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Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population
http://hdl.handle.net/10091/17726
http://hdl.handle.net/10091/17726ad11b2a3-d6ce-4aa3-8e8c-700fb6dd8ef9
| 名前 / ファイル | ライセンス | アクション |
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Possible_association_Interleukin-1beta_gene.pdf (311.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2014-07-23 | |||||||||||||||||||||||||
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| タイトル | Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/1744-9081-7-35 | |||||||||||||||||||||||||
| 関連名称 | 10.1186/1744-9081-7-35 | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Sasayama, Daimei
× Sasayama, Daimei
× Hori, Hiroaki
× Teraishi, Toshiya
× Hattori, Kotaro
× Ota, Miho
× Iijima, Yoshimi
× Tatsumi, Masahiko
× Higuchi, Teruhiko
× Amano, Naoji
× Kunugi, Hiroshi
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Sasayama, Daimei | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | BIOMED CENTRAL LTD | |||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||
| 内容記述 | BEHAVIORAL AND BRAIN FUNCTIONS. 7:35 (2011) | |||||||||||||||||||||||||
| 書誌情報 |
BEHAVIORAL AND BRAIN FUNCTIONS 巻 7, p. 35, 発行日 2011-08-16 |
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | Background: Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1 beta) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods: A total of 533 patients with schizophrenia (302 males: mean age +/- standard deviation 43.4 +/- 13.0 years; 233 females; mean age 44.8 +/- 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 +/- 17.3 years; 748 females; 46.3 +/- 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results: Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions: The present study shows the first evidence that the IL-1 beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1 beta gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1 beta in the etiology of schizophrenia. | |||||||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1744-9081 | |||||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA12050307 | |||||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21843369 | |||||||||||||||||||||||||
| 関連名称 | 21843369 | |||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||
| 権利情報 | Copyright© 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294611600001 | |||||||||||||||||||||||||
