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Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators
http://hdl.handle.net/10091/17607
http://hdl.handle.net/10091/17607d23e2ce7-c460-4160-b12c-3d514011eaee
名前 / ファイル | ライセンス | アクション |
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Additive_efficacy_of_short-acting_bronchodilators_on_dynamic_hyperinflation.pdf (504.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Additive efficacy of short-acting bronchodilators on dynamic hyperinflation and exercise tolerance in stable COPD patients treated with long-acting bronchodilators | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.rmed.2012.11.013 | |||||
関連名称 | 10.1016/j.rmed.2012.11.013 | |||||
キーワード | ||||||
主題 | COPD, Dynamic hyperinflation, Exercise tolerance, Short-acting beta 2-agonists, Long-acting, Muscarinic antagonists | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kitaguchi, Yoshiaki
× Kitaguchi, Yoshiaki× Fujimoto, Keisaku× Komatsu, Yoshimichi× Hanaoka, Masayuki× Honda, Takayuki× Kubo, Keishi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Fujimoto, Keisaku | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Hanaoka, Masayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Honda, Takayuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDUHFkh.html | |||||
出版者 | ||||||
出版者 | W B SAUNDERS CO LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | RESPIRATORY MEDICINE. 107(3):394-400 (2013) | |||||
書誌情報 |
RESPIRATORY MEDICINE 巻 107, 号 3, p. 394-400, 発行日 2013-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to clarify the additive efficacy of short-acting beta(2)-agonists (SABA) or muscarinic antagonists (SAMA) on dynamic hyperinflation and exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) who had been treated with long-acting bronchodilators. Thirty-two patients with stable COPD who had been treated with long-acting bronchodilators, including long-acting muscarinic antagonists (LAMA), were examined by pulmonary function tests, dynamic hyperinflation evaluated by the method of step-wise metronome-paced incremental hyperventilation, and the incremental shuttle walking test before and after inhalation of SABA or SAMA. The additive efficacy of the two drugs was analyzed. Inhalation of SABA and SAMA improved airflow limitation and dynamic hyperinflation in stable COPD patients who had been treated with LAMA. Inhalation of SABA decreased respiratory resistance and the difference in respiratory resistance at 5 Hz and 20 Hz. On the whole, the additive efficacy of SABA on airflow limitation and dynamic hyperinflation was superior to that of SAMA. Furthermore, inhalation of SABA resulted in relief of breathlessness during exercise and significant improvement in exercise capacity. Inhalation of SABA resulted in significant improvement in exercise tolerance, which may have been due to improvement in dynamic hyperinflation. Single use of SABA before exercise, in addition to regular treatment with LAMA, may therefore be useful in stable COPD patients. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0954-6111 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10699492 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/23245993 | |||||
関連名称 | 23245993 | |||||
権利 | ||||||
権利情報 | Copyright© 2012 Elsevier Ltd. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000316163200009 |