Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-02-04 |
タイトル |
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タイトル |
Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.2147/IJN.S208129 |
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関連名称 |
10.2147/IJN.S208129 |
キーワード |
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主題 |
multiwalled carbon nanotubes, rasH2 transgenic mouse, carcinogenicity, organ accumulation, dispersion |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Sobajima, Atsushi
Haniu, Hisao
Nomura, Hiroki
Tanaka, Manabu
Takizawa, Takashi
Kamanaka, Takayuki
Aoki, Kaoru
Okamoto, Masanori
Yoshida, Kazushige
Sasaki, Jun
Ajima, Kumiko
Kuroda, Chika
Ishida, Haruka
Okano, Satomi
Ueda, Katsuya
Kato, Hiroyuki
Saito, Naoto
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信州大学研究者総覧へのリンク |
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氏名 |
Haniu, Hisao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
信州大学研究者総覧へのリンク |
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氏名 |
Takizawa, Takashi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Aoki, Kaoru |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Okamoto, Masanori |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Yoshida, Kazushige |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZeyVPUym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Kato, Hiroyuki |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html |
信州大学研究者総覧へのリンク |
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氏名 |
Saito, Naoto |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
出版者 |
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出版者 |
DOVE MEDICAL PRESS LTD |
引用 |
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内容記述 |
INTERNATIONAL JOURNAL OF NANOMEDICINE. 14:6465-6480 (2019) |
書誌情報 |
INTERNATIONAL JOURNAL OF NANOMEDICINE
巻 14,
p. 6465-6480,
発行日 2019-01
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抄録 |
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内容記述 |
Purpose: Multiwalled carbon nanotubes (MWCNTs) have been known to enter the circulatory system via the lungs from inhalation exposure; however, its carcinogenicity and subsequent accumulation in other organs have not been adequately reported in the literature. Moreover, the safety of MWCNTs as a biomaterial has remained a matter of debate, particularly when the material enters the circulatory system. To address these problems, we used carcinogenic rasH2 transgenic mice to intravenously administer highly dispersed MWCNTs and to evaluate their carcinogenicity and accumulation in the organs. Methods: Two types of MWCNTs (thin-and thick-MWCNTs) were intravenously administered at a high dose (approximately 0.7 mg per kg body weight) and low dose (approximately 0.07 mg per kg body weight). Results: MWCNTs showed pancreatic accumulation in 3.2% of mice administered with MWCNTs, but there was no accumulation in other organs. In addition, there was no significant difference in the incidence of tumor among the four MWCNTs-administered groups compared to the vehicle group without MWCNTs administration. Blood tests revealed elevated levels in mean red blood cell volume and mean red blood cell hemoglobin level for the MWCNTs-administered group, in addition to an increase in eotaxin. Conclusion: The present study demonstrated that the use of current technology to sufficiently disperse MWCNTs resulted in minimal organ accumulation with no evidence of carcinogenicity. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1178-2013 |
書誌レコードID |
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関連識別子 |
BA11782013 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/31616140 |
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関連名称 |
31616140 |
権利 |
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権利情報 |
© 2019 Sobajima et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution © Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000480412900003 |