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A somatic mutation in signal transducer and activator transcription 3 (STAT3) has been reported in patients with CLPD-NK; however, the details of the mutational profiles and their clinical significance remain unclear. We performed mutation analyses of the STAT3, STAT5B, and TNF-alpha-induced protein 3 (TNFAIP3) genes for mononuclear cell-derived DNA in 17 CLPD-NK patients using allele-specific polymerase chain reaction and amplicon sequencing. Mutations in STAT3 and TNFAIP3 were found in 29% (5/17) and 6% (1/17) of cases, respectively. All patients were negative for STAT5B mutations. In all three STAT3-mutation (+) patients studied, STAT3 mutations were restricted to sorted NK cells. STAT3 mutation (+) patients had a lower hemoglobin level (6.6g/dL vs. 13.9g/dL, P=0.0044) and showed a trend toward reduced neutrophil counts (1.22x10(9)/L vs. 3.10x10(9)/L, P=0.070) compared with the STAT3 mutation (-) patients. No mutations in these genes were found in patients with neuropathy. These results suggest that heterogeneity of CLPD-NK and STAT3-mutated NK cells may play a significant role in cytopenia in CLPD-NK patients."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5ddd\u4e0a, \u5fb9"}], "nameIdentifiers": [{"nameIdentifier": "109515", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15MH012C_yoshi.pdf", "filesize": [{"value": "174.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 174500.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/21388/files/15MH012C_yoshi.pdf"}, "version_id": "4dccc57d-fb00-4633-bd96-6adcba2a9d71"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "15MH012C_shinsa.pdf", "filesize": [{"value": "119.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 119500.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/21388/files/15MH012C_shinsa.pdf"}, "version_id": "ad35a9d3-24bb-42f3-b987-74a59bd91fa1"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "15MH012C_ronbun.pdf", "filesize": [{"value": "189.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 Japanese Society of Hematology 2019 / The original publication is available at www.springerlink.com", "licensetype": "license_note", "mimetype": "application/pdf", "size": 189300.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/21388/files/15MH012C_ronbun.pdf"}, "version_id": "aac9f76b-f6b2-4250-bde5-a7155c9c4700"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells \uff08NK\u7d30\u80de\u306b\u304a\u3051\u308bSTAT3\u5909\u7570\u306fNK\u7d30\u80de\u6162\u6027\u30ea\u30f3\u30d1\u5897\u6b96\u7570\u5e38\u75c7\u60a3\u8005\u306e\u8840\u7403\u6e1b\u5c11\u3068\u95a2\u9023\u3059\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells \uff08NK\u7d30\u80de\u306b\u304a\u3051\u308bSTAT3\u5909\u7570\u306fNK\u7d30\u80de\u6162\u6027\u30ea\u30f3\u30d1\u5897\u6b96\u7570\u5e38\u75c7\u60a3\u8005\u306e\u8840\u7403\u6e1b\u5c11\u3068\u95a2\u9023\u3059\u308b\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00022145", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-06-15"}, "publish_date": "2020-06-15", "publish_status": "0", "recid": "21388", "relation": {}, "relation_version_is_last": true, "title": ["STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells \uff08NK\u7d30\u80de\u306b\u304a\u3051\u308bSTAT3\u5909\u7570\u306fNK\u7d30\u80de\u6162\u6027\u30ea\u30f3\u30d1\u5897\u6b96\u7570\u5e38\u75c7\u60a3\u8005\u306e\u8840\u7403\u6e1b\u5c11\u3068\u95a2\u9023\u3059\u308b\uff09"], "weko_shared_id": -1}
STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells (NK細胞におけるSTAT3変異はNK細胞慢性リンパ増殖異常症患者の血球減少と関連する)
http://hdl.handle.net/10091/00022145
1f80c0eb-3559-436d-91a4-473a69ea3f5e
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-06-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells (NK細胞におけるSTAT3変異はNK細胞慢性リンパ増殖異常症患者の血球減少と関連する) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
著者 |
川上, 徹
× 川上, 徹 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 川上 徹. STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells (NK細胞におけるSTAT3変異はNK細胞慢性リンパ増殖異常症患者の血球減少と関連する). 信州大学, 2019, 博士論文. | |||||
書誌情報 |
発行日 2019-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1178号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
Doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1178号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。INTERNATIONAL JOURNAL OF HEMATOLOGY. 109(5):563-571 (2019); doi:10.1007/s12185-019-02625-x. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=30859397 | |||||
関連名称 | ||||||
関連名称 | 30859397 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s12185-019-02625-x | |||||
関連名称 | ||||||
関連名称 | 10.1007/s12185-019-02625-x | |||||
権利 | ||||||
権利情報 | © Japanese Society of Hematology 2019 / The original publication is available at www.springerlink.com | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000468508100006 |