{"_buckets": {"deposit": "33d63dff-c0dc-4a2a-821b-ba7cb80669b6"}, "_deposit": {"id": "3670", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3670"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003670", "sets": ["462"]}, "author_link": ["6191", "6192", "6193", "6194"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "951", "bibliographicPageStart": "947", "bibliographicVolumeNumber": "4", "bibliographic_titles": [{"bibliographic_title": "FEBS Open Bio"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Fatty-acid-binding protein 3, muscle and heart (FABP3), also known as heart-type FABP, is a member of the family of intracellular lipid-binding proteins. It is a small cytoplasmic protein with a molecular mass of about 15 kDa. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus, where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs). In this study, using lysophosphatidic acid (LPA)-coated agarose beads, we have identified FABP3 as an LPA carrier protein in human coronary artery endothelial cells (HCAECs). Administration of LPA to HCAECs resulted in a dose-dependent increase in PPARγ activation. Furthermore, the LPA-induced PPARγ activation was abolished when the FABP3 expression was reduced using small interfering RNA (siRNA). We further show that the nuclear fraction of control HCAECs contained a significant amount of exogenously added LPA, whereas FABP3 siRNA-transfected HCAECs had a decreased level of LPA in the nucleus. 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Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. 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It is a small cytoplasmic protein with a molecular mass of about 15 kDa. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus, where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs). In this study, using lysophosphatidic acid (LPA)-coated agarose beads, we have identified FABP3 as an LPA carrier protein in human coronary artery endothelial cells (HCAECs). Administration of LPA to HCAECs resulted in a dose-dependent increase in PPAR gamma activation. Furthermore, the LPA-induced PPAR gamma activation was abolished when the FABP3 expression was reduced using small interfering RNA (siRNA). We further show that the nuclear fraction of control HCAECs contained a significant amount of exogenously added LPA, whereas FABP3 siRNA-transfected HCAECs had a decreased level of LPA in the nucleus. Taken together, these results suggest that FABP3 governs the transcriptional activities of LPA by targeting them to cognate PPAR gamma in the nucleus. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsukahara,  Ryoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haniu,  Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Yoshikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukahara,  Tamotsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6194", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Heart-type_fatty-acid-binding_protein.pdf", "filesize": [{"value": "554.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 554300.0, "url": {"label": "Heart-type_fatty-acid-binding_protein.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3670/files/Heart-type_fatty-acid-binding_protein.pdf"}, "version_id": "e9cc852e-fe05-4ff7-a44c-a1995bbb3aaa"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "FABP3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lysophosphatidic acid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HCAEC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Peroxisome proliferator-activated receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gamma", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/18035", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2015-01-19"}, "publish_date": "2015-01-19", "publish_status": "0", "recid": "3670", "relation": {}, "relation_version_is_last": true, "title": ["Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells"], "weko_shared_id": -1}