ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "7527fcc0-19fe-4c99-9f51-dc43be1d0c44"}, "_deposit": {"id": "3744", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3744"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003744", "sets": ["461:462"]}, "author_link": ["6748", "6749", "6750", "6751", "6752", "6753", "6754", "6755", "6756", "6757", "6758", "6759", "6760", "6761", "6762"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-12-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "180", "bibliographicVolumeNumber": "1", "bibliographic_titles": [{"bibliographic_title": "SCIENTIFIC REPORTS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-gamma-inducible factor, spontaneously develop uterine LMS. The IFN-gamma pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tissues revealed a defective LMP2 expression in human uterine LMS that was traced to the IFN-gamma pathway and the specific effect of JAK-1 somatic mutations on the LMP2 transcriptional activation. Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. This role of LMP2 as a tumor suppressor may lead to new therapeutic targets in human uterine LMS.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "SCIENTIFIC REPORTS. 1:180 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Shiozawa, Tanri", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000300562400001"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "NATURE PUBLISHING GROUP"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "22355695"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/22355695", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/srep00180"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/srep00180", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "EISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "NF-KAPPA-B; PROTEASOME SUBUNITS; MUTATIONAL ANALYSIS; COLORECTAL CANCERS; KINASE MUTATIONS; GENE-EXPRESSION; SARCOMAS; SURVIVAL; PATHWAY; UTERUS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-gamma-inducible factor, spontaneously develop uterine LMS. The IFN-gamma pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tissues revealed a defective LMP2 expression in human uterine LMS that was traced to the IFN-gamma pathway and the specific effect of JAK-1 somatic mutations on the LMP2 transcriptional activation. Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. This role of LMP2 as a tumor suppressor may lead to new therapeutic targets in human uterine LMS."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi,  Takuma", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6748", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horiuchi,  Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6749", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sano,  Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6750", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiraoka,  Nobuyoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6751", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kasai,  Mari", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6752", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichimura,  Tomoyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6753", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sudo,  Tamotsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6754", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagawa,  Yoh-ichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6755", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimura,  Ryuichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6756", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiko,  Osamu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6757", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanai,  Yae", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6758", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yaegashi,  Nobuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6759", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aburatani,  Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6760", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiozawa,  Tanri", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Konishi,  Ikuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6762", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Potential_role_LMP2_tumor-suppressor_defines.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "Potential_role_LMP2_tumor-suppressor_defines.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3744/files/Potential_role_LMP2_tumor-suppressor_defines.pdf"}, "version_id": "2dfd2059-68b3-4095-8bc8-bbdd2ae02ccb"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17584", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-06-10"}, "publish_date": "2014-06-10", "publish_status": "0", "recid": "3744", "relation": {}, "relation_version_is_last": true, "title": ["Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy

http://hdl.handle.net/10091/17584
9446d28e-6a7b-4e8f-b4dc-c95e0d90abb2
名前 / ファイル ライセンス アクション
Potential_role_LMP2_tumor-suppressor_defines.pdf Potential_role_LMP2_tumor-suppressor_defines.pdf (2.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-10
タイトル
言語 en
タイトル Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hayashi, Takuma

× Hayashi, Takuma

WEKO 6748

en Hayashi, Takuma

Search repository
Horiuchi, Akiko

× Horiuchi, Akiko

WEKO 6749

en Horiuchi, Akiko

Search repository
Sano, Kenji

× Sano, Kenji

WEKO 6750

en Sano, Kenji

Search repository
Hiraoka, Nobuyoshi

× Hiraoka, Nobuyoshi

WEKO 6751

en Hiraoka, Nobuyoshi

Search repository
Kasai, Mari

× Kasai, Mari

WEKO 6752

en Kasai, Mari

Search repository
Ichimura, Tomoyuki

× Ichimura, Tomoyuki

WEKO 6753

en Ichimura, Tomoyuki

Search repository
Sudo, Tamotsu

× Sudo, Tamotsu

WEKO 6754

en Sudo, Tamotsu

Search repository
Tagawa, Yoh-ichi

× Tagawa, Yoh-ichi

WEKO 6755

en Tagawa, Yoh-ichi

Search repository
Nishimura, Ryuichiro

× Nishimura, Ryuichiro

WEKO 6756

en Nishimura, Ryuichiro

Search repository
Ishiko, Osamu

× Ishiko, Osamu

WEKO 6757

en Ishiko, Osamu

Search repository
Kanai, Yae

× Kanai, Yae

WEKO 6758

en Kanai, Yae

Search repository
Yaegashi, Nobuo

× Yaegashi, Nobuo

WEKO 6759

en Yaegashi, Nobuo

Search repository
Aburatani, Hiroyuki

× Aburatani, Hiroyuki

WEKO 6760

en Aburatani, Hiroyuki

Search repository
Shiozawa, Tanri

× Shiozawa, Tanri

WEKO 6761

en Shiozawa, Tanri

Search repository
Konishi, Ikuo

× Konishi, Ikuo

WEKO 6762

en Konishi, Ikuo

Search repository
信州大学研究者総覧へのリンク
氏名 Shiozawa, Tanri
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 1:180 (2011)
書誌情報 SCIENTIFIC REPORTS

巻 1, p. 180, 発行日 2011-12-05
抄録
内容記述タイプ Abstract
内容記述 Although the majority of smooth muscle neoplasms found in the uterus are benign, uterine leiomyosarcoma (LMS) is extremely malignant, with high rates of recurrence and metastasis. We earlier reported that mice with a homozygous deficiency for LMP2, an interferon (IFN)-gamma-inducible factor, spontaneously develop uterine LMS. The IFN-gamma pathway is important for control of tumor growth and invasion and has been implicated in several cancers. In this study, experiments with human and mouse uterine tissues revealed a defective LMP2 expression in human uterine LMS that was traced to the IFN-gamma pathway and the specific effect of JAK-1 somatic mutations on the LMP2 transcriptional activation. Furthermore, analysis of a human uterine LMS cell line clarified the biological significance of LMP2 in malignant myometrium transformation and cell cycle, thus implicating LMP2 as an anti-tumorigenic candidate. This role of LMP2 as a tumor suppressor may lead to new therapeutic targets in human uterine LMS.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22355695
関連名称
関連名称 22355695
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep00180
関連名称
関連名称 10.1038/srep00180
権利
権利情報 This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000300562400001
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 08:57:22.242954
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio