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Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once-daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation (造血幹細胞移植におけるアゾール系抗真菌薬の違いがタクロリムスの注射製剤から経口徐放性製剤変更時の血中濃度の変動に及ぼす影響). 信州大学, 2019, 博士論文.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601乙第1234号"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000475405400008"}]}, "item_14_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州大学"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "30950099"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/30950099/", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/jcpt.12834"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/jcpt.12834", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: Mimura, A, Yamaori, S, Ikemura, N, Katsuyama, Y, Matsuzawa, N, Ohmori, S. Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once‐daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation. J Clin Pharm Ther. 2019; 44: 565–571, which has been published in final form at https://doi.org/10.1111/jcpt.12834. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]}, "item_14_select_71": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_text_value": "doctoral"}]}, "item_14_text_12": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_text_value": "医学"}]}, "item_14_text_13": {"attribute_name": "学位の報告番号", "attribute_value_mlt": [{"subitem_text_value": "乙第1234号"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "administration route; azole antifungal drugs; drug interaction; fluconazole; hematopoietic stem cell transplantation; tacrolimus; voriconazole"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "TWICE-DAILY TACROLIMUS; VERSUS-HOST-DISEASE; CALCINEURIN INHIBITORS; COMPARING METHOTREXATE; HUMAN LIVER; CYP3A5; IMPACT; PHARMACOKINETICS; CYP3A5-ASTERISK-3; CYCLOSPORINE"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "What is known and objective Azole antifungal drugs are often co-administered with tacrolimus after allogeneic hematopoietic stem cell transplantation (HSCT). However, the influence of azole antifungal drugs on variation in tacrolimus pharmacokinetics when switching from intravenous tacrolimus (Tac-iv) to once-daily modified release tacrolimus (Tac-MR) remains to be elucidated. This study was performed to evaluate the effects of oral azole antifungal drugs on variation in tacrolimus pharmacokinetics after conversion to Tac-MR in HSCT patients. Methods Patients concomitantly receiving fluconazole (FLCZ) or voriconazole (VRCZ) along with tacrolimus were evaluated retrospectively. Blood tacrolimus concentrations before and after changing to oral administration were compared between FLCZ and VRCZ groups. Results and discussion A total of 52 patients (34 FLCZ and 18 VRCZ) were included in the analysis. There were no significant differences in the most recent daily dose (D-iv) and blood level (C-iv) of Tac-iv, C-iv/D-iv, and ratio of daily dose of tacrolimus on the first to second day after changing to Tac-MR (Dpo1-2) to D-iv between FLCZ and VRCZ groups (P \u003e 0.2). The trough levels of tacrolimus on the first to second day after switching to Tac-MR (Cpo1-2) and on the third to fifth day after the switch (Cpo3-5) were significantly higher in the VRCZ group than the FLCZ group (P \u003c 0.05). The values of (C-iv/D-iv)/(Cpo1-2/Dpo1-2) and (C-iv/D-iv)/(Cpo3-5/Dpo3-5) in the VRCZ group were significantly lower compared with those in the FLCZ group (P \u003c 0.05). Furthermore, individual values of (C-iv/D-iv)/(Cpo3-5/Dpo3-5) in the FLCZ group varied widely. What is new and conclusion Voriconazole increased blood tacrolimus level more markedly than FLCZ after switching to Tac-MR, whereas FLCZ caused a large variation in tacrolimus blood level. These results suggest that therapeutic monitoring of tacrolimus after the switch may need to be performed carefully considering that orally co-administered VRCZ and FLCZ exhibit different change in blood tacrolimus level just after the switch."}]}, "item_1627890986942": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_be7fb7dd8ff6fe43", "subitem_version_type": "NA"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "三村, 享", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "109554", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "18MR0018_yoshi.pdf", "filesize": [{"value": "185.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 185700.0, "url": {"label": "内容の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/21427/files/18MR0018_yoshi.pdf"}, "version_id": "1f54fb61-1cf5-4c4c-93c7-e9ca7932b662"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "18MR0018_shinsa.pdf", "filesize": [{"value": "184.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 184300.0, "url": {"label": "審査結果の要旨", "url": "https://soar-ir.repo.nii.ac.jp/record/21427/files/18MR0018_shinsa.pdf"}, "version_id": "c34bac90-69d7-444c-a17a-b6464d811896"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "18MR0018_ronbun.pdf", "filesize": [{"value": "673.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is the peer reviewed version of the following article: Mimura, A, Yamaori, S, Ikemura, N, Katsuyama, Y, Matsuzawa, N, Ohmori, S. 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Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once-daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation (造血幹細胞移植におけるアゾール系抗真菌薬の違いがタクロリムスの注射製剤から経口徐放性製剤変更時の血中濃度の変動に及ぼす影響)
http://hdl.handle.net/10091/00022184
http://hdl.handle.net/10091/00022184d6f66f0d-26e7-4520-af03-eca5d4f7b630
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審査結果の要旨 (184.3 kB)
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博士論文の全文 (673.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-06-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once-daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation (造血幹細胞移植におけるアゾール系抗真菌薬の違いがタクロリムスの注射製剤から経口徐放性製剤変更時の血中濃度の変動に及ぼす影響) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
三村, 享
× 三村, 享 |
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出版者 | ||||||
出版者 | 信州大学 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 三村 享. Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once-daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation (造血幹細胞移植におけるアゾール系抗真菌薬の違いがタクロリムスの注射製剤から経口徐放性製剤変更時の血中濃度の変動に及ぼす影響). 信州大学, 2019, 博士論文. | |||||
書誌情報 |
発行日 2019-06-26 |
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学位授与番号 | ||||||
学位授与番号 | 13601乙第1234号 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-06-26 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13601 | |||||
学位授与機関名 | 信州大学(Shinshu university) | |||||
学位の区分 | ||||||
doctoral | ||||||
学位の分野 | ||||||
医学 | ||||||
学位の報告番号 | ||||||
乙第1234号 | ||||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 雑誌に発表。JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. 44(4):565-571 (2019); doi:10.1111/jcpt.12834. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Thesis | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/30950099/ | |||||
関連名称 | 30950099 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/jcpt.12834 | |||||
関連名称 | 10.1111/jcpt.12834 | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Mimura, A, Yamaori, S, Ikemura, N, Katsuyama, Y, Matsuzawa, N, Ohmori, S. Influence of azole antifungal drugs on blood tacrolimus levels after switching from intravenous tacrolimus to once‐daily modified release tacrolimus in patients receiving allogeneic hematopoietic stem cell transplantation. J Clin Pharm Ther. 2019; 44: 565–571, which has been published in final form at https://doi.org/10.1111/jcpt.12834. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
出版タイプ | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
WoS | ||||||
Web of Science | ||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000475405400008 |