WEKO3
アイテム
Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
http://hdl.handle.net/10091/18037
http://hdl.handle.net/10091/18037934a2a58-3ef7-469e-a2e8-b0c810579dbd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Cyclic_Phosphatidic_Acid_Inhibits_AlkylGlycerophosphate.pdf (959.5 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-01-19 | |||||
| タイトル | ||||||
| タイトル | Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7150/ijms.9316 | |||||
| 関連名称 | 10.7150/ijms.9316 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Histone deacetylase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | coronary artery endothelial cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cyclic phosphatidic acid | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Haniu, Hisao× Matsuda, Yoshikazu |
|||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Haniu, Hisao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
| 出版者 | ||||||
| 出版者 | IVYSPRING INT PUBL | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Int. J. Med. Sci. 11(9):955-961 (2014) | |||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 巻 11, 号 9, p. 955-961, 発行日 2014 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Activation of the endothelium by alkyl-glycerophosphate (AGP) has been implicated in the development of atherosclerosis. Our previous study suggested that cyclic phosphatidic acid (cPA) inhibits arterial wall remodeling in a rat model in vivo. However, the mechanisms through which specific target genes are regulated during this process remain unclear. Here, we examined whether cPA inhibited AGP-induced expression of class I histone deacetylases (HDACs, namely HDAC1, HDAC2, HDAC3, and HDAC8), which may affect subsequent transcriptional activity of target genes. Our experimental results showed that human coronary artery endothelial cells (HCAECs) expressed high levels of HDAC2 and low levels HDAC1, HDAC3, and HDAC8. Moreover, AGP treatment induced downregulation of HDAC2 expression in HCAECs. However, cotreatment with cPA inhibited this downregulation of HDAC2 expression. Interestingly, treatment with AGP increased the expression and secretion of endogenous interleukin (IL)-6 and IL-8; however, this effect was inhibited when HCAECs were cotreated with cPA or the synthetic peroxisome proliferator-activator receptor gamma (PPARγ) antagonist T0070907. Thus, our data suggested that cPA may have beneficial effects in inflammation-related cardiovascular disease by controlling HDAC2 regulation. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1449-1907 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1197928X | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/25013374 | |||||
| 関連名称 | 25013374 | |||||
| 権利 | ||||||
| 権利情報 | © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/<br/>licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000344636600014 | |||||
