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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells

http://hdl.handle.net/10091/17716
1c682864-15ce-4d8e-b093-d4f941031eea
名前 / ファイル ライセンス アクション
Biological_responses_according_shape_size.pdf Biological_responses_according_shape_size.pdf (4.2 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-10
タイトル
言語 en
タイトル Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
言語
言語 eng
キーワード
主題Scheme Other
主題 multi-walled carbon nanotube
キーワード
主題Scheme Other
主題 cup-stacked carbon nanotube
キーワード
主題Scheme Other
主題 cytotoxicity
キーワード
主題Scheme Other
主題 in vitro
キーワード
主題Scheme Other
主題 intracellular acidity
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Haniu, Hisao

× Haniu, Hisao

WEKO 6431

en Haniu, Hisao

Search repository
Saito, Naoto

× Saito, Naoto

WEKO 6432

en Saito, Naoto

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 6433

en Matsuda, Yoshikazu

Search repository
Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 6434

en Tsukahara, Tamotsu

Search repository
Usui, Yuki

× Usui, Yuki

WEKO 6435

en Usui, Yuki

Search repository
Maruyama, Kayo

× Maruyama, Kayo

WEKO 6436

en Maruyama, Kayo

Search repository
Takanashi, Seiji

× Takanashi, Seiji

WEKO 6437

en Takanashi, Seiji

Search repository
Aoki, Kaoru

× Aoki, Kaoru

WEKO 6438

en Aoki, Kaoru

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Kobayashi, Shinsuke

× Kobayashi, Shinsuke

WEKO 6439

en Kobayashi, Shinsuke

Search repository
Nomura, Hiroki

× Nomura, Hiroki

WEKO 6440

en Nomura, Hiroki

Search repository
Tanaka, Manabu

× Tanaka, Manabu

WEKO 6441

en Tanaka, Manabu

Search repository
Okamoto, Masanori

× Okamoto, Masanori

WEKO 6442

en Okamoto, Masanori

Search repository
Kato, Hiroyuki

× Kato, Hiroyuki

WEKO 6443

en Kato, Hiroyuki

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Okamoto, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
出版者
出版者 DOVE MEDICAL PRESS LTD
引用
内容記述タイプ Other
内容記述 INTERNATIONAL JOURNAL OF NANOMEDICINE. 9:1979-1990 (2014)
書誌情報 INTERNATIONAL JOURNAL OF NANOMEDICINE

巻 9, p. 1979-1990, 発行日 2014
抄録
内容記述タイプ Abstract
内容記述 This study aimed to investigate the influence of the shape and size of multi-walled carbon nanotubes (MWCNTs) and cup-stacked carbon nanotubes (CSCNTs) on biological responses in vitro. Three types of MWCNTs - VGCF (R)-X, VGCF (R)-S, and VGCF (R) (vapor grown carbon fibers; with diameters of 15, 80, and 150 nm, respectively) - and three CSCNTs of different lengths (CS-L, 20-80 mu m; CS-S, 0.5-20 mu m; and CS-M, of intermediate length) were tested. Human bronchial epithelial (BEAS-2B) and malignant pleural mesothelioma cells were exposed to the CNTs (1-50 mu g/mL), and cell viability, permeability, uptake, total reactive oxygen species/superoxide production, and intracellular acidity were measured. CSCNTs were less toxic than MWCNTs in both cell types over a 24-hour exposure period. The cytotoxicity of endocytosed MWCNTs varied according to cell type/size, while that of CSCNTs depended on tube length irrespective of cell type. CNT diameter and length influenced cell aggregation and injury extent. Intracellular acidity increased independently of lysosomal activity along with the number of vacuoles in BEAS-2B cells exposed for 24 hours to either CNT (concentration, 10 mu g/mL). However, total reactive oxygen species/superoxide generation did not contribute to cytotoxicity. The results demonstrate that CSCNTs could be suitable for biological applications and that CNT shape and size can have differential effects depending on cell type, which can be exploited in the development of highly specialized, biocompatible CNTs.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1178-2013
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24790438
関連名称
関連名称 24790438
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.2147/IJN.S58661
関連名称
関連名称 10.2147/IJN.S58661
権利
権利情報 Copyright© 2014 Haniu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution ? Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000334914100001
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