Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-07-09 |
タイトル |
|
|
タイトル |
STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia |
言語 |
|
|
言語 |
eng |
DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/cas.12341 |
|
|
関連名称 |
10.1111/cas.12341 |
キーワード |
|
|
主題 |
Cytotoxic T cell, large granular lymphocyte leukemia, natural killer cell, pure red cell aplasia, STAT3 |
資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
著者 |
Ishida, Fumihiro
Matsuda, Kazuyuki
Sekiguchi, Nodoka
Makishima, Hideki
Taira, Chiaki
Momose, Kayoko
Nishina, Sayaka
Senoo, Noriko
Sakai, Hitoshi
Ito, Toshiro
Kwong, Yok-Lam
|
信州大学研究者総覧へのリンク |
|
|
氏名 |
Ishida, Fumihiro |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ueTCHhkh.html |
信州大学研究者総覧へのリンク |
|
|
氏名 |
Sekiguchi, Nodoka |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yNTUbhym.html |
出版者 |
|
|
出版者 |
WILEY-BLACKWELL |
引用 |
|
|
内容記述 |
CANCER SCIENCE. 105(3):342-346 (2014) |
書誌情報 |
CANCER SCIENCE
巻 105,
号 3,
p. 342-346,
発行日 2014-03
|
抄録 |
|
|
内容記述 |
Large granular lymphocyte leukemia (LGLL) has been morphologically characterized as a group of lymphoproliferative diseases that include T-cell large granular lymphocytic leukemia (T-LGLL) and chronic lymphoproliferative disorders of natural killer cells (CLPD-NK). We investigated mutations in the Src homology 2 (SH2) domain of the signal transducer and activator of transcription 3 (STAT3) gene in Asian cohorts of T-LGLL and CLPD-NK (n=42 and 11, respectively). Two mutations, Y640F and D661Y, were identified using direct sequencing or allele-specific (AS) PCR. Y640F and D661Y mutations were found in seven and 18 patients, respectively. Two patients were positive for both mutations. Frequencies of STAT3 mutations in T-LGLL and CLPD-NK were 47.6% and 27.2%, respectively. Pure red cell aplasia (PRCA) was associated with the mutations (P=0.005). The mutations were persistently found at stable levels in some patients after more than 5years using AS-quantitative PCR. The results of the present study indicate that the SH2 domain of the STAT3 gene is frequently mutated in Asian T-LGLL and CLPD-NK, and that PRCA is closely correlated with the mutations. SH2 domain of the STAT3 gene is frequently mutated in Asian T cell large granular lymphocyte leukemia and chronic lymphoproliferative disorders of NK cells. Pure red cell aplasia is closely associated with the mutations. |
資源タイプ(コンテンツの種類) |
|
|
内容記述 |
Article |
ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1349-7006 |
書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12100165 |
PubMed |
|
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/24350896 |
|
|
関連名称 |
24350896 |
権利 |
|
|
権利情報 |
Copyright© 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. |
出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000333670000013 |