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We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "PEDIATRIC RHEUMATOLOGY. 9:15 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Shigemura, Tomonari", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WVTNbhym.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000293948700001"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "BIOMED CENTRAL LTD"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21749729"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/21749729", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1186/1546-0096-9-15"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1186/1546-0096-9-15", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2011 Shigemura et al; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1546-0096", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1546-0096", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "IFN-GAMMA PRODUCTION; T-CELLS; INTERLEUKIN-18; CYTOKINE; DISEASE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shigemura,  Tomonari", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamazaki,  Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara,  Yosuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6809", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ou,  Jing-Ni", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6810", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Stevens,  Anne M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6811", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ochs,  Hans D", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6812", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koike,  Kenichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6813", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Agematsu,  Kazunaga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6814", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Monitoring_serum_IL-18_levels_useful.pdf", "filesize": [{"value": "296.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 296400.0, "url": {"label": "Monitoring_serum_IL-18_levels_useful.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3752/files/Monitoring_serum_IL-18_levels_useful.pdf"}, "version_id": "22fd6c7f-5459-4204-9c48-963cf8314cfa"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17572", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-06-09"}, "publish_date": "2014-06-09", "publish_status": "0", "recid": "3752", "relation": {}, "relation_version_is_last": true, "title": ["Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome"], "weko_shared_id": -1}