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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease

http://hdl.handle.net/10091/17605
8878a007-2d50-4a55-b030-83915640bd8f
名前 / ファイル ライセンス アクション
gamma-Secretase-Regulated_Mechanisms_Similar_Notch_Signaling.pdf gamma-Secretase-Regulated_Mechanisms_Similar_Notch_Signaling.pdf (636.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-17
タイトル
言語 en
タイトル γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease
言語
言語 eng
キーワード
主題Scheme Other
主題 Alzheimer's disease
キーワード
主題Scheme Other
主題 gamma-Secretase
キーワード
主題Scheme Other
主題 Amyloid precursor protein
キーワード
主題Scheme Other
主題 Notch signaling
キーワード
主題Scheme Other
主題 Intracellular domain
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakayama, Kohzo

× Nakayama, Kohzo

WEKO 6617

en Nakayama, Kohzo

Search repository
Nagase, Hisashi

× Nagase, Hisashi

WEKO 6618

en Nagase, Hisashi

Search repository
Koh, Chang-Sung

× Koh, Chang-Sung

WEKO 6619

en Koh, Chang-Sung

Search repository
Ohkawara, Takeshi

× Ohkawara, Takeshi

WEKO 6620

en Ohkawara, Takeshi

Search repository
信州大学研究者総覧へのリンク
氏名 Nagase, Hisashi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jFfauUkh.html
出版者
出版者 SPRINGER/PLENUM PUBLISHERS
引用
内容記述タイプ Other
内容記述 CELLULAR AND MOLECULAR NEUROBIOLOGY. 31(6):887-900 (2011)
書誌情報 CELLULAR AND MOLECULAR NEUROBIOLOGY

巻 31, 号 6, p. 887-900, 発行日 2011-08
抄録
内容記述タイプ Abstract
内容記述 Although gamma-secretase was first identified as a protease that cleaves amyloid precursor protein (APP) within the transmembrane domain, thus producing A beta peptides that are thought to be pathogenic in Alzheimer's disease (AD), its physiological functions have not been fully elucidated. In the canonical Notch signaling pathway, intramembrane cleavage by gamma-secretase serves to release an intracellular domain of Notch that shows activity in the nucleus through binding to transcription factors. Many type 1 transmembrane proteins, including Notch, Delta, and APP, have recently been shown to be substrates for gamma-secretase, and their intracellular domains are released from the cell membrane following cleavage by gamma-secretase. The common enzyme gamma-secretase modulates proteolysis and the turnover of possible signaling molecules, which has led to the attractive hypothesis that mechanisms similar to Notch signaling contribute widely to proteolysis-regulated signaling pathways. APP is also likely to have a signaling mechanism, although the physiological functions of APP have not been elucidated. Indeed, we have shown that the intracellular domain of APP alters gene expression and induces neuron-specific apoptosis. These results suggest that APP signaling responds to the onset of AD. Here, we review the possibility of gamma-secretase-regulated signaling, including APP signaling, which leads to AD.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0272-4340
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10622352
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21516353
関連名称
関連名称 21516353
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10571-011-9688-z
関連名称
関連名称 10.1007/s10571-011-9688-z
権利
権利情報 The final publication is available at www.springerlink.com
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000293325300011
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