Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-06-10 |
タイトル |
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タイトル |
Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1 |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.febslet.2012.05.029 |
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関連名称 |
10.1016/j.febslet.2012.05.029 |
キーワード |
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主題 |
LMP2, Calponin h1, Uterine leiomyosarcoma, Cell morphology |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Hayashi, Takuma
Horiuchi, Akiko
Sano, Kenji
Hiraoka, Nobuyoshi
Kasai, Mari
Ichimura, Tomoyuki
Sudo, Tamotsu
Nishimura, Ryuichiro
Ishiko, Osamu
Shiozawa, Tanri
Kanai, Yae
Yaegashi, Nobuo
Aburatani, Hiroyuki
Konishi, Ikuo
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信州大学研究者総覧へのリンク |
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氏名 |
Shiozawa, Tanri |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html |
出版者 |
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出版者 |
ELSEVIER SCIENCE BV |
引用 |
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内容記述 |
FEBS LETTERS. 586(13):1824-1831 (2012) |
書誌情報 |
FEBS LETTERS
巻 586,
号 13,
p. 1824-1831,
発行日 2012-06-21
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抄録 |
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内容記述 |
Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0014-5793 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00642943 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/22659265 |
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関連名称 |
22659265 |
権利 |
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権利情報 |
Copyright© 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000305405000013 |