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Methods Imaging and histologic finding of the bile duct were assessed for 73 patients with autoimmune pancreatitis to clarify whether IgG4-related biliary inflammation or pancreatic head swelling is associated with lower bile duct stricture. Results Lower bile duct stricture was found in 59 (81%) patients. Pancreatic head swelling was significantly more frequent among patients with lower bile duct stricture than those patients without lower bile duct stricture (53 [90%] vs 4 [29%]; P \u003c 0.01). Intraductal ultrasonography findings revealed lower bile duct wall thickening in 21 (95%) of the 22 patients with lower bile duct stricture, and the lower bile duct wall of the patients with pancreatic head swelling was significantly thicker than those patients without pancreatic head swelling (P = 0.028). Among the 38 patients with lower bile duct biopsies, 14 (37%) exhibited abundant IgG4-bearing plasma cell infiltration. Among the patients with lower bile duct stricture, an IgG4-related inflammation seemed to exert a dominant effect under limited conditions, including concomitant middle bile duct stricture and neither pancreatic swelling nor pancreatic duct stricture in the head region. Conclusions Both pancreatic head swelling and IgG4-related biliary inflammation affect lower bile duct stricture, which may be included in IgG4-related sclerosing cholangitis. 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Methods Imaging and histologic finding of the bile duct were assessed for 73 patients with autoimmune pancreatitis to clarify whether IgG4-related biliary inflammation or pancreatic head swelling is associated with lower bile duct stricture. Results Lower bile duct stricture was found in 59 (81%) patients. Pancreatic head swelling was significantly more frequent among patients with lower bile duct stricture than those patients without lower bile duct stricture (53 [90%] vs 4 [29%]; P \u003c 0.01). Intraductal ultrasonography findings revealed lower bile duct wall thickening in 21 (95%) of the 22 patients with lower bile duct stricture, and the lower bile duct wall of the patients with pancreatic head swelling was significantly thicker than those patients without pancreatic head swelling (P = 0.028). Among the 38 patients with lower bile duct biopsies, 14 (37%) exhibited abundant IgG4-bearing plasma cell infiltration. Among the patients with lower bile duct stricture, an IgG4-related inflammation seemed to exert a dominant effect under limited conditions, including concomitant middle bile duct stricture and neither pancreatic swelling nor pancreatic duct stricture in the head region. Conclusions Both pancreatic head swelling and IgG4-related biliary inflammation affect lower bile duct stricture, which may be included in IgG4-related sclerosing cholangitis. Pancreatic head swelling affects IgG4-related biliary wall thickening."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Watanabe, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6239", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Masahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6240", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Tetsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6241", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Masafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6242", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Muraki, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6243", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamano, Hideaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6244", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arakura, Norikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6245", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasebe, Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6246", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawa, Shigeyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6247", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Mechanisms_Lower_Bile_Duct_Stricture.pdf", "filesize": [{"value": "419.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 419000.0, "url": {"label": "Mechanisms_Lower_Bile_Duct_Stricture.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3675/files/Mechanisms_Lower_Bile_Duct_Stricture.pdf"}, "version_id": "6abdfd75-eab4-469a-b67c-59b31b4f7b05"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "autoimmune pancreatitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgG4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgG4-related sclerosing cholangitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgG4-related disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Mechanisms of Lower Bile Duct Stricture in Autoimmune Pancreatitis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mechanisms of Lower Bile Duct Stricture in Autoimmune Pancreatitis", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/17845", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-09-05"}, "publish_date": "2014-09-05", "publish_status": "0", "recid": "3675", "relation": {}, "relation_version_is_last": true, "title": ["Mechanisms of Lower Bile Duct Stricture in Autoimmune Pancreatitis"], "weko_shared_id": -1}
Mechanisms of Lower Bile Duct Stricture in Autoimmune Pancreatitis
http://hdl.handle.net/10091/17845
http://hdl.handle.net/10091/17845ca4a5588-5d98-4cf3-a6da-1e812b2702e6
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-09-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Mechanisms of Lower Bile Duct Stricture in Autoimmune Pancreatitis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune pancreatitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgG4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgG4-related sclerosing cholangitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgG4-related disease | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Watanabe, Takayuki
× Watanabe, Takayuki× Maruyama, Masahiro× Ito, Tetsuya× Maruyama, Masafumi× Muraki, Takashi× Hamano, Hideaki× Arakura, Norikazu× Hasebe, Osamu× Kawa, Shigeyuki |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Kawa, Shigeyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html | |||||
出版者 | ||||||
出版者 | LIPPINCOTT WILLIAMS & WILKINS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PANCREAS. 43(2):255-260 (2014) | |||||
書誌情報 |
PANCREAS 巻 43, 号 2, p. 255-260, 発行日 2014-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives We attempted to clarify the mechanism underlying lower bile duct stricture in autoimmune pancreatitis. Methods Imaging and histologic finding of the bile duct were assessed for 73 patients with autoimmune pancreatitis to clarify whether IgG4-related biliary inflammation or pancreatic head swelling is associated with lower bile duct stricture. Results Lower bile duct stricture was found in 59 (81%) patients. Pancreatic head swelling was significantly more frequent among patients with lower bile duct stricture than those patients without lower bile duct stricture (53 [90%] vs 4 [29%]; P < 0.01). Intraductal ultrasonography findings revealed lower bile duct wall thickening in 21 (95%) of the 22 patients with lower bile duct stricture, and the lower bile duct wall of the patients with pancreatic head swelling was significantly thicker than those patients without pancreatic head swelling (P = 0.028). Among the 38 patients with lower bile duct biopsies, 14 (37%) exhibited abundant IgG4-bearing plasma cell infiltration. Among the patients with lower bile duct stricture, an IgG4-related inflammation seemed to exert a dominant effect under limited conditions, including concomitant middle bile duct stricture and neither pancreatic swelling nor pancreatic duct stricture in the head region. Conclusions Both pancreatic head swelling and IgG4-related biliary inflammation affect lower bile duct stricture, which may be included in IgG4-related sclerosing cholangitis. Pancreatic head swelling affects IgG4-related biliary wall thickening. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0885-3177 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10674276 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24518505 | |||||
関連名称 | 24518505 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1097/01.mpa.0000437323.52598.20 | |||||
関連名称 | 10.1097/01.mpa.0000437323.52598.20 | |||||
権利 | ||||||
権利情報 | Copyright© 2014 Lippincott Williams and Wilkins / This is a non-final version of an article published in final form in PANCREAS. 43(2):255-260 (2014) | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000331556300013 |