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However, few studies have reported the impairment of motor dexterity in unipolar depression and bipolar disorder. In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls. Methods: Manual dexterity was assessed by the Purdue pegboard test in 98 patients with unipolar major depression, 48 euthymic or depressed patients with bipolar disorder, and 158 healthy controls, matched for age and gender. Results: Compared to healthy controls, sum of the scores of right, left, and both hands subtests (R + L+ B) was significantly lower in both patients with unipolar depression and bipolar disorder (P= 0.0034 and P\u003c0.0001, respectively). Furthermore, R + L + B was significantly lower in bipolar disorder compared to unipolar depression (P=0.0016). Lithium dose and chlorpromazine equivalent dose of antipsychotics were significantly negatively correlated with some of the subtest scores. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression

http://hdl.handle.net/10091/17720
http://hdl.handle.net/10091/17720
1b5a3ca3-5401-4143-b744-50367119701b
名前 / ファイル ライセンス アクション
More_severe_impairment_manual_dexterity.pdf More_severe_impairment_manual_dexterity.pdf (240.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-23
タイトル
言語 en
タイトル More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression
言語
言語 eng
キーワード
主題Scheme Other
主題 Unipolar depression
キーワード
主題Scheme Other
主題 Bipolar disorder
キーワード
主題Scheme Other
主題 Dexterity
キーワード
主題Scheme Other
主題 Lithium
キーワード
主題Scheme Other
主題 Antipsychotics
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

WEKO 6404

en Sasayama, Daimei

Search repository
Hori, Hiroaki

× Hori, Hiroaki

WEKO 6405

en Hori, Hiroaki

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Teraishi, Toshiya

× Teraishi, Toshiya

WEKO 6406

en Teraishi, Toshiya

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Hattori, Kotaro

× Hattori, Kotaro

WEKO 6407

en Hattori, Kotaro

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Ota, Miho

× Ota, Miho

WEKO 6408

en Ota, Miho

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Matsuo, Junko

× Matsuo, Junko

WEKO 6409

en Matsuo, Junko

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Kawamoto, Yumiko

× Kawamoto, Yumiko

WEKO 6410

en Kawamoto, Yumiko

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Kinoshita, Yukiko

× Kinoshita, Yukiko

WEKO 6411

en Kinoshita, Yukiko

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Hashikura, Miyako

× Hashikura, Miyako

WEKO 6412

en Hashikura, Miyako

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Amano, Naoji

× Amano, Naoji

WEKO 6413

en Amano, Naoji

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Higuchi, Teruhiko

× Higuchi, Teruhiko

WEKO 6414

en Higuchi, Teruhiko

Search repository
Kunugi, Hiroshi

× Kunugi, Hiroshi

WEKO 6415

en Kunugi, Hiroshi

Search repository
信州大学研究者総覧へのリンク
氏名 Sasayama, Daimei
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html
出版者
出版者 ELSEVIER SCIENCE BV
引用
内容記述タイプ Other
内容記述 JOURNAL OF AFFECTIVE DISORDERS. 136(3):1047-1052 (2012)
書誌情報 JOURNAL OF AFFECTIVE DISORDERS

巻 136, 号 3, p. 1047-1052, 発行日 2012-02
抄録
内容記述タイプ Abstract
内容記述 Background: Mood disorders are associated with various neurocognitive deficits. However, few studies have reported the impairment of motor dexterity in unipolar depression and bipolar disorder. In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls. Methods: Manual dexterity was assessed by the Purdue pegboard test in 98 patients with unipolar major depression, 48 euthymic or depressed patients with bipolar disorder, and 158 healthy controls, matched for age and gender. Results: Compared to healthy controls, sum of the scores of right, left, and both hands subtests (R + L+ B) was significantly lower in both patients with unipolar depression and bipolar disorder (P= 0.0034 and P<0.0001, respectively). Furthermore, R + L + B was significantly lower in bipolar disorder compared to unipolar depression (P=0.0016). Lithium dose and chlorpromazine equivalent dose of antipsychotics were significantly negatively correlated with some of the subtest scores. On the other hand, depression severity did not significantly correlate with any of the subtest scores. Difference in R + L+ B between unipolar depression and bipolar disorder remained statistically significant even after controlling for gender, age, lithium dose, and chlorpromazine equivalent dose (P = 0.0028). Limitations Bipolar patients during manic episode were not included in the study. Conclusions: Gross movement dexterity was impaired in both patients with unipolar depression and bipolar disorder. The severity of impairment was significantly greater in patients with bipolar disorder. The functional difference between unipolar and bipolar patients may suggest different pathological conditions between the two depressive disorders.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0165-0327
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00256633
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22169250
関連名称 22169250
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jad.2011.11.031
関連名称 10.1016/j.jad.2011.11.031
権利
権利情報 Copyright© 2011 Elsevier
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000301996000114
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