| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-07-23 |
| タイトル |
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タイトル |
Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.1186/1744-9081-7-23 |
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関連名称 |
10.1186/1744-9081-7-23 |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Sasayama, Daimei
Hori, Hiroaki
Iijima, Yoshimi
Teraishi, Toshiya
Hattori, Kotaro
Ota, Miho
Fujii, Takashi
Higuchi, Teruhiko
Amano, Naoji
Kunugi, Hiroshi
|
| 信州大学研究者総覧へのリンク |
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氏名 |
Sasayama, Daimei |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html |
| 出版者 |
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出版者 |
BIOMED CENTRAL LTD |
| 引用 |
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内容記述 |
BEHAVIORAL AND BRAIN FUNCTIONS. 7:23 (2011) |
| 書誌情報 |
BEHAVIORAL AND BRAIN FUNCTIONS
巻 7,
p. 23,
発行日 2011-07-05
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| 抄録 |
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内容記述 |
Background: Recently, hypothalamus-pituitary-adrenal (HPA) axis function assessed with the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test has been shown to be associated with response to antidepressant treatment. A polymorphism (rs16944) in the interleukin-1beta (IL-1 beta) gene has also been reported to be associated with the medication response in depression. These findings prompted us to examine the possible association between IL-1 beta gene polymorphisms and HPA axis function assessed with the DEX/CRH test. Methods: DEX/CRH test was performed in 179 healthy volunteers (45 males: mean age 40.5 +/- 15.8 years; 134 females: mean age 47.1 +/- 13.2 years). Five tagging single nucleotide polymorphisms (SNPs) of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were selected at an r(2) threshold of 0.80 with a minor allele frequency > 0.1. Genotyping was performed by the TaqMan allelic discrimination assay. A two-way factorial analysis of variance (ANOVA) was performed with the DEX/CRH test results as the dependent variable and genotype and gender as independent variables. To account for multiple testing, P values < 0.01 were considered statistically significant for associations between the genotypes and the cortisol levels. Results: The cortisol levels after DEX administration (DST-Cortisol) showed significant associations with the genotypes of rs16944 (P = 0.00049) and rs1143633 (P = 0.0060), with no significant gender effect or genotype x gender interaction. On the other hand, cortisol levels after CRH administration (DEX/CRH-Cortisol) were affected by gender but were not significantly influenced by the genotype of the examined SNPs, with no significant genotype x gender interaction. Conclusions: Our results suggest that genetic variations in the IL-1 beta gene contribute to the HPA axis alteration assessed by DST-Cortisol in healthy subjects. On the other hand, no significant associations of the IL-1 beta gene polymorphisms with the DEX/CRH-Cortisol were observed. Confirmation of our findings in futures studies may add new insight into the communication between the immune system and the HPA axis. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1744-9081 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12050307 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21726461 |
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関連名称 |
21726461 |
| 権利 |
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権利情報 |
Copyright© 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000292914300001 |
Modulation_cortisol_responses_DEX_CRH_test.pdf (386.7 kB)
