ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "2480cd3a-4634-4e98-9e7e-692b453e8ec7"}, "_deposit": {"id": "21404", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21404"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00021404", "sets": []}, "author_link": ["109531"], "item_14_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-03-31", "bibliographicIssueDateType": "Issued"}}]}, "item_14_date_granted_8": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2020-03-31"}]}, "item_14_degree_grantor_10": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u4fe1\u5dde\u5927\u5b66(Shinshu university)"}]}]}, "item_14_degree_name_9": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_14_description_26": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u96d1\u8a8c\u306b\u767a\u8868\u3002AMERICAN JOURNAL OF PATHOLOGY. 189(12):2487-2502 (2019); doi:10.1016/j.ajpath.2019.08.011.", "subitem_description_type": "Other"}]}, "item_14_description_37": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Thesis", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "\u677e\u4e95\u3000\u5468\u5e73. Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation \uff08\u5185\u56e0\u6027\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9\u6b20\u4e4f\u306f\u3001\u30ea\u30f3\u30d1\u7ba1\u5f62\u6210\u3068M2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8853\u5f8c\u30ea\u30f3\u30d1\u6d6e\u816b\u3092\u60aa\u5316\u3055\u305b\u308b\uff09. \u4fe1\u5dde\u5927\u5b66, 2020, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1194\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000501397900012"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "31541644"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=31541644", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.ajpath.2019.08.011"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.ajpath.2019.08.011", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1194\u53f7"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "MICE LACKING; LYMPHANGIOGENESIS; CGRP; ANGIOGENESIS; RECEPTOR; FLOW; ABNORMALITIES; NEUROPEPTIDE; ANASTOMOSIS; RESISTANCE"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Lymphedema is a chronic condition caused by disruption of lymphatic vessels, which often occurs after invasive surgery. Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide produced by alternative splicing of the primary transcript of the calcitonin/CGRP gene (Caka). CGRP was initially identified as a neuropeptide released primarily from sensory nerves and involved in regulating pathophysiological nociceptive pain. However, recent studies have shown CGRP is also released from a variety of other cells and possesses multiple functions. In this study, CGRP knockout (-/-) mice were used to show the actions of endogenous CGRP in postoperative lymphedema. After generating a mouse postoperative tail lymphedema model, the edema was observed to be more severe in CGRP (-/-) mice than in wild-type mice. Numbers of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1)-positive lymphatic capillaries were decreased and lymphatic capillary formation-related factors were down-regulated in CGRP(-/-) mice. In addition, accumulation of M2 but not M1 macrophages was selectively reduced in the edematous tissue of CGRP(-/-) mice. Selective depletion of M2 macrophages decreased lymphatic capillary formation and worsened lymphedema in wild-type mice but not CGRP(-/-) mice, where numbers of M2 macrophages were already diminished. These findings suggest that endogenous CGRP acts to ameliorate postoperative lymphedema by enhancing Lymphatic capillary formation and that M2 macrophages play critical roles. CGRP may be a useful therapeutic target for the treatment of postoperative lymphedema."}]}, "item_1627890986942": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u677e\u4e95, \u5468\u5e73"}], "nameIdentifiers": [{"nameIdentifier": "109531", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "16MH022D_yoshi.pdf", "filesize": [{"value": "195.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 195800.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/21404/files/16MH022D_yoshi.pdf"}, "version_id": "30ae5c4f-d77b-4b40-957b-58dd6f241c09"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "16MH022D_shinsa.pdf", "filesize": [{"value": "146.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 146700.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/21404/files/16MH022D_shinsa.pdf"}, "version_id": "bc5188c3-d5eb-433a-9e44-20a09fd21aec"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-09-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "16MH022D_ronbun.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "\u00a9 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "licensetype": "license_note", "mimetype": "application/pdf", "size": 2600000.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/21404/files/16MH022D_ronbun.pdf"}, "version_id": "b1ad231b-2b10-4faa-861a-9b2e68cce08d"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation \uff08\u5185\u56e0\u6027\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9\u6b20\u4e4f\u306f\u3001\u30ea\u30f3\u30d1\u7ba1\u5f62\u6210\u3068M2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8853\u5f8c\u30ea\u30f3\u30d1\u6d6e\u816b\u3092\u60aa\u5316\u3055\u305b\u308b\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation \uff08\u5185\u56e0\u6027\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9\u6b20\u4e4f\u306f\u3001\u30ea\u30f3\u30d1\u7ba1\u5f62\u6210\u3068M2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8853\u5f8c\u30ea\u30f3\u30d1\u6d6e\u816b\u3092\u60aa\u5316\u3055\u305b\u308b\uff09", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00022161", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-06-15"}, "publish_date": "2020-06-15", "publish_status": "0", "recid": "21404", "relation": {}, "relation_version_is_last": true, "title": ["Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation \uff08\u5185\u56e0\u6027\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9\u6b20\u4e4f\u306f\u3001\u30ea\u30f3\u30d1\u7ba1\u5f62\u6210\u3068M2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u96c6\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8853\u5f8c\u30ea\u30f3\u30d1\u6d6e\u816b\u3092\u60aa\u5316\u3055\u305b\u308b\uff09"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation (内因性カルシトニン遺伝子関連ペプチド欠乏は、リンパ管形成とM2マクロファージ集積を抑制することで、術後リンパ浮腫を悪化させる)

http://hdl.handle.net/10091/00022161
c953e9fa-470d-4185-be4e-907836225ed9
名前 / ファイル ライセンス アクション
16MH022D_yoshi.pdf 内容の要旨 (195.8 kB)
16MH022D_shinsa.pdf 審査結果の要旨 (146.7 kB)
16MH022D_ronbun.pdf 博士論文の全文 (2.6 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-06-15
タイトル
言語 en
タイトル Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation (内因性カルシトニン遺伝子関連ペプチド欠乏は、リンパ管形成とM2マクロファージ集積を抑制することで、術後リンパ浮腫を悪化させる)
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
著者 松井, 周平

× 松井, 周平

WEKO 109531

松井, 周平

Search repository
出版者
出版者 信州大学
引用
内容記述タイプ Other
内容記述 松井 周平. Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation (内因性カルシトニン遺伝子関連ペプチド欠乏は、リンパ管形成とM2マクロファージ集積を抑制することで、術後リンパ浮腫を悪化させる). 信州大学, 2020, 博士論文.
書誌情報
発行日 2020-03-31
学位授与番号
学位授与番号 13601甲第1194号
学位授与年月日
学位授与年月日 2020-03-31
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 信州大学(Shinshu university)
学位の区分
Doctoral
学位の分野
医学
学位の報告番号
甲第1194号
内容記述
内容記述タイプ Other
内容記述 雑誌に発表。AMERICAN JOURNAL OF PATHOLOGY. 189(12):2487-2502 (2019); doi:10.1016/j.ajpath.2019.08.011.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Thesis
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=31541644
関連名称
関連名称 31541644
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ajpath.2019.08.011
関連名称
関連名称 10.1016/j.ajpath.2019.08.011
権利
権利情報 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
WoS
Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000501397900012
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 07:30:05.356723
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio