Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-02-04 |
タイトル |
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タイトル |
Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2016.03.060 |
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関連名称 |
10.1016/j.bbrc.2016.03.060 |
キーワード |
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主題 |
Atherosclerosis, Cholesterol, Cyclic phosphatidic acid, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C) |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Tsukahara, Tamotsu
Haniu, Hisao
Matsuda, Yoshikazu
Murakmi-Murofushi, Kimiko
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信州大学研究者総覧へのリンク |
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氏名 |
Haniu, Hisao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
出版者 |
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出版者 |
ACADEMIC PRESS INC ELSEVIER SCIENCE |
引用 |
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内容記述 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 473(1):107-113 (2016) |
書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
巻 473,
号 1,
p. 107-113,
発行日 2016-04-22
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抄録 |
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内容記述 |
Plasma cholesterol levels are associated with an increased risk of developing atherosclerosis. An elevated low-density lipoprotein cholesterol (LDL-C) level is a hallmark of hypercholesterolemia in metabolic syndrome. Our previous study suggested that when acetylated LDL (AC-LDL) was co-applied with a PPARy agonist, rosiglitazone (ROSI), many oil red O-positive macrophages could be observed. However, addition of cyclic phosphatidic acid (CPA) to ROSI-stimulated macrophages completely abolished oil red O-stained cells, indicating that cPA inhibits PPARy-regulated AC-LDL uptake. This study aimed to determine whether metabolically stabilized cPA, in the form of a carba-derivative of CPA (2ccPA), could reduce plasma cholesterol levels and affect the expression of genes related to atherosclerosis in apolipoprotein E-knockout (apoE-1-) mice. 2ccPA reduced LDL-C levels in these mice (n = 3) from 460 to 330 mg/ml, from 420 to 350 mg/ml, and 420 to 281 mg/m1 under a western-type diet. 2ccPA also reduced expression of lipid metabolism-related genes, cytokines, and chemokines in ApoE-deficient mice on a high-fat diet. Taken together, these results suggest that 2ccPA governs anti-atherogenic activities in the carotid arteries of apoE-deficient mice. (C) 2016 Elsevier Inc. All rights reserved. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0006-291X |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00564395 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/27012212 |
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関連名称 |
27012212 |
権利 |
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権利情報 |
©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000374800700017 |