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Essential Function of Protein 4.1G in Targeting of Membrane Protein Palmitoylated 6 into Schmidt-Lanterman Incisures in Myelinated Nerves
http://hdl.handle.net/10091/17621
http://hdl.handle.net/10091/176216840b3a9-e45a-4d47-bbe2-f57a1243bb12
| 名前 / ファイル | ライセンス | アクション |
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Essential_function_protein_4.1G_targeting.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-06-20 | |||||
| タイトル | ||||||
| タイトル | Essential Function of Protein 4.1G in Targeting of Membrane Protein Palmitoylated 6 into Schmidt-Lanterman Incisures in Myelinated Nerves | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 関連識別子 | https://doi.org/10.1128/MCB.05945-11 | |||||
| 関連名称 | 10.1128/MCB.05945-11 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Terada, Nobuo
× Terada, Nobuo× Saitoh, Yurika× Ohno, Nobuhiko× Komada, Masayuki× Saitoh, Sei× Peles, Elior× Ohno, Shinichi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Terada, Nobuo | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jVACPFSa.html | |||||
| 出版者 | ||||||
| 出版者 | AMER SOC MICROBIOLOGY | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | MOLECULAR AND CELLULAR BIOLOGY. 32(1):199-205 (2012) | |||||
| 書誌情報 |
MOLECULAR AND CELLULAR BIOLOGY 巻 32, 号 1, p. 199-205, 発行日 2012-01 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Protein 4.1G is a membrane skeletal protein found in specific subcellular structures in myelinated Schwann cells and seminiferous tubules. Here, we show that in the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6 (MPP6). Coimmunoprecipitation experiments revealed that MPP6 was interacting with protein 4.1G. In contrast to wild-type nerves, in 4.1G knockout mice, MPP6 was found largely in the cytoplasm near Schwann cell nuclei, indicating an abnormal protein transport. Although the SLI remained in the 4.1G knockout sciatic nerves, as confirmed by E-cadherin immunostaining, their shape was altered in aged 4.1G knockout nerves compared to their shape in wild-type nerves. In the seminiferous tubules, MPP6 was localized similarly to protein 4.1G along cell membranes of the spermatogonium and early spermatocytes. However, in contrast to myelinated peripheral nerves, the specific localization of MPP6 in the seminiferous tubules was unaltered in the absence of protein 4.1G. These results indicate that 4.1G has a specific role in the targeting of MPP6 to the SLI and the assembly of these subcellular structures. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0270-7306 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620925 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22025680 | |||||
| 関連名称 | 22025680 | |||||
| 権利 | ||||||
| 権利情報 | Copyright© 2012 American Society for Microbiology. | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000298366000017 | |||||
