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  1. 050 医学部, 大学院医学系研究科 (Faculty&Graduate School of Medicine)
  2. 0501 学術論文 (Journal Articles)

Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators

http://hdl.handle.net/10091/17607
d23e2ce7-c460-4160-b12c-3d514011eaee
プレビュー
名前 / ファイル ライセンス Actions
Additive_efficacy_of_short-acting_bronchodilators_on_dynamic_hyperinflation.pdf Additive_efficacy_of_short-acting_bronchodilators_on_dynamic_hyperinflation.pdf (504.7 kB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-17
タイトル
タイトル Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators
言語
言語 eng
キーワード
主題 COPD
キーワード
主題 Dynamic hyperinflation
キーワード
主題 Exercise tolerance
キーワード
主題 Short-acting beta 2-agonists
キーワード
主題 Long-acting
キーワード
主題 Muscarinic antagonists
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kitaguchi, Yoshiaki

× Kitaguchi, Yoshiaki

WEKO 6608

Kitaguchi, Yoshiaki

Search repository
Fujimoto, Keisaku

× Fujimoto, Keisaku

WEKO 6609

Fujimoto, Keisaku

Search repository
Komatsu, Yoshimichi

× Komatsu, Yoshimichi

WEKO 6610

Komatsu, Yoshimichi

Search repository
Hanaoka, Masayuki

× Hanaoka, Masayuki

WEKO 6611

Hanaoka, Masayuki

Search repository
Honda, Takayuki

× Honda, Takayuki

WEKO 6612

Honda, Takayuki

Search repository
Kubo, Keishi

× Kubo, Keishi

WEKO 6613

Kubo, Keishi

Search repository
信州大学研究者総覧へのリンク
Fujimoto, Keisaku
http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html
信州大学研究者総覧へのリンク
Hanaoka, Masayuki
http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html
信州大学研究者総覧へのリンク
Honda, Takayuki
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDUHFkh.html
出版者
出版者 W B SAUNDERS CO LTD
引用
内容記述タイプ Other
内容記述 RESPIRATORY MEDICINE. 107(3):394-400 (2013)
書誌情報 RESPIRATORY MEDICINE

巻 107, 号 3, p. 394-400, 発行日 2013-03
抄録
内容記述タイプ Abstract
内容記述 The purpose of this study was to clarify the additive efficacy of short-acting beta(2)-agonists (SABA) or muscarinic antagonists (SAMA) on dynamic hyperinflation and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) who had been treated with long-acting bronchodilators. Thirty-two patients with stable COPD who had been treated with long-acting bronchodilators, including long-acting muscarinic antagonists (LAMA), were examined by pulmonary function tests, dynamic hyperinflation evaluated by the method of step-wise metronome-paced incremental hyperventilation, and the incremental shuttle walking test before and after inhalation of SABA or SAMA. The additive efficacy of the two drugs was analyzed. Inhalation of SABA and SAMA improved airflow limitation and dynamic hyperinflation in stable COPD patients who had been treated with LAMA. Inhalation of SABA decreased respiratory resistance and the difference in respiratory resistance at 5 Hz and 20 Hz. On the whole, the additive efficacy of SABA on airflow limitation and dynamic hyperinflation was superior to that of SAMA. Furthermore, inhalation of SABA resulted in relief of breathlessness during exercise and significant improvement in exercise capacity. Inhalation of SABA resulted in significant improvement in exercise tolerance, which may have been due to improvement in dynamic hyperinflation. Single use of SABA before exercise, in addition to regular treatment with LAMA, may therefore be useful in stable COPD patients.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0954-6111
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10699492
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=23245993
関連名称
関連名称 23245993
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.rmed.2012.11.013
関連名称
関連名称 10.1016/j.rmed.2012.11.013
権利
権利情報 Copyright© 2012 Elsevier Ltd.
著者版フラグ
値 author
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000316163200009
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