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Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. Int J Rheum Dis. 2019; 22: 1489\u20131497, which has been published in final form at https://doi.org/10.1111/1756-185X.13610. 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We aimed to establish more specific diagnostic criteria for PFAPA based on the clinical characteristics of PFAPA patients in our directory. Method The clinical, laboratory, genetic, and family history details of 257 Japanese PFAPA patients treated at our and other affiliated hospitals between April 2000 and April 2018 were analyzed along with quantitative measurements of the number of CD64 molecules on neutrophils, and the levels of serum inflammatory cytokines. The sensitivity and specificity of the criteria were calculated for several diseases. Results Because recurrent fevers were crucial findings, they were defined as the required criterion. Tonsillitis/pharyngitis with white moss were important accompanying signs. Other symptoms associated with febrile episodes were cervical lymphadenitis with tenderness, aphthous stomatitis, sore throat, vomiting, and headache but not cough. A total of 159 (62%) patients had a family history of recurrent fevers, indicating autosomal dominant inheritance. C-reactive protein levels were extremely elevated during febrile attacks but normal in attack-free periods. Serum immunoglobulin D levels were high in 72 of the 199 tested patients. Oral glucocorticoid and cimetidine were extremely effective in all and 51.6% of the patients, respectively. We defined the above as supportive criteria. These criteria were sensitive and specific enough to distinguish PFAPA from other recurrent fever diseases. Raised serum interferon-gamma levels and remarkable CD64 expression on neutrophils during flare-ups were recognized, indicating they contributed to diagnosis. 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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA). (周期性発熱・アフタ性口内炎・咽頭炎・頸部リンパ節炎症候群(PFAPA)の臨床学的特徴と新診断基準)

http://hdl.handle.net/10091/00022156
3669d692-f51f-4426-a49a-54f827512cbe
名前 / ファイル ライセンス アクション
15MH025E_yoshi.pdf 内容の要旨 (182.9 kB)
15MH025E_shinsa.pdf 審査結果の要旨 (124.2 kB)
15MH025E_ronbun.pdf 博士論文の全文 (257.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-06-15
タイトル
言語 en
タイトル Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA). (周期性発熱・アフタ性口内炎・咽頭炎・頸部リンパ節炎症候群(PFAPA)の臨床学的特徴と新診断基準)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 竹内, 勇介

× 竹内, 勇介

WEKO 109526

竹内, 勇介

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出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 竹内 勇介. Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA). (周期性発熱・アフタ性口内炎・咽頭炎・頸部リンパ節炎症候群(PFAPA)の臨床学的特徴と新診断基準). 信州大学, 2019, 博士論文.
書誌情報
発行日 2019-03-31
学位授与番号
学位授与番号 13601甲第1189号
学位授与年月日
学位授与年月日 2019-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1189号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 22(8):1489-1497 (2019); doi:10.1111/1756-185X.13610.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=31131563
関連名称
関連名称 31131563
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/1756-185X.13610
関連名称
関連名称 10.1111/1756-185X.13610
権利
権利情報 This is the peer reviewed version of the following article: Takeuchi, Y, Shigemura, T, Kobayashi, N, et al. Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. Int J Rheum Dis. 2019; 22: 1489–1497, which has been published in final form at https://doi.org/10.1111/1756-185X.13610. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000478745100018
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