{"_buckets": {"deposit": "f68350ee-8a57-44d6-8a7a-58c140a504dc"}, "_deposit": {"id": "3689", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3689"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003689"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-08-16", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "35", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "BEHAVIORAL AND BRAIN FUNCTIONS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background: Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1 beta) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods: A total of 533 patients with schizophrenia (302 males: mean age +/- standard deviation 43.4 +/- 13.0 years; 233 females; mean age 44.8 +/- 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 +/- 17.3 years; 748 females; 46.3 +/- 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results: Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions: The present study shows the first evidence that the IL-1 beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1 beta gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1 beta in the etiology of schizophrenia.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "BEHAVIORAL AND BRAIN FUNCTIONS. 7:35 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Sasayama, Daimei", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000294611600001"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "BIOMED CENTRAL LTD"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21843369"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21843369", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1186/1744-9081-7-35"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1186/1744-9081-7-35", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1744-9081", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1744-9081", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12050307", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; SINGLE-NUCLEOTIDE POLYMORPHISMS; NECROSIS-FACTOR-ALPHA; MONONUCLEAR-CELLS; GENOME SCAN; CORTISOL RESPONSES; BIPOLAR DISORDER; COMMON VARIANTS; HEALTHY-ADULTS; DSM-IV"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Background: Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1 beta) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods: A total of 533 patients with schizophrenia (302 males: mean age +/- standard deviation 43.4 +/- 13.0 years; 233 females; mean age 44.8 +/- 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 +/- 17.3 years; 748 females; 46.3 +/- 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results: Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions: The present study shows the first evidence that the IL-1 beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1 beta gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1 beta in the etiology of schizophrenia."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasayama,  Daimei"}], "nameIdentifiers": [{"nameIdentifier": "6344", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hori,  Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "6345", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teraishi,  Toshiya"}], "nameIdentifiers": [{"nameIdentifier": "6346", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hattori,  Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "6347", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  Miho"}], "nameIdentifiers": [{"nameIdentifier": "6348", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iijima,  Yoshimi"}], "nameIdentifiers": [{"nameIdentifier": "6349", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tatsumi,  Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "6350", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi,  Teruhiko"}], "nameIdentifiers": [{"nameIdentifier": "6351", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano,  Naoji"}], "nameIdentifiers": [{"nameIdentifier": "6352", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunugi,  Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "6353", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "filename": "Possible_association_Interleukin-1beta_gene.pdf", "filesize": [{"value": "311.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3119000, "url": {"label": "Possible_association_Interleukin-1beta_gene.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3689/files/Possible_association_Interleukin-1beta_gene.pdf"}, "version_id": "e5e9e1cb-1f80-4250-91f0-2d5c50ae202a"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17726", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2014-07-23"}, "publish_date": "2014-07-23", "publish_status": "0", "recid": "3689", "relation": {}, "relation_version_is_last": true, "title": ["Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population"], "weko_shared_id": null}