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The neurotrophic factor artemin (Artn) is highly expressed in the epidermis of AhR-CA mice and causes hypersensitivity to itch (alloknesis) by elongating nerves into the epidermis. However, whether the Artn gene is regulated directly by AhR or indirectly through complex regulation associated with AhR remains unclear. To this end, we previously conducted chromatin immunoprecipitation-sequencing analyses of the Ann locus and found a xenobiotic response element (XRE) motif located far upstream (52 kb) of the gene. Therefore, in this study, we addressed whether the XRE actually regulates the Artn gene expression by deleting the region containing the motif. We generated two lines of Artn(Delta)(XRE) mice. In the mouse epidermis, inducible expression of the Artn gene by the AhR agonist 3-methylcholanthrene was substantially suppressed compared to that in wild-type mice. Importantly, in AhR-CA::Artn (Delta)(XRE )mice, Artn expression was significantly suppressed, and alloknesis was improved. These results demonstrate that the Artn gene is indeed regulated by the distal XRE-containing enhancer, and alloknesis in AhR-CA mice is provoked by the AhR-mediated direct induction of the Artn gene."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "枝光, 智大", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "109537", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "16MH005D_yoshi.pdf", "filesize": [{"value": "134.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 134500.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/21410/files/16MH005D_yoshi.pdf"}, "version_id": "8000cac1-d0dd-4ddf-ba5e-effc1ff6f04b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "16MH005D_shinsa.pdf", "filesize": [{"value": "111.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 111500.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/21410/files/16MH005D_shinsa.pdf"}, "version_id": "b93d66ac-529f-492a-9ef8-d6674f7d491c"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "16MH005D_ronbun.pdf", "filesize": [{"value": "3.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 American Society for Microbiology", "licensetype": "license_note", "mimetype": "application/pdf", "size": 3800000.0, "url": {"label": "博士論文の全文", "objectType": "fulltext", "url": "https://soar-ir.repo.nii.ac.jp/record/21410/files/16MH005D_ronbun.pdf"}, "version_id": "a247380f-79ff-460c-a1c8-3f731eae22c1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する)", "subitem_title_language": "en"}]}, "item_type_id": "14", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/00022167", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-06-15"}, "publish_date": "2020-06-15", "publish_status": "0", "recid": "21410", "relation": {}, "relation_version_is_last": true, "title": ["Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する)"], "weko_shared_id": -1}
Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する)
http://hdl.handle.net/10091/00022167
http://hdl.handle.net/10091/00022167fd1458b7-4be4-4491-8d9d-dd4f70edb5e6
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内容の要旨 (134.5 kB)
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審査結果の要旨 (111.5 kB)
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博士論文の全文 (3.8 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-06-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
枝光, 智大
× 枝光, 智大 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 枝光 智大. Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression (芳香族炭化水素受容体は神経栄養因子アルテミン遺伝子を直接制御する). 信州大学, 2020, 博士論文. | |||||
書誌情報 |
発行日 2020-03-31 |
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学位授与番号 | ||||||
学位授与番号 | 13601甲第1200号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-31 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
甲第1200号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。MOLECULAR AND CELLULAR BIOLOGY. 39(20):e00190-19 (2019); doi:10.1128/MCB.00190-19. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/31358547/ | |||||
関連名称 | 31358547 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1128/MCB.00190-19 | |||||
関連名称 | 10.1128/MCB.00190-19 | |||||
権利 | ||||||
権利情報 | © 2019 American Society for Microbiology | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000488194300001 |