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Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein beta degradation by adenosine receptor A1
http://hdl.handle.net/10091/00021615
http://hdl.handle.net/10091/00021615aec5af48-f972-4419-9fe2-aedd77c830e9
| 名前 / ファイル | ライセンス | アクション |
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16K18701_02.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2019-09-09 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein beta degradation by adenosine receptor A1 | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbamcr.2017.09.017 | |||||||||||||||||
| 関連名称 | 10.1016/j.bbamcr.2017.09.017 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Adenosine receptor, Adipogenesis, CCAAT/enhancer-binding protein, Sumoylation, Theobromine | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Mitani, Takakazu
× Mitani, Takakazu
× Watanabe, Shun
× Yoshioka, Yasukiyo
× Katayama, Shigeru
× Nakamura, Soichiro
× Ashida, Hitoshi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Mitani, Takakazu | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Katayama, Shigeru | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFkaPUkh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Nakamura, Soichiro | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpyhuNDp.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | ELSEVIER SCIENCE BV | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.1864(12):2438-2448(2017) | |||||||||||||||||
| 書誌情報 |
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 巻 1864, 号 12, p. 2438-2448, 発行日 2017-12 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Theobromine, a methylxanthine derived from cacao beans, reportedly has various health-promoting properties but molecular mechanism by which effects of theobromine on adipocyte differentiation and adipogenesis remains unclear. In this study, we aimed to clarify the molecular mechanisms of the anti-adipogenic effect of theobromine in vitro and in vivo. ICR mice (4 week-old) were administered with theobromine (0.1 g/kg) for 7 days. Theobromine administration attenuated gains in body and epididymal adipose tissue weights in mice and suppressed expression of adipogenic-associated genes in mouse adipose tissue. In 3T3-L1 preadipocytes, theobromine caused degradation of C/EBP beta protein by the ubiquitin-proteasome pathway. Pull down assay showed that theobromine selectively interacts with adenosine receptor A1(AR1), and AR1 knockdown inhibited theobromine-induced C/ESPfi degradation. Theobromine increased sumoylation of C/EBP beta' at Lys133. Expression of the small ubiquitin-like modifier (SUMO)-specific protease 2 (SENP2) gene, coding for a desumoylation enzyme, was suppressed by theobromine. In vivo knockdown studies showed that AR1 knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPP degradation by increasing its sumoylation. Furthermore, the inhibition of AR1 signaling is important for theobromine-induced C/EBP beta degradation. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0167-4889 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA1050609X | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/28965824/ | |||||||||||||||||
| 関連名称 | 28965824 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| WoS | ||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000416195800019 | |||||||||||||||||
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Cite as
Mitani, Takakazu, Watanabe, Shun, Yoshioka, Yasukiyo, Katayama, Shigeru, Nakamura, Soichiro, Ashida, Hitoshi, 2017, Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein beta degradation by adenosine receptor A1: ELSEVIER SCIENCE BV, 2438–2448 p.
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