{"_buckets": {"deposit": "dfad27b5-644c-43eb-8fe3-9817d23f0876"}, "_deposit": {"id": "364", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "364"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00000364"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "2695", "bibliographicPageStart": "2689", "bibliographicVolumeNumber": "1", "bibliographic_titles": [{"bibliographic_title": "International Journal of Nanomedicine"}]}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "International Journal of Nanomedicine. 6(1):2689-2695 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Haniu, Hisao", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"}, {"subitem_link_text": "Kato, Hiroyuki", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html"}, {"subitem_link_text": "Saito, Naoto", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000297683900001"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Dove Medical Press"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "22114499"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=22114499", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2147/IJN.S25471"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.2147/IJN.S25471", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1176-9114", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1176-9114", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1215861X", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "multiwalled carbon nanotubes; DJ-1 protein; Western blot; quantitative real-time polymerase chain reaction"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "HEALTH-RISK; CELL-LINES; ASBESTOS; NEUROPROTECTION; MESOTHELIOMA; TOXICITY; STRESS; CANCER; CAVITY"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background: In the present study, we investigated whether DJ-1 could serve as a biomarker for assessing the biocompatibility of multiwalled carbon nanotubes (MWCNTs), using the highly purified carbon nanotube, HTT2800. Methods: Using Western blot analysis, we determined DJ-1 protein levels in two different types of cells (one capable and the other incapable of HTT2800 endocytosis). Using quantitative real-time polymerase chain reaction, we also investigated the ability of purified nanotubes to alter DJ-1 mRNA levels. Results: We demonstrated that the DJ-1 protein concentration was reduced, regardless of the cytotoxic activity of intracellular HTT2800. Furthermore, HTT2800 decreased the DJ-1 mRNA levels in a dose-dependent manner. This decrease in DJ-1 mRNA levels was not observed in the case of Sumi black or cup-stacked carbon nanotubes. Conclusion: These data indicate that modification of DJ-1 expression is caused by the cell response to MWCNTs. We conclude that DJ-1 is a promising candidate biomarker for the development of biocompatible MWCNTs."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Haniu,  Hisao"}], "nameIdentifiers": [{"nameIdentifier": "949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukahara,  Tamotsu"}], "nameIdentifiers": [{"nameIdentifier": "950", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Yoshikazu"}], "nameIdentifiers": [{"nameIdentifier": "951", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usui,  Yuki"}], "nameIdentifiers": [{"nameIdentifier": "952", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki,  Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu,  Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "954", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogihara,  Nobuhide"}], "nameIdentifiers": [{"nameIdentifier": "955", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara,  Kazuo"}], "nameIdentifiers": [{"nameIdentifier": "956", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takanashi,  Seiji"}], "nameIdentifiers": [{"nameIdentifier": "957", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto,  Masanori"}], "nameIdentifiers": [{"nameIdentifier": "958", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishigaki,  Norio"}], "nameIdentifiers": [{"nameIdentifier": "959", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura,  Koichi"}], "nameIdentifiers": [{"nameIdentifier": "960", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato,  Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "961", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito,  Naoto"}], "nameIdentifiers": [{"nameIdentifier": "962", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "dj1_potential_biomarker_development_biocomp.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_9", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "dj1_potential_biomarker_development_biocomp.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/364/files/dj1_potential_biomarker_development_biocomp.pdf"}, "version_id": "e29492d4-b7c1-4c64-91c6-25d45df1d4e5"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "multiwalled carbon nanotubes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DJ-1 protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Western blot", "subitem_subject_scheme": "Other"}, {"subitem_subject": "quantitative real-time polymerase chain reaction", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes"}]}, "item_type_id": "6", "owner": "1", "path": ["30/31"], "permalink_uri": "http://hdl.handle.net/10091/13345", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2011-11-21"}, "publish_date": "2011-11-21", "publish_status": "0", "recid": "364", "relation": {}, "relation_version_is_last": true, "title": ["DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes"], "weko_shared_id": 3}