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  1. 050 医学部, 大学院医学系研究科 (Faculty&Graduate School of Medicine)
  2. 0501 学術論文 (Journal Articles)

Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

http://hdl.handle.net/10091/17726
ad11b2a3-d6ce-4aa3-8e8c-700fb6dd8ef9
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名前 / ファイル ライセンス Actions
Possible_association_Interleukin-1beta_gene.pdf Possible_association_Interleukin-1beta_gene.pdf (311.9 kB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-23
タイトル
タイトル Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

WEKO 6344

Sasayama, Daimei

Search repository
Hori, Hiroaki

× Hori, Hiroaki

WEKO 6345

Hori, Hiroaki

Search repository
Teraishi, Toshiya

× Teraishi, Toshiya

WEKO 6346

Teraishi, Toshiya

Search repository
Hattori, Kotaro

× Hattori, Kotaro

WEKO 6347

Hattori, Kotaro

Search repository
Ota, Miho

× Ota, Miho

WEKO 6348

Ota, Miho

Search repository
Iijima, Yoshimi

× Iijima, Yoshimi

WEKO 6349

Iijima, Yoshimi

Search repository
Tatsumi, Masahiko

× Tatsumi, Masahiko

WEKO 6350

Tatsumi, Masahiko

Search repository
Higuchi, Teruhiko

× Higuchi, Teruhiko

WEKO 6351

Higuchi, Teruhiko

Search repository
Amano, Naoji

× Amano, Naoji

WEKO 6352

Amano, Naoji

Search repository
Kunugi, Hiroshi

× Kunugi, Hiroshi

WEKO 6353

Kunugi, Hiroshi

Search repository
信州大学研究者総覧へのリンク
Sasayama, Daimei
http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html
出版者
出版者 BIOMED CENTRAL LTD
引用
内容記述タイプ Other
内容記述 BEHAVIORAL AND BRAIN FUNCTIONS. 7:35 (2011)
書誌情報 BEHAVIORAL AND BRAIN FUNCTIONS

巻 7, p. 35, 発行日 2011-08-16
抄録
内容記述タイプ Abstract
内容記述 Background: Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1 beta) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods: A total of 533 patients with schizophrenia (302 males: mean age +/- standard deviation 43.4 +/- 13.0 years; 233 females; mean age 44.8 +/- 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 +/- 17.3 years; 748 females; 46.3 +/- 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1 beta gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results: Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions: The present study shows the first evidence that the IL-1 beta gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1 beta gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1 beta in the etiology of schizophrenia.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1744-9081
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12050307
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21843369
関連名称
関連名称 21843369
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1186/1744-9081-7-35
関連名称
関連名称 10.1186/1744-9081-7-35
権利
権利情報 Copyright© 2011 Sasayama et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版フラグ
値 publisher
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294611600001
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