{"_buckets": {"deposit": "271f0b3a-b172-4730-a3e1-c0a22448e4fa"}, "_deposit": {"id": "3699", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3699"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003699", "sets": ["462"]}, "author_link": ["6446", "6447", "6448", "6449", "6450", "6451", "6452", "6453", "6454", "6455", "6456"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "346", "bibliographicPageStart": "342", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "CANCER SCIENCE"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Large granular lymphocyte leukemia (LGLL) has been morphologically characterized as a group of lymphoproliferative diseases that include T-cell large granular lymphocytic leukemia (T-LGLL) and chronic lymphoproliferative disorders of natural killer cells (CLPD-NK). We investigated mutations in the Src homology 2 (SH2) domain of the signal transducer and activator of transcription 3 (STAT3) gene in Asian cohorts of T-LGLL and CLPD-NK (n=42 and 11, respectively). Two mutations, Y640F and D661Y, were identified using direct sequencing or allele-specific (AS) PCR. Y640F and D661Y mutations were found in seven and 18 patients, respectively. Two patients were positive for both mutations. Frequencies of STAT3 mutations in T-LGLL and CLPD-NK were 47.6% and 27.2%, respectively. Pure red cell aplasia (PRCA) was associated with the mutations (P=0.005). The mutations were persistently found at stable levels in some patients after more than 5years using AS-quantitative PCR. The results of the present study indicate that the SH2 domain of the STAT3 gene is frequently mutated in Asian T-LGLL and CLPD-NK, and that PRCA is closely correlated with the mutations. SH2 domain of the STAT3 gene is frequently mutated in Asian T cell large granular lymphocyte leukemia and chronic lymphoproliferative disorders of NK cells. Pure red cell aplasia is closely associated with the mutations.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "CANCER SCIENCE. 105(3):342-346 (2014)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Ishida, Fumihiro", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ueTCHhkh.html"}, {"subitem_link_text": "Sekiguchi, Nodoka", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yNTUbhym.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000333670000013"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "WILEY-BLACKWELL"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "24350896"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/24350896", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/cas.12341"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/cas.12341", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright© 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1349-7006", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1349-7006", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12100165", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Cytotoxic T cell; large granular lymphocyte leukemia; natural killer cell; pure red cell aplasia; STAT3"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "LYMPHOPROLIFERATIVE DISEASE; PROLIFERATIVE DISORDERS; EXPRESSION; ANEMIA; JAPAN"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Large granular lymphocyte leukemia (LGLL) has been morphologically characterized as a group of lymphoproliferative diseases that include T-cell large granular lymphocytic leukemia (T-LGLL) and chronic lymphoproliferative disorders of natural killer cells (CLPD-NK). We investigated mutations in the Src homology 2 (SH2) domain of the signal transducer and activator of transcription 3 (STAT3) gene in Asian cohorts of T-LGLL and CLPD-NK (n=42 and 11, respectively). Two mutations, Y640F and D661Y, were identified using direct sequencing or allele-specific (AS) PCR. Y640F and D661Y mutations were found in seven and 18 patients, respectively. Two patients were positive for both mutations. Frequencies of STAT3 mutations in T-LGLL and CLPD-NK were 47.6% and 27.2%, respectively. Pure red cell aplasia (PRCA) was associated with the mutations (P=0.005). The mutations were persistently found at stable levels in some patients after more than 5years using AS-quantitative PCR. The results of the present study indicate that the SH2 domain of the STAT3 gene is frequently mutated in Asian T-LGLL and CLPD-NK, and that PRCA is closely correlated with the mutations. SH2 domain of the STAT3 gene is frequently mutated in Asian T cell large granular lymphocyte leukemia and chronic lymphoproliferative disorders of NK cells. Pure red cell aplasia is closely associated with the mutations."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ishida,  Fumihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Kazuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6447", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sekiguchi,  Nodoka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6448", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Makishima,  Hideki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6449", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taira,  Chiaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6450", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Momose,  Kayoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6451", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishina,  Sayaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6452", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Senoo,  Noriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6453", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai,  Hitoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6454", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito,  Toshiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6455", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kwong,  Yok-Lam", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6456", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "STAT3_gene_mutations_their_association.pdf", "filesize": [{"value": "754.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 754000.0, "url": {"label": "STAT3_gene_mutations_their_association.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3699/files/STAT3_gene_mutations_their_association.pdf"}, "version_id": "f6482b52-78dd-4ba4-8207-39b55cb02cee"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cytotoxic T cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "large granular lymphocyte leukemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "natural killer cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pure red cell aplasia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "STAT3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/17697", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-07-09"}, "publish_date": "2014-07-09", "publish_status": "0", "recid": "3699", "relation": {}, "relation_version_is_last": true, "title": ["STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia"], "weko_shared_id": -1}