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γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease
http://hdl.handle.net/10091/17605
http://hdl.handle.net/10091/176058878a007-2d50-4a55-b030-83915640bd8f
名前 / ファイル | ライセンス | アクション |
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gamma-Secretase-Regulated_Mechanisms_Similar_Notch_Signaling.pdf (636.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-06-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Alzheimer's disease, gamma-Secretase, Amyloid precursor protein, Notch signaling, Intracellular domain | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Nakayama, Kohzo
× Nakayama, Kohzo× Nagase, Hisashi× Koh, Chang-Sung× Ohkawara, Takeshi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nagase, Hisashi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jFfauUkh.html | |||||
出版者 | ||||||
出版者 | SPRINGER/PLENUM PUBLISHERS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CELLULAR AND MOLECULAR NEUROBIOLOGY. 31(6):887-900 (2011) | |||||
書誌情報 |
CELLULAR AND MOLECULAR NEUROBIOLOGY 巻 31, 号 6, p. 887-900, 発行日 2011-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although gamma-secretase was first identified as a protease that cleaves amyloid precursor protein (APP) within the transmembrane domain, thus producing A beta peptides that are thought to be pathogenic in Alzheimer's disease (AD), its physiological functions have not been fully elucidated. In the canonical Notch signaling pathway, intramembrane cleavage by gamma-secretase serves to release an intracellular domain of Notch that shows activity in the nucleus through binding to transcription factors. Many type 1 transmembrane proteins, including Notch, Delta, and APP, have recently been shown to be substrates for gamma-secretase, and their intracellular domains are released from the cell membrane following cleavage by gamma-secretase. The common enzyme gamma-secretase modulates proteolysis and the turnover of possible signaling molecules, which has led to the attractive hypothesis that mechanisms similar to Notch signaling contribute widely to proteolysis-regulated signaling pathways. APP is also likely to have a signaling mechanism, although the physiological functions of APP have not been elucidated. Indeed, we have shown that the intracellular domain of APP alters gene expression and induces neuron-specific apoptosis. These results suggest that APP signaling responds to the onset of AD. Here, we review the possibility of gamma-secretase-regulated signaling, including APP signaling, which leads to AD. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0272-4340 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10622352 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21516353 | |||||
関連名称 | 21516353 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10571-011-9688-z | |||||
関連名称 | 10.1007/s10571-011-9688-z | |||||
権利 | ||||||
権利情報 | The final publication is available at www.springerlink.com | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000293325300011 |