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Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
http://hdl.handle.net/10091/18035
http://hdl.handle.net/10091/18035917fa960-d9a3-4d51-9a50-ad51f7700efb
| 名前 / ファイル | ライセンス | アクション |
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Heart-type_fatty-acid-binding_protein.pdf (554.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2015-01-19 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| DOI | ||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.fob.2014.10.014 | |||||||||||||
| 関連名称 | 10.1016/j.fob.2014.10.014 | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | FABP3, Lysophosphatidic acid, HCAEC, Peroxisome proliferator-activated receptor, gamma | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | journal article | |||||||||||||
| 著者 |
Tsukahara, Ryoko
× Tsukahara, Ryoko
× Haniu, Hisao
× Matsuda, Yoshikazu
× Tsukahara, Tamotsu
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| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | Haniu, Hisao | |||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | ELSEVIER SCIENCE LONDON | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | FEBS Open Bio. 4:947-951 (2014) | |||||||||||||
| 書誌情報 |
FEBS Open Bio 巻 4, p. 947-951, 発行日 2014 |
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| 抄録 | ||||||||||||||
| 内容記述 | Fatty-acid-binding protein 3, muscle and heart (FABP3), also known as heart-type FABP, is a member of the family of intracellular lipid-binding proteins. It is a small cytoplasmic protein with a molecular mass of about 15 kDa. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus, where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs). In this study, using lysophosphatidic acid (LPA)-coated agarose beads, we have identified FABP3 as an LPA carrier protein in human coronary artery endothelial cells (HCAECs). Administration of LPA to HCAECs resulted in a dose-dependent increase in PPARγ activation. Furthermore, the LPA-induced PPARγ activation was abolished when the FABP3 expression was reduced using small interfering RNA (siRNA). We further show that the nuclear fraction of control HCAECs contained a significant amount of exogenously added LPA, whereas FABP3 siRNA-transfected HCAECs had a decreased level of LPA in the nucleus. Taken together, these results suggest that FABP3 governs the transcriptional activities of LPA by targeting them to cognate PPARγ in the nucleus. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2211-5463 | |||||||||||||
| PubMed | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/25426414 | |||||||||||||
| 関連名称 | 25426414 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | Copyright©2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This<br/>is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| WoS | ||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346278200112 | |||||||||||||
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Tsukahara, Ryoko, Haniu, Hisao, Matsuda, Yoshikazu, Tsukahara, Tamotsu, 2014, Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells: ELSEVIER SCIENCE LONDON, 947–951 p.
