| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-02-04 |
| タイトル |
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|
タイトル |
Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration |
| 言語 |
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|
言語 |
eng |
| DOI |
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|
関連識別子 |
https://doi.org/10.3390/ma10010033 |
|
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関連名称 |
10.3390/ma10010033 |
| キーワード |
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主題 |
regenerative medicine, scaffold, unidirectional pore |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Tanaka, Manabu
Haniu, Hisao
Kamanaka, Takayuki
Takizawa, Takashi
Sobajima, Atsushi
Yoshida, Kazushige
Aoki, Kaoru
Okamoto, Masanori
Kato, Hiroyuki
Saito, Naoto
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Haniu, Hisao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Takizawa, Takashi |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Yoshida, Kazushige |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Aoki, Kaoru |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Okamoto, Masanori |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kato, Hiroyuki |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Saito, Naoto |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
| 出版者 |
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出版者 |
MDPI AG |
| 引用 |
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内容記述 |
MATERIALS. 10(1):33 (2017) |
| 書誌情報 |
MATERIALS
巻 10,
号 1,
p. 33,
発行日 2017-01
|
| 抄録 |
|
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内容記述 |
The unidirectional porous hydroxyapatite HAp (UDPHAp) is a scaffold with continuous communicated pore structure in the axial direction. We evaluated and compared the ability of the UDPHAp as a three-dimensional (3D) bone tissue engineering scaffold to the interconnected calcium porous HAp ceramic (IP-CHA). To achieve this, we evaluated in vitro the compressive strength, controlled rhBMP-2 release behavior, adherent cell morphology, cell adhesion manner, and cell attachment of UDPHAp. As a further in vivo experiment, UDPHAp and IP-CHA with rhBMP-2 were transplanted into mouse calvarial defects to evaluate their bone-forming ability. The Results demonstrated that the maximum compressive strengths of the UDPHAp was 7.89 +/- 1.23 MPa and higher than that of IP-CHA (1.92 +/- 0.53 MPa) (p = 0.0039). However, the breaking energies were similar (8.99 +/- 2.72 vs. 13.95 +/- 5.69 mJ, p = 0.055). The UDPHAp released rhBMP-2 more gradually in vivo. Cells on the UDPHAp adhered tightly to the surface, which had grown deeply into the scaffolds. A significant increase in cell number on the UDPHAp was observed compared to the IP-CHA on day 8 (102,479 +/- 34,391 vs. 32,372 +/- 29,061 estimated cells per scaffold, p = 0.0495). In a mouse calvarial defect model, the percentages of new bone area (mature bone + trabecular bone) in the 2x field were 2.514% +/- 1.224% for the IP-CHA group and 7.045% +/- 2.055% for the UDPHAp group, and the percentage was significantly higher in the UDPHAp group (p = 0.0209). While maintaining the same strength as the IP-CHA, the UDPHAp with 84% porosity showed a high cell number, high cell invasiveness, and excellent bone formation. We believe the UDPHAp is an excellent material that can be applied to bone regenerative medicine. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1996-1944 |
| 書誌レコードID |
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識別子タイプ |
NCID |
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関連識別子 |
BB25053562 |
| PubMed |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/28772390 |
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|
関連名称 |
28772390 |
| 権利 |
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|
権利情報 |
© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394838800033 |
materials-10-00033.pdf (14.1 MB)
