Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-07-10 |
タイトル |
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タイトル |
Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.2147/IJN.S58661 |
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関連名称 |
10.2147/IJN.S58661 |
キーワード |
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主題 |
multi-walled carbon nanotube, cup-stacked carbon nanotube, cytotoxicity, in vitro, intracellular acidity |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Haniu, Hisao
Saito, Naoto
Matsuda, Yoshikazu
Tsukahara, Tamotsu
Usui, Yuki
Maruyama, Kayo
Takanashi, Seiji
Aoki, Kaoru
Kobayashi, Shinsuke
Nomura, Hiroki
Tanaka, Manabu
Okamoto, Masanori
Kato, Hiroyuki
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信州大学研究者総覧へのリンク |
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氏名 |
Haniu, Hisao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
信州大学研究者総覧へのリンク |
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氏名 |
Saito, Naoto |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Aoki, Kaoru |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Okamoto, Masanori |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Kato, Hiroyuki |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html |
出版者 |
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出版者 |
DOVE MEDICAL PRESS LTD |
引用 |
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内容記述 |
INTERNATIONAL JOURNAL OF NANOMEDICINE. 9:1979-1990 (2014) |
書誌情報 |
INTERNATIONAL JOURNAL OF NANOMEDICINE
巻 9,
p. 1979-1990,
発行日 2014
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抄録 |
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内容記述 |
This study aimed to investigate the influence of the shape and size of multi-walled carbon nanotubes (MWCNTs) and cup-stacked carbon nanotubes (CSCNTs) on biological responses in vitro. Three types of MWCNTs - VGCF (R)-X, VGCF (R)-S, and VGCF (R) (vapor grown carbon fibers; with diameters of 15, 80, and 150 nm, respectively) - and three CSCNTs of different lengths (CS-L, 20-80 mu m; CS-S, 0.5-20 mu m; and CS-M, of intermediate length) were tested. Human bronchial epithelial (BEAS-2B) and malignant pleural mesothelioma cells were exposed to the CNTs (1-50 mu g/mL), and cell viability, permeability, uptake, total reactive oxygen species/superoxide production, and intracellular acidity were measured. CSCNTs were less toxic than MWCNTs in both cell types over a 24-hour exposure period. The cytotoxicity of endocytosed MWCNTs varied according to cell type/size, while that of CSCNTs depended on tube length irrespective of cell type. CNT diameter and length influenced cell aggregation and injury extent. Intracellular acidity increased independently of lysosomal activity along with the number of vacuoles in BEAS-2B cells exposed for 24 hours to either CNT (concentration, 10 mu g/mL). However, total reactive oxygen species/superoxide generation did not contribute to cytotoxicity. The results demonstrate that CSCNTs could be suitable for biological applications and that CNT shape and size can have differential effects depending on cell type, which can be exploited in the development of highly specialized, biocompatible CNTs. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1178-2013 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/24790438 |
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関連名称 |
24790438 |
権利 |
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権利情報 |
Copyright© 2014 Haniu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution ? Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000334914100001 |