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Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force
http://hdl.handle.net/10091/00021965
http://hdl.handle.net/10091/000219652e90600b-0311-4c10-b0e3-13f8486ef3bb
| 名前 / ファイル | ライセンス | アクション |
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26410232_04.pdf (3.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2020-03-11 | |||||||||||||||||||
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| タイトル | Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1021/acs.langmuir.6b03470 | |||||||||||||||||||
| 関連名称 | 10.1021/acs.langmuir.6b03470 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||
| 著者 |
Kanayama, Naoki
× Kanayama, Naoki
× Sekine, Taito
× Ozasa, Kazunari
× Kishi, Satomi
× Nyu, Takashi
× Hayashi, Tomohiro
× Maeda, Mizuo
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Kanayama, Naoki | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gFAUbUkh.html | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | AMER CHEMICAL SOC | |||||||||||||||||||
| 引用 | ||||||||||||||||||||
| 内容記述 | LANGMUIR.32(49):13296-13304(2016) | |||||||||||||||||||
| 書誌情報 |
LANGMUIR 巻 32, 号 49, p. 13296-13304, 発行日 2016-11-07 |
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| 抄録 | ||||||||||||||||||||
| 内容記述 | Double-stranded DNA-grafted nanoparticles (dsDNA-NPs) exhibit a unique dispersion behavior under high-salt conditions depending on the pairing status of their outermost base pairs (pairing or unpairing). The dsDNA-NPs having complementary (i.e., pairing) outermost base pairs spontaneously aggregate under high-salt conditions, but not when their outermost base pairs are mismatched (unpairing). In this study, we used colloidal probe atomic force microscopy to examine how the outermost base pairs affect the interaction between the dsDNA-grafted layers (dsDNA layers). To precisely assess the subtle structural differences in the dsDNA layers, we developed a method for the formation of a homogenous dsDNA layer on gold surfaces using hairpin shaped DNAs. Homogenous dsDNA layers having complementary (G-C) or mismatched (C-C) outermost base pairs were grafted onto the surfaces of colloidal probes and gold substrates. Force distance curves measured in an aqueous medium under high-salt conditions revealed that the surface forces between the dsDNA layers were bilateral in nature and were governed by the outermost base pairs. Between complementary outermost dsDNA layers, the surface force changed from repulsive to attractive with an increase in the NaCl concentration (10-1000 mM). The attraction observed under high-salt conditions was attributed to the site-specific interaction proceeded only between complementary dsDNA terminals, the so-called blunt-end stacking. In fact, between mismatched outermost dsDNA layers, the repulsive force was mostly dominant within the same NaCl concentration range. Our results clearly revealed that the pairing status of the outermost base pairs has significant implications for the surface forces between dsDNA layers, leading to the unique dispersion behavior of dsDNA-NPs. | |||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0743-7463 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA10461730 | |||||||||||||||||||
| PubMed | ||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/27951695 | |||||||||||||||||||
| 関連名称 | 27951695 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html), which permits copying and redistribution of the article or any adaptations for non-commercial purposes. | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000389866300038 | |||||||||||||||||||
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Kanayama, Naoki, Sekine, Taito, Ozasa, Kazunari, Kishi, Satomi, Nyu, Takashi, Hayashi, Tomohiro, Maeda, Mizuo, 2016, Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force: AMER CHEMICAL SOC, 13296–13304 p.
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