Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-01-21 |
タイトル |
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タイトル |
Clinical effects of stereotactic radiation surgery in patients with metastatic melanoma |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1111/1346-8138.12179 |
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関連名称 |
10.1111/1346-8138.12179 |
キーワード |
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主題 |
disease-free survival, gamma knife, melanoma, overall survival, stereotactic radiation surgery |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Mikoshiba, Asuka
Uhara, Hisashi
Murata, Hiroshi
Okuyama, Ryuhei
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信州大学研究者総覧へのリンク |
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氏名 |
Okuyama, Ryuhei |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZpfNHFSF.html |
出版者 |
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出版者 |
WILEY-BLACKWELL |
引用 |
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内容記述 |
JOURNAL OF DERMATOLOGY. 40(8):626-628 (2013) |
書誌情報 |
JOURNAL OF DERMATOLOGY
巻 40,
号 8,
p. 626-628,
発行日 2013-08
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抄録 |
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内容記述 |
We examined the effectiveness of stereotactic radiation surgery (SRS) in 14 patients with brain metastasis in our hospital. The age of the patients ranged 45-85 years old (mean, 65). Brain metastasis was detected by neurological symptoms in seven patients and by regular imaging examination in the remaining patients. The number of metastatic lesions in the brain before SRS ranged 1-11 (median, 2). The treatment number of SRS was 1-4 times (median, 2). Six of 14 patients had neurological symptoms before SRS. Overall survival (OS) after SRS was 1.721.2 months (median, 8.2). The progression-free survival (PFS) after SRS was 0.9-10.5 months (median, 2.2). The result of univariate analysis showed that the application of two or more courses of SRS was significantly related to OS (P = 0.005). Single metastatic lesion (P = 0.051) and no extracranial lesion (P = 0.055) showed a slight tendency to be related to disease-free survival (DFS). Neither lactate dehydrogenase nor neurological symptoms were significantly related to OS or DFS. Although OS and DFS after SRS were not very long, the treatment of brain metastases has the potential to prevent neurological events. Repeating SRS may be accepted as a local therapy in the multimodal approach including new molecular targeting drugs for metastatic melanoma. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-2407 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00696658 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/23682870 |
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関連名称 |
23682870 |
権利 |
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権利情報 |
Copyright© 2013 Japanese Dermatological Association |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326243600005 |