ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "4e36a37f-d1b1-448b-bc66-77e7fdf4b507"}, "_deposit": {"id": "3667", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3667"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003667", "sets": ["461:462"]}, "author_link": ["6182", "6183", "6184"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-03", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{"bibliographic_title": "CELLULAR \u0026 MOLECULAR BIOLOGY LETTERS"}]}]}, "item_6_description_19": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "17 Dec 2014. [Epub ahead of print]", "subitem_description_type": "Other"}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenesis. This indicates that the interface between the LPA signaling pathway and the cell cycle signaling system is critical to the control of cancer cell proliferation. However, our previous study indicated that cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits the proliferation and migration of colon cancer cells. It has been reported that cPA shows several biological activities not shown by LPA. However, understanding of the detailed molecular and cellular mechanism underlying the regulation of the cell cycle by cPA is still in its infancy. In this study, we investigated the effect of cPA treatment on human DLD-1 colon cancer cells by analyzing cell cycle dynamics, gene expression, and AKT phosphorylation. Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "Cellular Molecular Biology Letters. (17 Dec 2014) doi:10.1038/leu.2014.239", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Haniu, Hisao", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000355146700003"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Versita"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "25519683"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/25519683", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2478/s11658-014-0224-2"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.2478/s11658-014-0224-2", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at link.springer.com."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1425-8153", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1425-8153", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11691441", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Cyclic phosphatidic acid; Lysophosphatidic acid; Alkylglycerophosphate; Colon cancer cells; Cell cycle analysis; Cell proliferation; Cyclin D1; Akt phosphorylation; siRNA; Cancer treatment"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "STIMULATING FACTOR-I; LYSOPHOSPHATIDIC ACID; MECHANISMS; PROLIFERATION; ONCOGENE; SURVIVAL; GROWTH; PHASE; GAMMA"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenesis. This indicates that the interface between the LPA signaling pathway and the cell cycle signaling system is critical to the control of cancer cell proliferation. However, our previous study indicated that cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits the proliferation and migration of colon cancer cells. It has been reported that cPA shows several biological activities not shown by LPA. However, understanding of the detailed molecular and cellular mechanism underlying the regulation of the cell cycle by cPA is still in its infancy. In this study, we investigated the effect of cPA treatment on human DLD-1 colon cancer cells by analyzing cell cycle dynamics, gene expression, and AKT phosphorylation. Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsukahara,  Tamotsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6182", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haniu,  Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Yoshikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6184", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf", "filesize": [{"value": "414.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 414200.0, "url": {"label": "CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3667/files/CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf"}, "version_id": "1292bf27-c7a6-4ddc-ba74-5b6fe2ad6331"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Cyclic phosphatidic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lysophosphatidic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Alkyl-glycerophosphate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Colon cancer cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell cycle analysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell proliferation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cyclin D1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Akt phosphorylation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "siRNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cancer treatment", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/18038", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2015-01-19"}, "publish_date": "2015-01-19", "publish_status": "0", "recid": "3667", "relation": {}, "relation_version_is_last": true, "title": ["Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells

http://hdl.handle.net/10091/18038
309f0981-0b82-4d04-9f98-220b5d60dfc2
名前 / ファイル ライセンス アクション
CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf (414.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-01-19
タイトル
言語 en
タイトル Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells
言語
言語 eng
キーワード
主題Scheme Other
主題 Cyclic phosphatidic acid
キーワード
主題Scheme Other
主題 Lysophosphatidic acid
キーワード
主題Scheme Other
主題 Alkyl-glycerophosphate
キーワード
主題Scheme Other
主題 Colon cancer cells
キーワード
主題Scheme Other
主題 Cell cycle analysis
キーワード
主題Scheme Other
主題 Cell proliferation
キーワード
主題Scheme Other
主題 Cyclin D1
キーワード
主題Scheme Other
主題 Akt phosphorylation
キーワード
主題Scheme Other
主題 siRNA
キーワード
主題Scheme Other
主題 Cancer treatment
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 6182

en Tsukahara, Tamotsu

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 6183

en Haniu, Hisao

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 6184

en Matsuda, Yoshikazu

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 Versita
引用
内容記述タイプ Other
内容記述 Cellular Molecular Biology Letters. (17 Dec 2014) doi:10.1038/leu.2014.239
書誌情報 CELLULAR & MOLECULAR BIOLOGY LETTERS

発行日 2015-03
内容記述
内容記述タイプ Other
内容記述 17 Dec 2014. [Epub ahead of print]
抄録
内容記述タイプ Abstract
内容記述 Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenesis. This indicates that the interface between the LPA signaling pathway and the cell cycle signaling system is critical to the control of cancer cell proliferation. However, our previous study indicated that cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits the proliferation and migration of colon cancer cells. It has been reported that cPA shows several biological activities not shown by LPA. However, understanding of the detailed molecular and cellular mechanism underlying the regulation of the cell cycle by cPA is still in its infancy. In this study, we investigated the effect of cPA treatment on human DLD-1 colon cancer cells by analyzing cell cycle dynamics, gene expression, and AKT phosphorylation. Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1425-8153
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11691441
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/25519683
関連名称
関連名称 25519683
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.2478/s11658-014-0224-2
関連名称
関連名称 10.2478/s11658-014-0224-2
権利
権利情報 The final publication is available at link.springer.com.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355146700003
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:41:51.209596
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio