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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells

http://hdl.handle.net/10091/18414
9f3293c8-c657-4c6b-a04f-5cf99e110a9f
名前 / ファイル ライセンス アクション
Endocytosis_of_Multiwalled_Carbon.pdf Endocytosis_of_Multiwalled_Carbon.pdf (3.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-06-03
タイトル
言語 en
タイトル Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Maruyama, Kayo

× Maruyama, Kayo

WEKO 6130

en Maruyama, Kayo

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 6131

en Haniu, Hisao

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Saito, Naoto

× Saito, Naoto

WEKO 6132

en Saito, Naoto

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 6133

en Matsuda, Yoshikazu

Search repository
Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 6134

en Tsukahara, Tamotsu

Search repository
Kobayashi, Shinsuke

× Kobayashi, Shinsuke

WEKO 6135

en Kobayashi, Shinsuke

Search repository
Tanaka, Manabu

× Tanaka, Manabu

WEKO 6136

en Tanaka, Manabu

Search repository
Aoki, Kaoru

× Aoki, Kaoru

WEKO 6137

en Aoki, Kaoru

Search repository
Takanashi, Seiji

× Takanashi, Seiji

WEKO 6138

en Takanashi, Seiji

Search repository
Okamoto, Masanori

× Okamoto, Masanori

WEKO 6139

en Okamoto, Masanori

Search repository
Kato, Hiroyuki

× Kato, Hiroyuki

WEKO 6140

en Kato, Hiroyuki

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Okamoto, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 BIOMED RESEARCH INTERNATIONAL. 2015:793186 (2015)
書誌情報 BIOMED RESEARCH INTERNATIONAL

巻 2015, p. 793186, 発行日 2015
抄録
内容記述タイプ Abstract
内容記述 Bronchial epithelial cells and mesothelial cells are crucial targets for the safety assessment of inhalation of carbon nanotubes (CNTs), which resemble asbestos particles in shape. Intrinsic properties of multiwalled CNTs (MWCNTs) are known to cause potentially hazardous effects on intracellular and extracellular pathways. These interactions alter cellular signaling and affect major cell functions, resulting in cell death, lysosome injury, reactive oxygen species production, apoptosis, and cytokine release. Furthermore, CNTs are emerging as a novel class of autophagy inducers. Thus, in this study, we focused on the mechanisms of MWCNT uptake into the human bronchial epithelial cells (HBECs) and human mesothelial cells (HMCs). We verified that MWCNTs are actively internalized into HBECs and HMCs and were accumulated in the lysosomes of the cells after 24-hour treatment. Next, we determined which endocytosis pathways (clathrin-mediated, caveolae-mediated, and macropinocytosis) were associated with MWCNT internalization by using corresponding endocytosis inhibitors, in two nonphagocytic cell lines derived from bronchial epithelial cells and mesothelioma cells. Clathrin-mediated endocytosis inhibitors significantly suppressed MWCNT uptake, whereas caveolae-mediated endocytosis and macropinocytosis were also found to be involved in MWCNT uptake. Thus, MWCNTs were positively taken up by nonphagocytic cells, and their cytotoxicity was closely related to these three endocytosis pathways.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 2314-6133
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2015/793186
関連名称
関連名称 10.1155/2015/793186
権利
権利情報 © 2015 Kayo Maruyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355513500001
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