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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells

http://hdl.handle.net/10091/18035
http://hdl.handle.net/10091/18035
917fa960-d9a3-4d51-9a50-ad51f7700efb
名前 / ファイル ライセンス アクション
Heart-type_fatty-acid-binding_protein.pdf Heart-type_fatty-acid-binding_protein.pdf (554.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-01-19
タイトル
タイトル Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1016/j.fob.2014.10.014
関連名称 10.1016/j.fob.2014.10.014
キーワード
主題 FABP3, Lysophosphatidic acid, HCAEC, Peroxisome proliferator-activated receptor, gamma
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Ryoko

× Tsukahara, Ryoko

en Tsukahara, Ryoko

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Haniu, Hisao

× Haniu, Hisao

en Haniu, Hisao

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Matsuda, Yoshikazu

× Matsuda, Yoshikazu

en Matsuda, Yoshikazu

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Tsukahara, Tamotsu

× Tsukahara, Tamotsu

en Tsukahara, Tamotsu

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信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 ELSEVIER SCIENCE LONDON
引用
内容記述 FEBS Open Bio. 4:947-951 (2014)
書誌情報 FEBS Open Bio

巻 4, p. 947-951, 発行日 2014
抄録
内容記述 Fatty-acid-binding protein 3, muscle and heart (FABP3), also known as heart-type FABP, is a member of the family of intracellular lipid-binding proteins. It is a small cytoplasmic protein with a molecular mass of about 15 kDa. FABPs are known to be carrier proteins for transporting fatty acids and other lipophilic substances from the cytoplasm to the nucleus, where these lipids are released to a group of nuclear receptors such as peroxisome proliferator-activated receptors (PPARs). In this study, using lysophosphatidic acid (LPA)-coated agarose beads, we have identified FABP3 as an LPA carrier protein in human coronary artery endothelial cells (HCAECs). Administration of LPA to HCAECs resulted in a dose-dependent increase in PPARγ activation. Furthermore, the LPA-induced PPARγ activation was abolished when the FABP3 expression was reduced using small interfering RNA (siRNA). We further show that the nuclear fraction of control HCAECs contained a significant amount of exogenously added LPA, whereas FABP3 siRNA-transfected HCAECs had a decreased level of LPA in the nucleus. Taken together, these results suggest that FABP3 governs the transcriptional activities of LPA by targeting them to cognate PPARγ in the nucleus.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 2211-5463
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/25426414
関連名称 25426414
権利
権利情報 Copyright©2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This<br/>is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346278200112
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Cite as

Tsukahara, Ryoko, Haniu, Hisao, Matsuda, Yoshikazu, Tsukahara, Tamotsu, 2014, Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells: ELSEVIER SCIENCE LONDON, 947–951 p.

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