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Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
http://hdl.handle.net/10091/13514
http://hdl.handle.net/10091/1351416e149b1-d8fb-4563-b622-dee219ac0bfd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Effect_dispersants_multi-walled_carbon_nanotubes.pdf (4.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-16 | |||||
| タイトル | ||||||
| タイトル | Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2147/IJN.S26573 | |||||
| 関連名称 | 10.2147/IJN.S26573 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | multi-walled carbon nanotube | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytotoxicity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intracellular concentration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dispersant | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokine secretion | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Haniu, Hisao
× Haniu, Hisao× Saito, Naoto× Matsuda, Yoshikazu× Kim, Yoong-Ahm× Park, Ki Chul× Tsukahara, Tamotsu× Usui, Yuki× Aoki, Kaoru× Shimizu, Masayuki× Ogihara, Nobuhide× Hara, Kazuo× Takanashi, Seiji× Okamoto, Masanori× Ishigaki, Norio× Nakamura, Koichi× Kato, Hiroyuki |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Haniu, Hisao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Saito, Naoto | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kato, Hiroyuki | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html | |||||
| 出版者 | ||||||
| 出版者 | Dove Medical Press | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Journal of Nanomedicine. 6(1):3295-3307 (2011) | |||||
| 書誌情報 |
International Journal of Nanomedicine 巻 1, 号 6, p. 3295-3307, 発行日 2011-12-09 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although there have been many reports about the cytotoxicity of multi-walled carbon nanotubes (MWCNTs), the results are still controversial. To investigate one possible reason, the authors investigated the influence of MWCNT dispersants on cellular uptake and cytotoxicity. Cytotoxicity was examined (measured by alamarBlue® assay), as well as intracellular MWCNT concentration and cytokine secretion (measured by flow cytometry) in human bronchial epithelial cells (BEAS-2B) exposed to a type of highly purified MWCNT vapor grown carbon fiber (VGCF®, Showa Denko Kabushiki-gaisha, Tokyo, Japan) in three different dispersants (gelatin, carboxylmethyl cellulose, and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine). The authors also researched the relationship between the intracellular concentration of MWCNTs and cytotoxicity by using two cell lines, BEAS-2B and MESO-1 human malignant pleural mesothelioma cells. The intracellular concentration of VGCF was different for each of the three dispersants, and the levels of cytotoxicity and inflammatory response were correlated with the intracellular concentration of VGCF. A relationship between the intracellular concentration of VGCF and cytotoxic effects was observed in both cell lines. The results indicate that dispersants affect VGCF uptake into cells and that cytotoxicity depends on the intracellular concentration of VGCF, not on the exposed dosage. Thus, toxicity appears to depend on exposure time, even at low VGCF concentrations, because VGCF is biopersistent. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1176-9114 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1215861X | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22228997/ | |||||
| 関連名称 | 22228997 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
