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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Bone Marrow-Derived Cells Implanted into Radiation-Injured Urinary Bladders Reconstruct Functional Bladder Tissues in Rats

http://hdl.handle.net/10091/17583
a9c9d4a5-7068-49a4-84ad-6da3d59746ff
名前 / ファイル ライセンス アクション
Bone_Marrow-Derived_Cells_Implanted_Radiation-Injured.pdf Bone_Marrow-Derived_Cells_Implanted_Radiation-Injured.pdf (2.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-10
タイトル
言語 en
タイトル Bone Marrow-Derived Cells Implanted into Radiation-Injured Urinary Bladders Reconstruct Functional Bladder Tissues in Rats
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 6763

en Imamura, Tetsuya

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 6764

en Ishizuka, Osamu

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Lei, Zhang

× Lei, Zhang

WEKO 6765

en Lei, Zhang

Search repository
Hida, Shigeaki

× Hida, Shigeaki

WEKO 6766

en Hida, Shigeaki

Search repository
Sudha, Gautam Silwal

× Sudha, Gautam Silwal

WEKO 6767

en Sudha, Gautam Silwal

Search repository
Kato, Haruaki

× Kato, Haruaki

WEKO 6768

en Kato, Haruaki

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 6769

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Ishizuka, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 MARY ANN LIEBERT INC
引用
内容記述タイプ Other
内容記述 TISSUE ENGINEERING PART A. 18(15-16):1698-1709 (2012)
書誌情報 TISSUE ENGINEERING PART A

巻 18, 号 15-16, p. 1698-1709, 発行日 2012-08
抄録
内容記述タイプ Abstract
内容記述 The purpose of this study was to determine whether bone marrow-derived cells implanted into radiation-injured urinary bladders could reconstruct functional bladder tissues. The pelvic region of anesthetized female Sprague-Dawley (SD) rats was irradiated with 2 Gy once a week for 5 weeks. After the last irradiation, the rats were maintained for 2 weeks. Bone marrow cells were harvested from the femurs of donor male green fluorescence protein (GFP)-transfected SD rats and cultured for 7 days. Two weeks after the last radiation exposure, the cultured adherent, proliferating bone marrow-derived cells were implanted into the walls of irradiated urinary bladders. For controls, cell-free solutions were similarly injected. Four weeks after donor cell or control implantations, cystometric, histological, and immunohistochemical investigations were performed. Two weeks after the last irradiation, the smooth muscle layers and nerve fibers of the irradiated urinary bladders were disorganized. The proportions of smooth muscle layer and nerve fiber areas were significantly decreased compared with sham-irradiated urinary bladders. In addition, the remaining smooth muscle cells within the irradiated urinary bladders expressed P4HB, an indicator of collagen synthesis. In the cystometric investigations, the voiding interval of irradiated rats was irregularly prolonged, 7.92 +/- 1.09 min, and the residual volume, 0.13 +/- 0.03 mL, was significantly higher compared with the sham-irradiated rats (5.50 +/- 0.43mL and 0.05 +/- 0.01 mL). After 4 weeks, the smooth muscle layers and nerve fibers in the cell-free control urinary bladders remained similar to the pre-implanted irradiated urinary bladders; however, the cell-implanted urinary bladders contained reconstructed smooth muscle layers and nerve fibers, the proportions of each were significantly higher than those in the cell-free injected controls. The expression of P4HB within the cell-implanted urinary bladders decreased. Some GFP-positive implanted cells differentiated into smooth muscle-and nerve-like cells and became organized into the reconstructed tissues. The voiding interval of the cell-implanted rats, 5.46 +/- 0.33 min, was regular and similar to that of the sham-irradiated rats, and significantly less than that of the cell-free injected controls, 7.39 +/- 0.54 min. The residual volume, 0.04 +/- 0.01 mL, was similar to that of the sham-irradiated rats and significantly decreased compared with that of the cell-free injected controls, 0.15 +/- 0.05 mL. Therefore, the implantation of bone marrow-derived cells is a potentially useful treatment for radiotherapy-induced urinary dysfunctions.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1937-3341
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12306003
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22480258
関連名称
関連名称 22480258
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1089/ten.tea.2012.0061
関連名称
関連名称 10.1089/ten.tea.2012.0061
権利
権利情報 This is a copy of an article published in the Tissue Engineering Part A. Copyright© 2012 Mary Ann Liebert, Inc.; Tissue Engineering Part A is available online at: http://online.liebertpub.com.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000307999100016
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