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Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice
http://hdl.handle.net/10091/00022477
http://hdl.handle.net/10091/000224770912899b-34ce-44d6-873e-1d03d67697a8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBRC-473-107.pdf (469.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-02-04 | |||||
| タイトル | ||||||
| タイトル | Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2016.03.060 | |||||
| 関連名称 | 10.1016/j.bbrc.2016.03.060 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Atherosclerosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cholesterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cyclic phosphatidic acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | High-density lipoprotein cholesterol (HDL-C) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Low-density lipoprotein cholesterol (LDL-C) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Haniu, Hisao× Matsuda, Yoshikazu× Murakmi-Murofushi, Kimiko |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Haniu, Hisao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
| 出版者 | ||||||
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 473(1):107-113 (2016) | |||||
| 書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 巻 473, 号 1, p. 107-113, 発行日 2016-04-22 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Plasma cholesterol levels are associated with an increased risk of developing atherosclerosis. An elevated low-density lipoprotein cholesterol (LDL-C) level is a hallmark of hypercholesterolemia in metabolic syndrome. Our previous study suggested that when acetylated LDL (AC-LDL) was co-applied with a PPARy agonist, rosiglitazone (ROSI), many oil red O-positive macrophages could be observed. However, addition of cyclic phosphatidic acid (CPA) to ROSI-stimulated macrophages completely abolished oil red O-stained cells, indicating that cPA inhibits PPARy-regulated AC-LDL uptake. This study aimed to determine whether metabolically stabilized cPA, in the form of a carba-derivative of CPA (2ccPA), could reduce plasma cholesterol levels and affect the expression of genes related to atherosclerosis in apolipoprotein E-knockout (apoE-1-) mice. 2ccPA reduced LDL-C levels in these mice (n = 3) from 460 to 330 mg/ml, from 420 to 350 mg/ml, and 420 to 281 mg/m1 under a western-type diet. 2ccPA also reduced expression of lipid metabolism-related genes, cytokines, and chemokines in ApoE-deficient mice on a high-fat diet. Taken together, these results suggest that 2ccPA governs anti-atherogenic activities in the carotid arteries of apoE-deficient mice. (C) 2016 Elsevier Inc. All rights reserved. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00564395 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/27012212 | |||||
| 関連名称 | 27012212 | |||||
| 権利 | ||||||
| 権利情報 | ©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000374800700017 | |||||
