Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-06-17 |
タイトル |
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タイトル |
γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1007/s10571-011-9688-z |
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関連名称 |
10.1007/s10571-011-9688-z |
キーワード |
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主題 |
Alzheimer's disease, gamma-Secretase, Amyloid precursor protein, Notch signaling, Intracellular domain |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Nakayama, Kohzo
Nagase, Hisashi
Koh, Chang-Sung
Ohkawara, Takeshi
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信州大学研究者総覧へのリンク |
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氏名 |
Nagase, Hisashi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jFfauUkh.html |
出版者 |
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出版者 |
SPRINGER/PLENUM PUBLISHERS |
引用 |
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内容記述 |
CELLULAR AND MOLECULAR NEUROBIOLOGY. 31(6):887-900 (2011) |
書誌情報 |
CELLULAR AND MOLECULAR NEUROBIOLOGY
巻 31,
号 6,
p. 887-900,
発行日 2011-08
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抄録 |
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内容記述 |
Although gamma-secretase was first identified as a protease that cleaves amyloid precursor protein (APP) within the transmembrane domain, thus producing A beta peptides that are thought to be pathogenic in Alzheimer's disease (AD), its physiological functions have not been fully elucidated. In the canonical Notch signaling pathway, intramembrane cleavage by gamma-secretase serves to release an intracellular domain of Notch that shows activity in the nucleus through binding to transcription factors. Many type 1 transmembrane proteins, including Notch, Delta, and APP, have recently been shown to be substrates for gamma-secretase, and their intracellular domains are released from the cell membrane following cleavage by gamma-secretase. The common enzyme gamma-secretase modulates proteolysis and the turnover of possible signaling molecules, which has led to the attractive hypothesis that mechanisms similar to Notch signaling contribute widely to proteolysis-regulated signaling pathways. APP is also likely to have a signaling mechanism, although the physiological functions of APP have not been elucidated. Indeed, we have shown that the intracellular domain of APP alters gene expression and induces neuron-specific apoptosis. These results suggest that APP signaling responds to the onset of AD. Here, we review the possibility of gamma-secretase-regulated signaling, including APP signaling, which leads to AD. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0272-4340 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10622352 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21516353 |
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関連名称 |
21516353 |
権利 |
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権利情報 |
The final publication is available at www.springerlink.com |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000293325300011 |