Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2019-09-09 |
タイトル |
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タイトル |
Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.abb.2018.04.001 |
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関連名称 |
10.1016/j.abb.2018.04.001 |
キーワード |
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主題 |
Adipocyte, CCAAT-Enhancer-binding proteins, Glucocorticoid receptor, Interleukin-6, Theophylline |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Mitani, Takakazu
Takaya, Tomohide
Harada, Naoki
Katayama, Shigeru
Yamaji, Ryoichi
Nakamura, Soichiro
Ashida, Hitoshi
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信州大学研究者総覧へのリンク |
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氏名 |
Mitani, Takakazu |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Katayama, Shigeru |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFkaPUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Nakamura, Soichiro |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OpyhuNDp.html |
出版者 |
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出版者 |
ELSEVIER SCIENCE INC |
引用 |
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内容記述 |
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.646:98-106(2018) |
書誌情報 |
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
巻 646,
p. 98-106,
発行日 2018-05-15
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抄録 |
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内容記述 |
Adipose tissues in obese individuals are characterized by a state of chronic low-grade inflammation. Pre-adipocytes and adipocytes in this state secrete pro-inflammatory adipokines, such as interleukin 6 (IL-6), which induce insulin resistance and hyperglycemia. Theophylline (1,3-dimethylxanthine) exerts anti-inflammatory effects, but its effects on pro-inflammatory adipokine secretion by pre-adipocytes and adipocytes have not been examined. In this study, we found that theophylline decreased IL-6 secretion by 3T3-L1 pre-adipocytes and mouse-derived primary pre-adipocytes. The synthetic glucocorticoid dexamethasone (DEX) induced IL-6 expression in 3T3-L1 pre-adipocytes, and this effect was suppressed by theophylline at the mRNA level. Knockdown of CCAAT/enhancer binding protein (C/EBP) delta inhibited DEX-induced IL-6 expression, and theophylline suppressed C/EBP delta expression. Furthermore, theophylline suppressed transcriptional activity of the glucocorticoid receptor (GR) through suppression of nuclear localization of GR. In vivo, glucocorticoid corticosterone treatment (100 mu g/mL) increased fasting blood glucose and plasma IL-6 levels in C57BL/6 N mice. Theophylline administration (0.1% diet) reduced corticosterone-increased fasting blood glucose, plasma IL-6 levels, and IL6 gene expression in adipose tissues. These results show that theophylline administration attenuated glucocorticoid-induced hyperglycemia and IL-6 production by inhibiting GR activity. The present findings indicate the potential of theophylline as a candidate therapeutic agent to treat insulin resistance and hyperglycemia. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0003-9861 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00547159 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/29625124/ |
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関連名称 |
29625124 |
権利 |
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権利情報 |
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431838200013 |