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Methods: Using Western blot analysis, we determined DJ-1 protein levels in two different types of cells (one capable and the other incapable of HTT2800 endocytosis). Using quantitative real-time polymerase chain reaction, we also investigated the ability of purified nanotubes to alter DJ-1 mRNA levels. Results: We demonstrated that the DJ-1 protein concentration was reduced, regardless of the cytotoxic activity of intracellular HTT2800. Furthermore, HTT2800 decreased the DJ-1 mRNA levels in a dose-dependent manner. This decrease in DJ-1 mRNA levels was not observed in the case of Sumi black or cup-stacked carbon nanotubes. Conclusion: These data indicate that modification of DJ-1 expression is caused by the cell response to MWCNTs. 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DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
http://hdl.handle.net/10091/13345
99517f8d-e258-4d50-b1cb-a1740e780884
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-11-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multiwalled carbon nanotubes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DJ-1 protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Western blot | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quantitative real-time polymerase chain reaction | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Haniu, Hisao
× Haniu, Hisao× Tsukahara, Tamotsu× Matsuda, Yoshikazu× Usui, Yuki× Aoki, Kaoru× Shimizu, Masayuki× Ogihara, Nobuhide× Hara, Kazuo× Takanashi, Seiji× Okamoto, Masanori× Ishigaki, Norio× Nakamura, Koichi× Kato, Hiroyuki× Saito, Naoto |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Haniu, Hisao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Kato, Hiroyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Saito, Naoto | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html | |||||
出版者 | ||||||
出版者 | Dove Medical Press | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Nanomedicine. 6(1):2689-2695 (2011) | |||||
書誌情報 |
International Journal of Nanomedicine 巻 1, 号 6, p. 2689-2695, 発行日 2011-11-04 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1176-9114 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1215861X | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22114499/ | |||||
関連名称 | ||||||
関連名称 | 22114499 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2147/IJN.S25471 | |||||
関連名称 | ||||||
関連名称 | 10.2147/IJN.S25471 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000297683900001 |