKO 108419

en Hiragata, Shiro

Search repository
Yokoyama, Hitoshi

× Yokoyama, Hitoshi

WEKO 108420

en Yokoyama, Hitoshi

Search repository
Nakazawa, Masaki

× Nakazawa, Masaki

WEKO 108421

en Nakazawa, Masaki

Search repository
Kurizaki, Yoshiki

× Kurizaki, Yoshiki

WEKO 108422

en Kurizaki, Yoshiki

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 108423

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Ishizuka, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html
信州大学研究者総覧へのリンク
氏名 Ogawa, Teruyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html
信州大学研究者総覧へのリンク
氏名 Minagawa, Tomonori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 SPRINGER
引用
内容記述タイプ Other
内容記述 ADVANCES IN THERAPY.32:S29-S37(2015)
書誌情報 ADVANCES IN THERAPY

巻 32, p. S29-S37, 発行日 2015-09-21
抄録
内容記述タイプ Abstract
内容記述 Introduction: This study investigated the mRNA expression pattern and distribution of 5-hydroxytryptamine (5-HT) receptors 5-HT2A, 5-HT2B, 5-HT3A, 5-HT4, and 5-HT7 within the urothelium and detrusor of normal bladder tissue and in the urothelium of bladders from patients with benign prostatic hyperplasia (BPH). Methods: Normal urinary bladder specimens were obtained from 13 patients undergoing radical cystectomy due to bladder cancer (normal group) and BPH specimens were obtained from 27 benign prostatic obstruction patients receiving transurethral prostatectomy or retropubic prostatectomy. Receptor subtype mRNA expression was determined by real-time reverse transcription polymerase chain reaction on urothelium, detrusor, and whole mucosal preparations. Receptor distribution was determined by immunohistochemistry. Results: In normal tissues, expressions of 5-HT2B and 5-HT7 receptor mRNAs in the urothelium, detrusor, and whole mucosa were greater than the average expression for all receptor subtype mRNAs. 5-HT2B receptor protein was distributed in the apical urothelium and among the detrusor smooth muscle layers. In contrast, the 5-HT7 receptors were within the urothelium middle cell layers and detrusor smooth muscle cells. The expression pattern of each 5-HT receptor subtype mRNA within the BPH urothelium was similar to that in the normal urothelium. The expression level of 5-HT2A receptor mRNA in the BPH group was significantly lower than the normal group; however, the expressions of both 5-HT3A and 5-HT7 mRNAs were significantly higher. The expressions of both 5-HT2B and 5-HT4 mRNAs were not significantly different between the normal and BPH groups. Conclusion: In normal urinary bladders, the expressions of both 5-HT2B and 5-HT7 mRNAs were higher compared to the 5-HT2A, 5-HT3A, and 5-HT4 mRNAs. The distributions of 5-HT2B and 5-HT7 receptors were different in the urothelium and detrusor layers. The 5-HT3A and 5-HT7 receptor mRNAs in the BPH group were significantly higher compared to the normal urothelium, while the 5-HT2A mRNA was significantly lower.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0741-238X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10703556
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/26391373
関連名称
関連名称 26391373
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12325-015-0242-0
関連名称
関連名称 10.1007/s12325-015-0242-0
権利
権利情報 The final publication is available at link.springer.com
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000411288900004
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