{"_buckets": {"deposit": "52f9bcd4-0d51-46a8-a73f-12697b1d7fa4"}, "_deposit": {"id": "3684", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3684"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003684", "sets": ["461:462"]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "1236", "bibliographicPageStart": "1232", "bibliographicVolumeNumber": "131", "bibliographic_titles": [{"bibliographic_title": "ACTA OTO-LARYNGOLOGICA"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Conclusion. We have demonstrated differences in cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. The differences in cortical processing patterns between these two cases may have been influenced by the differing clinical courses and pathogenesis of hearing loss due to genetic mutations. Our results suggest the importance of hearing during early childhood for the development of a normal cortical language network. Objectives. To investigate the cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. Methods: The cortical activity of two adult patients with known genetic mutations (GJB2, SLC26A4) was evaluated with fluorodeoxyglucose-positron emission tomography (FDG-PET) with a visual language task and compared with that of normal-hearing controls. Results: A patient with a GJB2 mutation showed activation in the right auditory association area [BA21, BA22], and the left auditory association area [BA42] even with visual language task; in contrast, a patient with an SLC26A4 mutation showed no significant activation in the corresponding area.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "ACTA OTO-LARYNGOLOGICA. 131(11):1232-1236 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Moteki, Hideaki", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HNcauNkh.html"}, {"subitem_link_text": "Kitoh, Ryosuke", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uakCgpkh.html"}, {"subitem_link_text": "Nishio, Shin-ya", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uCSmPpym.html"}, {"subitem_link_text": "Takumi, Yutaka", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HNnNHhSC.html"}, {"subitem_link_text": "Usami, Shin-ichi", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZmAUHUSC.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000295581800017"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "INFORMA HEALTHCARE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21728752"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21728752", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3109/00016489.2011.593719"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.3109/00016489.2011.593719", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2011 Informa Healthcare"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0001-6489", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0001-6489", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA0050923X", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "FDG-PET; visual language task; functional brain imaging"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "POSITRON-EMISSION-TOMOGRAPHY; COCHLEAR IMPLANT USERS; AUDITORY-CORTEX; INVADER ASSAY; DEAFNESS; SPEECH; PLASTICITY; JAPANESE; PET"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Conclusion. We have demonstrated differences in cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. The differences in cortical processing patterns between these two cases may have been influenced by the differing clinical courses and pathogenesis of hearing loss due to genetic mutations. Our results suggest the importance of hearing during early childhood for the development of a normal cortical language network. Objectives. To investigate the cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. Methods: The cortical activity of two adult patients with known genetic mutations (GJB2, SLC26A4) was evaluated with fluorodeoxyglucose-positron emission tomography (FDG-PET) with a visual language task and compared with that of normal-hearing controls. Results: A patient with a GJB2 mutation showed activation in the right auditory association area [BA21, BA22], and the left auditory association area [BA42] even with visual language task; in contrast, a patient with an SLC26A4 mutation showed no significant activation in the corresponding area."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Moteki,  Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "6301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naito,  Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "6302", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujiwara,  Keizo"}], "nameIdentifiers": [{"nameIdentifier": "6303", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitoh,  Ryosuke"}], "nameIdentifiers": [{"nameIdentifier": "6304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishio,  Shin-ya"}], "nameIdentifiers": [{"nameIdentifier": "6305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oguchi,  Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "6306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takumi,  Yutaka"}], "nameIdentifiers": [{"nameIdentifier": "6307", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usami,  Shin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "6308", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Different_cortical_metabolic_activation.pdf", "filesize": [{"value": "315.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 315200.0, "url": {"label": "Different_cortical_metabolic_activation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3684/files/Different_cortical_metabolic_activation.pdf"}, "version_id": "5717b134-17bc-48e3-8059-a78333df6121"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "FDG-PET", "subitem_subject_scheme": "Other"}, {"subitem_subject": "visual language task", "subitem_subject_scheme": "Other"}, {"subitem_subject": "functional brain imaging", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Different cortical metabolic activation by visual stimuli possibly due to different time courses of hearing loss in patients with GJB2 and SLC26A4 mutations", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Different cortical metabolic activation by visual stimuli possibly due to different time courses of hearing loss in patients with GJB2 and SLC26A4 mutations"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17785", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-07-25"}, "publish_date": "2014-07-25", "publish_status": "0", "recid": "3684", "relation": {}, "relation_version_is_last": true, "title": ["Different cortical metabolic activation by visual stimuli possibly due to different time courses of hearing loss in patients with GJB2 and SLC26A4 mutations"], "weko_shared_id": null}