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Corpus Callosum Atrophy in Patients with Hereditary Diffuse Leukoencephalopathy with Neuroaxonal Spheroids: An MRI-based Study
http://hdl.handle.net/10091/17831
http://hdl.handle.net/10091/1783149df27c3-0eb6-4928-958d-a78792c7d5e9
| 名前 / ファイル | ライセンス | アクション |
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Corpus_Callosum_Atrophy_Patients_Hereditary.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-09-05 | |||||
| タイトル | ||||||
| タイトル | Corpus Callosum Atrophy in Patients with Hereditary Diffuse Leukoencephalopathy with Neuroaxonal Spheroids: An MRI-based Study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2169/internalmedicine.53.0863 | |||||
| 関連名称 | 10.2169/internalmedicine.53.0863 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hereditary diffuse leukoencephalopathy with neuroaxonal spheroids | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HDLS | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | colony stimulating factor 1 receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CSF1R | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | white matter lesions | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | WMLs | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | corpus callosum atrophy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CCA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | corpus callosum index | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CCI | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kinoshita, Michiaki
× Kinoshita, Michiaki× Kondo, Yasufumi× Yoshida, Kunihiro× Fukushima, Kazuhiro× Hoshi, Ken-ichi× Ishizawa, Keisuke× Araki, Nobuo× Yazawa, Ikuru× Washimi, Yukihiko× Saitoh, Banyu× Kira, Jun-ichi× Ikeda, Shu-ichi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Yoshida, Kunihiro | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yhfNHFkh.html | |||||
| 出版者 | ||||||
| 出版者 | JAPAN SOC INTERNAL MEDICINE | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | INTERNAL MEDICINE. 53(1):21-27 (2014) | |||||
| 書誌情報 |
INTERNAL MEDICINE 巻 53, 号 1, p. 21-27, 発行日 2014 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective Hereditary diffuse leukoencephalopathy with neuroaxonal spheroids (HDLS) is an adult-onset white matter disease that presents clinically with cognitive, mental and motor dysfunction. Several autopsy reports have indicated that the corpus callosum (CC), the largest bundle of white matter, is severely affected in patients with HDLS. The aim of this study was to evaluate corpus callosum atrophy (CCA) quantitatively in HDLS patients. Methods We assessed CCA in six genetically-proven HDLS patients (HDLS group), in comparison with that observed in 20 patients with vascular dementia (VaD group) and 24 age-matched patients without organic central nervous system (CNS) disease (non-CNS group). Using midsagittal MR images, five measurements of the CC were obtained: the width of the rostrum (aa'), body (bb') and splenium (cc'), the anterior to posterior length (ab) and the maximum height (cd). Next, the corpus callosum index (CCI) was calculated as (aa' + bb' + cc')/ab. Results All HDLS patients had white matter lesions in the CC and frontoparietal lobes on the initial MRI scans. Compared with that observed in the VaD and age-matched non-CNS groups, the CCI was significantly decreased in the HDLS group (with VaD group, p < 0.01; with non-CNS group, p < 0.01). Conclusion This study showed significant atrophy of the CC in all HDLS patients on the initial MRI scans obtained 6-36 months after onset. We propose that the early appearance of CCA, frequently accompanied by high-intensity in the genu and/or splenium, on T2 images is an important diagnostic clue to HDLS. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0918-2918 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10827774 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24390523 | |||||
| 関連名称 | 24390523 | |||||
| 権利 | ||||||
| 権利情報 | Copyright© 2014 The Japanese Society of Internal Medicine | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000329409100004 | |||||
