| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2015-01-19 |
| タイトル |
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タイトル |
Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells |
| 言語 |
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言語 |
eng |
| DOI |
|
|
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関連識別子 |
https://doi.org/10.2478/s11658-014-0224-2 |
|
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関連名称 |
10.2478/s11658-014-0224-2 |
| キーワード |
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主題 |
Cyclic phosphatidic acid, Lysophosphatidic acid, Alkyl-glycerophosphate, Colon cancer cells, Cell cycle analysis, Cell proliferation, Cyclin D1, Akt phosphorylation, siRNA, Cancer treatment |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Tsukahara, Tamotsu
Haniu, Hisao
Matsuda, Yoshikazu
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Haniu, Hisao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
| 出版者 |
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出版者 |
Versita |
| 引用 |
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内容記述 |
Cellular Molecular Biology Letters. (17 Dec 2014) doi:10.1038/leu.2014.239 |
| 書誌情報 |
CELLULAR & MOLECULAR BIOLOGY LETTERS
発行日 2015-03
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| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
17 Dec 2014. [Epub ahead of print] |
| 抄録 |
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|
内容記述 |
Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenesis. This indicates that the interface between the LPA signaling pathway and the cell cycle signaling system is critical to the control of cancer cell proliferation. However, our previous study indicated that cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits the proliferation and migration of colon cancer cells. It has been reported that cPA shows several biological activities not shown by LPA. However, understanding of the detailed molecular and cellular mechanism underlying the regulation of the cell cycle by cPA is still in its infancy. In this study, we investigated the effect of cPA treatment on human DLD-1 colon cancer cells by analyzing cell cycle dynamics, gene expression, and AKT phosphorylation. Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1425-8153 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11691441 |
| PubMed |
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|
識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/25519683 |
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関連名称 |
25519683 |
| 権利 |
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権利情報 |
The final publication is available at link.springer.com. |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355146700003 |
CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf (414.2 kB)
