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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure

http://hdl.handle.net/10091/17602
http://hdl.handle.net/10091/17602
7e8a499f-7013-47ac-8216-f4d284f7f937
名前 / ファイル ライセンス アクション
beta2-Adrenergic_M-2-muscarinic_receptors_decrease_basal.pdf beta2-Adrenergic_M-2-muscarinic_receptors_decrease_basal.pdf (14.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-12
タイトル
言語 en
タイトル β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
言語
言語 eng
キーワード
主題Scheme Other
主題 Heart failure
キーワード
主題Scheme Other
主題 L-type Ca2+ channels
キーワード
主題Scheme Other
主題 Protein phosphatase
キーワード
主題Scheme Other
主題 beta(2)-adrenergic receptor
キーワード
主題Scheme Other
主題 M-2-muscarinic receptor
キーワード
主題Scheme Other
主題 A(1)-adenosine receptor
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kashihara, Toshihide

× Kashihara, Toshihide

WEKO 6636

en Kashihara, Toshihide

Search repository
Hirose, Masamichi

× Hirose, Masamichi

WEKO 6637

en Hirose, Masamichi

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Shimojo, Hisashi

× Shimojo, Hisashi

WEKO 6638

en Shimojo, Hisashi

Search repository
Nakada, Tsutomu

× Nakada, Tsutomu

WEKO 6639

en Nakada, Tsutomu

Search repository
Gomi, Simmon

× Gomi, Simmon

WEKO 6640

en Gomi, Simmon

Search repository
Hongo, Minoru

× Hongo, Minoru

WEKO 6641

en Hongo, Minoru

Search repository
Yamada, Mitsuhiko

× Yamada, Mitsuhiko

WEKO 6642

en Yamada, Mitsuhiko

Search repository
信州大学研究者総覧へのリンク
氏名 Nakada, Tsutomu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html
信州大学研究者総覧へのリンク
氏名 Yamada, Mitsuhiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html
出版者
出版者 ELSEVIER SCIENCE BV
引用
内容記述タイプ Other
内容記述 EUROPEAN JOURNAL OF PHARMACOLOGY. 724:122-131 (2014)
書誌情報 EUROPEAN JOURNAL OF PHARMACOLOGY

巻 724, p. 122-131, 発行日 2014-02-05
抄録
内容記述タイプ Abstract
内容記述 L-Lype Ca2+ channels (LTCC) play a crucial role in cardiac excitation-contraction coupling. We previously found that in failing ventricular myocytes of mice chronically treated with isoproterenol, basal t-tubular (TT) LTCC activity was halved by activation of protein phosphatase (PP)2A whereas basal surface sarcolemmal (SS) LTCC activity was doubled by inhibition of PP1. Interestingly, chronic treatment of these mice with pertussis toxin almost completely normalized TT and SS LTCC densities and cardiac contractility. In the present study, we therefore sought to identify the G(i/o) protein coupled receptors in cardiac myocytes (i.e. beta(2)-adrenergic, M-2-muscarinic and A(1)-adenosine receptors) that are responsible for these abnormalities in heart failure by chronically administrating mice a selective antagonist of each receptor (ICI118,551, atropine and 8-cyclopentyl-1,3-dipropilxanthine (DPCPX), respectively) with isoproterenol. Compared with mice treated with isoproterenol alone, mice treated with isoproterenol plus ICI118,551 or atropine, but not DPCPX showed significantly lower lung weight/tibial length, higher fractional shortening, lower left ventricular end-diastolic pressure and higher dP/dt(max) and dP/dt(min). In addition, ventricular myocytes of mice treated with isoproterenol plus ICI118,551 or atropine, but not DPCPX exhibited significantly higher TT and lower SS LTCC current densities than those of mice treated with isoproterenol alone due to normalization of the PP activities. These results indicate that beta(2)-adrenergic, M-2-muscarinic, but not A(1)-adenosine receptors contribute to reduced ventricular contractility at least partially by decreasing basal TT LTCC activity in heart failure. Therefore, antagonists of beta(2)-alrenergic and/or M-2-muscarinic receptors can be good adjuncts to beta(1)-adrenergic receptor antagonists in the treatment of heart failure.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0014-2999
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00639687
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24389135
関連名称 24389135
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ejphar.2013.12.037
関連名称 10.1016/j.ejphar.2013.12.037
権利
権利情報 Copyright© 2013 Elsevier B.V.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000331140500015
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