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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes

http://hdl.handle.net/10091/17692
http://hdl.handle.net/10091/17692
787f00e4-2e93-46ae-9f2b-e0248080fbe7
名前 / ファイル ライセンス アクション
Pivotal_roles_shear_stress_microenvironmental.pdf Pivotal_roles_shear_stress_microenvironmental.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-09
タイトル
言語 en
タイトル Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kawai, Yoshiko

× Kawai, Yoshiko

WEKO 6457

en Kawai, Yoshiko

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Kaidoh, Maki

× Kaidoh, Maki

WEKO 6458

en Kaidoh, Maki

Search repository
Yokoyama, Yumiko

× Yokoyama, Yumiko

WEKO 6459

en Yokoyama, Yumiko

Search repository
Ohhashi, Toshio

× Ohhashi, Toshio

WEKO 6460

en Ohhashi, Toshio

Search repository
信州大学研究者総覧へのリンク
氏名 Kawai, Yoshiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uCDFuakh.html
信州大学研究者総覧へのリンク
氏名 Ohhashi, Toshio
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFApOFkh.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 CANCER SCIENCE. 103(7):1245-1252 (2012)
書誌情報 CANCER SCIENCE

巻 103, 号 7, p. 1245-1252, 発行日 2012-07
抄録
内容記述タイプ Abstract
内容記述 A sentinel lymph node (SLN) is the first lymph node that receives drainage from a primary tumor. According to their physiological and biomechanical characteristics, we hypothesized that SLN contains lymphatic endothelial cells (LEC) that are constantly loaded with high levels of shear stress, which might contribute to the production of a suitable environment for micrometastasis within them. To test this hypothesis, we investigated the effects of shear stress stimulation on the expression of adhesion molecules on human LEC isolated from the lymph vessels nearest the SLN of breast cancers, and on the release of ATP from human LEC. The study clarified that the shear stress stimulation produced a significant increase of ICAM-1 expression at protein and mRNA levels in human LEC. Next, we examined whether the shear stress-mediated increase of ICAM-1 expression accelerates the attachment of carcinoma cells to human LEC. Finally, in in vivo experiments, we evaluated whether exogenous ATP facilitates the expression of carcinoma cell-ligated adhesion molecules in rat SLN. In conclusion, shear stress stimulation induces ICAM-1 expression on human LEC by activating cell surface F1/FO ATP synthase, which might contribute to the development of a premetastatic environment within SLN. (Cancer Sci 2012; 103: 12451252)
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1347-9032
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11808050
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22463128
関連名称 22463128
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1349-7006.2012.02289.x
関連名称 10.1111/j.1349-7006.2012.02289.x
権利
権利情報 Copyright© 2012 Japanese Cancer Association.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000305888800012
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