Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-07-23 |
タイトル |
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タイトル |
Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1186/1744-9081-7-35 |
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関連名称 |
10.1186/1744-9081-7-35 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Sasayama, Daimei
Hori, Hiroaki
Teraishi, Toshiya
Hattori, Kotaro
Ota, Miho
Iijima, Yoshimi
Tatsumi, Masahiko
Higuchi, Teruhiko
Amano, Naoji
Kunugi, Hiroshi
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信州大学研究者総覧へのリンク |
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氏名 |
Sasayama, Daimei |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html |
出版者 |
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出版者 |
BIOMED CENTRAL LTD |
引用 |
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内容記述 |
BEHAVIORAL AND BRAIN FUNCTIONS. 7:35 (2011) |
書誌情報 |
BEHAVIORAL AND BRAIN FUNCTIONS
巻 7,
p. 35,
発行日 2011-08-16
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抄録 |
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内容記述 |
Background: Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1 beta) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods: A total of 533 patients with schizophrenia (302 males: mean age +/- standard deviation 43.4 +/- 13.0 years; 233 females; mean age 44.8 +/- 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 +/- 17.3 years; 748 females; 46.3 +/- 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results: Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions: The present study shows the first evidence that the IL-1 beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1 beta gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1 beta in the etiology of schizophrenia. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1744-9081 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12050307 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21843369 |
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関連名称 |
21843369 |
権利 |
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権利情報 |
Copyright© 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294611600001 |