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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults

http://hdl.handle.net/10091/17727
http://hdl.handle.net/10091/17727
2a7f0785-3478-49c5-a9ee-0ebcb82b5862
名前 / ファイル ライセンス アクション
Modulation_cortisol_responses_DEX_CRH_test.pdf Modulation_cortisol_responses_DEX_CRH_test.pdf (386.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-23
タイトル
タイトル Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1186/1744-9081-7-23
関連名称 10.1186/1744-9081-7-23
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

en Sasayama, Daimei

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Hori, Hiroaki

× Hori, Hiroaki

en Hori, Hiroaki

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Iijima, Yoshimi

× Iijima, Yoshimi

en Iijima, Yoshimi

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Teraishi, Toshiya

× Teraishi, Toshiya

en Teraishi, Toshiya

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Hattori, Kotaro

× Hattori, Kotaro

en Hattori, Kotaro

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Ota, Miho

× Ota, Miho

en Ota, Miho

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Fujii, Takashi

× Fujii, Takashi

en Fujii, Takashi

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Higuchi, Teruhiko

× Higuchi, Teruhiko

en Higuchi, Teruhiko

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Amano, Naoji

× Amano, Naoji

en Amano, Naoji

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Kunugi, Hiroshi

× Kunugi, Hiroshi

en Kunugi, Hiroshi

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信州大学研究者総覧へのリンク
氏名 Sasayama, Daimei
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html
出版者
出版者 BIOMED CENTRAL LTD
引用
内容記述 BEHAVIORAL AND BRAIN FUNCTIONS. 7:23 (2011)
書誌情報 BEHAVIORAL AND BRAIN FUNCTIONS

巻 7, p. 23, 発行日 2011-07-05
抄録
内容記述 Background: Recently, hypothalamus-pituitary-adrenal (HPA) axis function assessed with the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test has been shown to be associated with response to antidepressant treatment. A polymorphism (rs16944) in the interleukin-1beta (IL-1 beta) gene has also been reported to be associated with the medication response in depression. These findings prompted us to examine the possible association between IL-1 beta gene polymorphisms and HPA axis function assessed with the DEX/CRH test. Methods: DEX/CRH test was performed in 179 healthy volunteers (45 males: mean age 40.5 +/- 15.8 years; 134 females: mean age 47.1 +/- 13.2 years). Five tagging single nucleotide polymorphisms (SNPs) of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were selected at an r(2) threshold of 0.80 with a minor allele frequency > 0.1. Genotyping was performed by the TaqMan allelic discrimination assay. A two-way factorial analysis of variance (ANOVA) was performed with the DEX/CRH test results as the dependent variable and genotype and gender as independent variables. To account for multiple testing, P values < 0.01 were considered statistically significant for associations between the genotypes and the cortisol levels. Results: The cortisol levels after DEX administration (DST-Cortisol) showed significant associations with the genotypes of rs16944 (P = 0.00049) and rs1143633 (P = 0.0060), with no significant gender effect or genotype x gender interaction. On the other hand, cortisol levels after CRH administration (DEX/CRH-Cortisol) were affected by gender but were not significantly influenced by the genotype of the examined SNPs, with no significant genotype x gender interaction. Conclusions: Our results suggest that genetic variations in the IL-1 beta gene contribute to the HPA axis alteration assessed by DST-Cortisol in healthy subjects. On the other hand, no significant associations of the IL-1 beta gene polymorphisms with the DEX/CRH-Cortisol were observed. Confirmation of our findings in futures studies may add new insight into the communication between the immune system and the HPA axis.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1744-9081
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12050307
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21726461
関連名称 21726461
権利
権利情報 Copyright© 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000292914300001
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