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Expression of Various Glutamate Receptors Including N-Methyl-D-Aspartate Receptor (NMDAR) in an Ovarian Teratoma Removed from a Young Woman with Anti-NMDAR Encephalitis
http://hdl.handle.net/10091/17615
http://hdl.handle.net/10091/1761597487696-bd48-4823-8425-2949d62986a7
| 名前 / ファイル | ライセンス | アクション |
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Expression_Various_Glutamate_Receptors_Including_N-Methyl-D-Aspartate.pdf (560.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2014-06-20 | |||||||||||||||||||||
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| タイトル | Expression of Various Glutamate Receptors Including N-Methyl-D-Aspartate Receptor (NMDAR) in an Ovarian Teratoma Removed from a Young Woman with Anti-NMDAR Encephalitis | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.2169/internalmedicine.49.4069 | |||||||||||||||||||||
| 関連名称 | 10.2169/internalmedicine.49.4069 | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | limbic encephalitis, paraneoplastic syndrome, ovarian teratoma, glutamate receptor, N-methyl-D-aspartate receptor (NMDAR) | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||
| 著者 |
Tachibana, Naoko
× Tachibana, Naoko
× Shirakawa, Takashi
× Ishii, Keiko
× Takahashi, Yukitoshi
× Tanaka, Keiko
× Arima, Kunimasa
× Yoshida, Takuhiro
× Ikeda, Shu-ichi
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| 出版者 | ||||||||||||||||||||||
| 出版者 | JAPAN SOC INTERNAL MEDICINE | |||||||||||||||||||||
| 引用 | ||||||||||||||||||||||
| 内容記述 | INTERNAL MEDICINE. 49(19):2167-2173 (2010) | |||||||||||||||||||||
| 書誌情報 |
INTERNAL MEDICINE 巻 49, 号 19, p. 2167-2173, 発行日 2010 |
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| 抄録 | ||||||||||||||||||||||
| 内容記述 | A 21-year-old woman developed psychiatric symptoms, progressive unresponsiveness, generalized seizures, severe dyskinesia, marked fluctuation of blood pressure, and hypersalivation after a flu-like episode. Anti-glutamate receptor (GluR)epsilon 2 and anti-N-methyl-D-aspartate receptor (NMDAR) antibodies were positive in both her serum and CSF. After she recovered five months later she underwent surgery to remove a right ovarian teratoma. Immunohistochemical examinations of her teratoma disclosed abundant expression of various GluRs including NR2B subunit of NMDAR, GluR1, and GluR2/3. These immunoreactivities of GluRs were seen not only in small areas of neural tissue identified as anti-glial fibrillary acidic protein (GFAP)-immunoreactive areas but also in other large areas of undifferentiated neuroepithelial tissue without GFAP immunoreactivity. Our findings strongly support the recent idea that neural elements in ovarian teratoma play an important role in the production of antibodies to NMDARs in anti-NMDAR encephalitis. Additionally, the study of control ovaries clearly showed NR2B-related immunoreactivity in the cytoplasm of oocytes, indicating that the normal ovary itself has expression of NMDARs. This finding might provide a clue to understand the pathogenesis of this disease in female patients without ovarian teratoma. | |||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 0918-2918 | |||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA10827774 | |||||||||||||||||||||
| PubMed | ||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20930449 | |||||||||||||||||||||
| 関連名称 | 20930449 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | Copyright© 2010 The Japanese Society of Internal Medicine | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000283717600024 | |||||||||||||||||||||
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Tachibana, Naoko, Shirakawa, Takashi, Ishii, Keiko, Takahashi, Yukitoshi, Tanaka, Keiko, Arima, Kunimasa, Yoshida, Takuhiro, Ikeda, Shu-ichi, 2010, Expression of Various Glutamate Receptors Including N-Methyl-D-Aspartate Receptor (NMDAR) in an Ovarian Teratoma Removed from a Young Woman with Anti-NMDAR Encephalitis: JAPAN SOC INTERNAL MEDICINE, 2167–2173 p.
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