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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells

http://hdl.handle.net/10091/18036
d7ee52d3-8aae-46cf-b9f0-40db291153e5
名前 / ファイル ライセンス アクション
The_Role_of_Autophagy_as_a_Mechanism.pdf The_Role_of_Autophagy_as_a_Mechanism.pdf (897.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-01-19
タイトル
言語 en
タイトル The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells
言語
言語 eng
キーワード
主題Scheme Other
主題 autophagy
キーワード
主題Scheme Other
主題 carbon nanotube
キーワード
主題Scheme Other
主題 lung cell
キーワード
主題Scheme Other
主題 cell death
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 6188

en Tsukahara, Tamotsu

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 6189

en Matsuda, Yoshikazu

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 6190

en Haniu, Hisao

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 MDPI AG
引用
内容記述タイプ Other
内容記述 INT J MOL SCI. 16(1):40-48 (2015)
書誌情報 INT J MOL SCI

巻 16, 号 1, p. 40-48, 発行日 2015-01
抄録
内容記述タイプ Abstract
内容記述 Carbon nanotubes (CNTs) are promising nanomaterials having unique physical and chemical properties, with applications in a variety of fields. In this review, we briefly summarize the intrinsic properties of highly purified multi-walled CNTs (MWCNTs, HTT2800) and their potential hazardous effects on intracellular and extracellular pathways, which alter cellular signaling and impact major cell functions such as differentiation, reactive oxygen species (ROS) production, apoptosis, and autophagy. A recent study suggested that the induction of autophagy by CNTs causes nanotoxicity. Autophagy was recently recognized as a critical cell death pathway, and autophagosome accumulation has been found to be associated with exposure to CNTs. Although autophagy is considered as a cytoprotective process, it is often observed in association with cell death, and the relationship between autophagy and cell death remains unclear. Our recent study suggests that the levels of autophagy-related genes (LC3B) and autophagosome formation are clearly up-regulated, along with an increase in numbers of autophagosome vacuoles. This review highlights the importance of autophagy as an emerging mechanism of CNT toxicity.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1422-0067
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12038549
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/25546386
関連名称
関連名称 25546386
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/ijms16010040
関連名称
関連名称 10.3390/ijms16010040
権利
権利情報 © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access articledistributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348403100003
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