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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells

http://hdl.handle.net/10091/18038
http://hdl.handle.net/10091/18038
309f0981-0b82-4d04-9f98-220b5d60dfc2
名前 / ファイル ライセンス アクション
CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf CYCLIC_PHOSPHATIDIC_ACID_INDUCES_G0G1_ARREST.pdf (414.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-01-19
タイトル
タイトル Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells
言語
言語 eng
DOI
関連識別子 https://doi.org/10.2478/s11658-014-0224-2
関連名称 10.2478/s11658-014-0224-2
キーワード
主題 Cyclic phosphatidic acid, Lysophosphatidic acid, Alkyl-glycerophosphate, Colon cancer cells, Cell cycle analysis, Cell proliferation, Cyclin D1, Akt phosphorylation, siRNA, Cancer treatment
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

en Tsukahara, Tamotsu

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Haniu, Hisao

× Haniu, Hisao

en Haniu, Hisao

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Matsuda, Yoshikazu

× Matsuda, Yoshikazu

en Matsuda, Yoshikazu

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信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 Versita
引用
内容記述 Cellular Molecular Biology Letters. (17 Dec 2014) doi:10.1038/leu.2014.239
書誌情報 CELLULAR & MOLECULAR BIOLOGY LETTERS

発行日 2015-03
内容記述
内容記述タイプ Other
内容記述 17 Dec 2014. [Epub ahead of print]
抄録
内容記述 Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenesis. This indicates that the interface between the LPA signaling pathway and the cell cycle signaling system is critical to the control of cancer cell proliferation. However, our previous study indicated that cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits the proliferation and migration of colon cancer cells. It has been reported that cPA shows several biological activities not shown by LPA. However, understanding of the detailed molecular and cellular mechanism underlying the regulation of the cell cycle by cPA is still in its infancy. In this study, we investigated the effect of cPA treatment on human DLD-1 colon cancer cells by analyzing cell cycle dynamics, gene expression, and AKT phosphorylation. Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1425-8153
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11691441
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/25519683
関連名称 25519683
権利
権利情報 The final publication is available at link.springer.com.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355146700003
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