WEKO3
アイテム
Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration
http://hdl.handle.net/10091/00022478
http://hdl.handle.net/10091/000224787c6c2b9b-dce9-42ec-b91c-31eb2e7e4d5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
materials-10-00033.pdf (14.1 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-04 | |||||
| タイトル | ||||||
| タイトル | Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 関連識別子 | https://doi.org/10.3390/ma10010033 | |||||
| 関連名称 | 10.3390/ma10010033 | |||||
| キーワード | ||||||
| 主題 | regenerative medicine, scaffold, unidirectional pore | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tanaka, Manabu
× Tanaka, Manabu× Haniu, Hisao× Kamanaka, Takayuki× Takizawa, Takashi× Sobajima, Atsushi× Yoshida, Kazushige× Aoki, Kaoru× Okamoto, Masanori× Kato, Hiroyuki× Saito, Naoto |
|||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Haniu, Hisao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Takizawa, Takashi | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Yoshida, Kazushige | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Aoki, Kaoru | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Okamoto, Masanori | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kato, Hiroyuki | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Saito, Naoto | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html | |||||
| 出版者 | ||||||
| 出版者 | MDPI AG | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | MATERIALS. 10(1):33 (2017) | |||||
| 書誌情報 |
MATERIALS 巻 10, 号 1, p. 33, 発行日 2017-01 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The unidirectional porous hydroxyapatite HAp (UDPHAp) is a scaffold with continuous communicated pore structure in the axial direction. We evaluated and compared the ability of the UDPHAp as a three-dimensional (3D) bone tissue engineering scaffold to the interconnected calcium porous HAp ceramic (IP-CHA). To achieve this, we evaluated in vitro the compressive strength, controlled rhBMP-2 release behavior, adherent cell morphology, cell adhesion manner, and cell attachment of UDPHAp. As a further in vivo experiment, UDPHAp and IP-CHA with rhBMP-2 were transplanted into mouse calvarial defects to evaluate their bone-forming ability. The Results demonstrated that the maximum compressive strengths of the UDPHAp was 7.89 +/- 1.23 MPa and higher than that of IP-CHA (1.92 +/- 0.53 MPa) (p = 0.0039). However, the breaking energies were similar (8.99 +/- 2.72 vs. 13.95 +/- 5.69 mJ, p = 0.055). The UDPHAp released rhBMP-2 more gradually in vivo. Cells on the UDPHAp adhered tightly to the surface, which had grown deeply into the scaffolds. A significant increase in cell number on the UDPHAp was observed compared to the IP-CHA on day 8 (102,479 +/- 34,391 vs. 32,372 +/- 29,061 estimated cells per scaffold, p = 0.0495). In a mouse calvarial defect model, the percentages of new bone area (mature bone + trabecular bone) in the 2x field were 2.514% +/- 1.224% for the IP-CHA group and 7.045% +/- 2.055% for the UDPHAp group, and the percentage was significantly higher in the UDPHAp group (p = 0.0209). While maintaining the same strength as the IP-CHA, the UDPHAp with 84% porosity showed a high cell number, high cell invasiveness, and excellent bone formation. We believe the UDPHAp is an excellent material that can be applied to bone regenerative medicine. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1996-1944 | |||||
| 書誌レコードID | ||||||
| 識別子タイプ | NCID | |||||
| 関連識別子 | BB25053562 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/28772390 | |||||
| 関連名称 | 28772390 | |||||
| 権利 | ||||||
| 権利情報 | © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394838800033 | |||||
