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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure

http://hdl.handle.net/10091/00022534
http://hdl.handle.net/10091/00022534
bc40cc02-e531-490b-8258-5ac752a8abfe
名前 / ファイル ライセンス アクション
16K07086_04.pdf 16K07086_04.pdf (2.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-16
タイトル
言語 en
タイトル Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yang, Mu

× Yang, Mu

WEKO 110338

en Yang, Mu

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Liu, Yingye

× Liu, Yingye

WEKO 110339

en Liu, Yingye

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Dai, Jian

× Dai, Jian

WEKO 110340

en Dai, Jian

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Li, Lin

× Li, Lin

WEKO 110341

en Li, Lin

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Ding, Xin

× Ding, Xin

WEKO 110342

en Ding, Xin

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Xu, Zhe

× Xu, Zhe

WEKO 110343

en Xu, Zhe

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Mori, Masayuki

× Mori, Masayuki

WEKO 110344

en Mori, Masayuki

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Miyahara, Hiroki

× Miyahara, Hiroki

WEKO 110345

en Miyahara, Hiroki

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Sawashita, Jinko

× Sawashita, Jinko

WEKO 110346

en Sawashita, Jinko

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Higuchi, Keiichi

× Higuchi, Keiichi

WEKO 110347

en Higuchi, Keiichi

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信州大学研究者総覧へのリンク
氏名 Dai, Jian
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ZacNuhkh.html
信州大学研究者総覧へのリンク
氏名 Mori, Masayuki
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html
信州大学研究者総覧へのリンク
氏名 Miyahara, Hiroki
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.OhLmPNym.html
信州大学研究者総覧へのリンク
氏名 Higuchi, Keiichi
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS.8:5620(2018)
書誌情報 SCIENTIFIC REPORTS

巻 8, p. 5620, 発行日 2018-04-04
抄録
内容記述タイプ Abstract
内容記述 During acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) in plasma high density lipoproteins (HDL). Elevated SAA leads to reactive AA amyloidosis in animals and humans. Herein, we employed apolipoprotein A-II (ApoA-II) deficient (Apoa2(-/-)) and transgenic (Apoa2Tg) mice to investigate the potential roles of ApoA-II in lipoprotein particle formation and progression of AA amyloidosis during APR. AA amyloid deposition was suppressed in Apoa2(-/-) mice compared with wild type (WT) mice. During APR, Apoa2(-/-) mice exhibited significant suppression of serum SAA levels and hepatic Saa1 and Saa2 mRNA levels. Pathological investigation showed Apoa2(-/-) mice had less tissue damage and less inflammatory cell infiltration during APR. Total lipoproteins were markedly decreased in Apoa2(-/-) mice, while the ratio of HDL to low density lipoprotein (LDL) was also decreased. Both WT and Apoa2(-/-) mice showed increases in LDL and very large HDL during APR. SAA was distributed more widely in lipoprotein particles ranging from chylomicrons to very small HDL in Apoa2(-/-) mice. Our observations uncovered the critical roles of ApoA-II in inflammation, serum lipoprotein stability and AA amyloidosis morbidity, and prompt consideration of therapies for AA and other amyloidoses, whose precursor proteins are associated with circulating HDL particles.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/29618729
関連名称 29618729
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-018-23755-y
関連名称 10.1038/s41598-018-23755-y
権利
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000429095600029
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