| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-02-16 |
| タイトル |
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|
タイトル |
Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure |
| 言語 |
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|
言語 |
eng |
| DOI |
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|
関連識別子 |
https://doi.org/10.1038/s41598-018-23755-y |
|
|
関連名称 |
10.1038/s41598-018-23755-y |
| 資源タイプ |
|
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Yang, Mu
Liu, Yingye
Dai, Jian
Li, Lin
Ding, Xin
Xu, Zhe
Mori, Masayuki
Miyahara, Hiroki
Sawashita, Jinko
Higuchi, Keiichi
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Dai, Jian |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Mori, Masayuki |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Miyahara, Hiroki |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Higuchi, Keiichi |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html |
| 出版者 |
|
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出版者 |
NATURE PUBLISHING GROUP |
| 引用 |
|
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内容記述 |
SCIENTIFIC REPORTS.8:5620(2018) |
| 書誌情報 |
SCIENTIFIC REPORTS
巻 8,
p. 5620,
発行日 2018-04-04
|
| 抄録 |
|
|
内容記述 |
During acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) in plasma high density lipoproteins (HDL). Elevated SAA leads to reactive AA amyloidosis in animals and humans. Herein, we employed apolipoprotein A-II (ApoA-II) deficient (Apoa2(-/-)) and transgenic (Apoa2Tg) mice to investigate the potential roles of ApoA-II in lipoprotein particle formation and progression of AA amyloidosis during APR. AA amyloid deposition was suppressed in Apoa2(-/-) mice compared with wild type (WT) mice. During APR, Apoa2(-/-) mice exhibited significant suppression of serum SAA levels and hepatic Saa1 and Saa2 mRNA levels. Pathological investigation showed Apoa2(-/-) mice had less tissue damage and less inflammatory cell infiltration during APR. Total lipoproteins were markedly decreased in Apoa2(-/-) mice, while the ratio of HDL to low density lipoprotein (LDL) was also decreased. Both WT and Apoa2(-/-) mice showed increases in LDL and very large HDL during APR. SAA was distributed more widely in lipoprotein particles ranging from chylomicrons to very small HDL in Apoa2(-/-) mice. Our observations uncovered the critical roles of ApoA-II in inflammation, serum lipoprotein stability and AA amyloidosis morbidity, and prompt consideration of therapies for AA and other amyloidoses, whose precursor proteins are associated with circulating HDL particles. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2045-2322 |
| PubMed |
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|
識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/29618729 |
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|
関連名称 |
29618729 |
| 権利 |
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|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000429095600029 |
16K07086_04.pdf (2.6 MB)
