| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-02-22 |
| タイトル |
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タイトル |
Peripherally acting mu-opioid antagonist for the treatment of opioid-induced constipation: Systematic review and meta-analysis |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.1111/jgh.14586 |
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関連名称 |
10.1111/jgh.14586 |
| キーワード |
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主題 |
meta-analysis, opioid-induced constipation, peripherally acting mu-opioid antagonist |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Nishie, Kenichi
Yamamoto, Shuhei
Yamaga, Takayoshi
Horigome, Naoto
Hanaoka, Masayuki
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| 信州大学研究者総覧へのリンク |
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氏名 |
Hanaoka, Masayuki |
|
URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html |
| 出版者 |
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出版者 |
WILEY |
| 引用 |
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内容記述 |
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY.34(5):818-829(2019) |
| 書誌情報 |
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
巻 34,
号 5,
p. 818-829,
発行日 2018-12-29
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| 抄録 |
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内容記述 |
Background and Aim Opioid-induced constipation (OIC) is a frequent adverse event (AE) that impairs patients' quality of life (QOL). Peripherally acting mu-opioid receptor antagonists (PAMORAs) have been recognized as a treatment option for OIC, but the effect consistent across the studies has not been evaluated. Methods We conducted a quantitative meta-analysis to explore the efficacy of PAMORA for OIC (registered with PROSPERO: CRD42018085298). We systematically searched randomized controlled trials (RCTs) in Medline, Embase, and Central databases. Change from baseline in spontaneous bowel movements, pooled proportion of responders, QOL, and AEs were calculated and compared with results in placebo cases. Results We included 31 RCTs with 7849 patients. A meta-analysis revealed that patients under PAMORA therapy had considerably improved spontaneous bowel movement from baseline compared with those given placebo (20 RCTs; mean difference, 1.43; 95% confidence interval [CI], 1.18-1.68; n = 5622) and more responded (21 RCTs; risk ratio [RR], 1.81; 95% CI, 1.55-2.12; n = 4821). Moreover, QOL of patients receiving PAMORA was significantly better (8 RCTs; mean difference, -0.22; 95% CI, -0.28 to -0.17; n = 2884). AEs were increased significantly in the PAMORA group (26 RCTs; RR, 1.10; 95% CI, 1.06-1.15; n = 7715), especially in gastrointestinal disorders, whereas serious AEs were not significant (17 RCTs; RR, 1.04; 95% CI, 0.85-1.28; n = 5890). Conclusion Peripherally acting mu-opioid receptor antagonist has been shown to be effective and durable for patients with OIC and is the only drug with confirmed evidence in meta-analysis. The possibility of publication bias was the limitation of this study. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0815-9319 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10727383 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pubmed/30597600 |
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関連名称 |
30597600 |
| 権利 |
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権利情報 |
This is the peer reviewed version of the following article: Nishie, K., Yamamoto, S., Yamaga, T., Horigome, N., and Hanaoka, M. (2019) Peripherally acting μ‐opioid antagonist for the treatment of opioid‐induced constipation: Systematic review and meta‐analysis. Journal of Gastroenterology and Hepatology, 34: 818? 829. https://doi.org/10.1111/jgh.14586, which has been published in final form at https://doi.org/10.1111/jgh.14586. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000466565500007 |
16K09532_01.pdf (631.9 kB)
