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Comparison of efficacy and safety of 1-and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer
http://hdl.handle.net/10091/17334
http://hdl.handle.net/10091/17334209ce535-8152-45d0-8bcc-6c17bcf0a64c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Comparison_efficacy_safety_1-and 3-month_luteinizing.pdf (192.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-01-21 | |||||
| タイトル | ||||||
| タイトル | Comparison of efficacy and safety of 1-and 3-month luteinizing hormone-releasing hormone agonist depots as initial therapies for prostate cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10147-012-0413-9 | |||||
| 関連名称 | 10.1007/s10147-012-0413-9 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prostate cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Androgen deprivation therapy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Luteinizing hormone-releasing hormone agonist | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ishizuka, Osamu
× Ishizuka, Osamu× Nishizawa, Osamu× Nishizawa, Shuji× Satoh, Tomoya× Wajiki, Masahisa× Kiyokawa, Hideo× Inoue, Yoshihiro× Kobayashi, Shinya× Mizusawa, Hiroya× Nakagawa, Tatsuo |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Ishizuka, Osamu | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nishizawa, Osamu | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||
| 出版者 | ||||||
| 出版者 | SPRINGER JAPAN KK | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY. 18(3):524-530 (2013) | |||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 巻 18, 号 3, p. 524-530, 発行日 2013-06 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We compared the efficacy and safety of 1- and 3-month depots of the luteinizing hormone-releasing hormone (LH-RH) agonist goserelin acetate in prostate cancer patients. Patients were randomly assigned to the Direct Group that received the goserelin 3-month depot or the Switch Group that began with the 1-month depot for the first 3 months and then switched to the 3-month depot. All patients were co-administered the antiandrogen agent bicalutamide. Serum testosterone and prostate-specific antigen (PSA) levels and adverse events were recorded at weeks 4, 8, 12, and 24. Baseline testosterone levels in the Direct and Switch Groups were 4.98 and 5.07 ng/mL, respectively (P = 0.798). At each week, the levels in both groups were a parts per thousand currency sign0.50 ng/mL (castration level) with no significant differences between them. All of the patients in the Switch Group and 98.1 % in the Direct Group had achieved castration levels at week 12, and 100 % had achieved such levels at week 24. Baseline PSA levels in the Direct and Switch Groups were 52.37 and 46.72 ng/mL, respectively (P = 0.793). Levels in both groups dropped continuously, to about 1.0 ng/mL at week 24, with no significant differences between the groups at any time. Three patients in the Direct Group experienced adverse events that were attributed to the co-administered bicalutamide. There was no difference in the efficacy or safety between the 1- and 3-month depots of goserelin when given as initial prostate cancer treatment in combination with bicalutamide. Patients must be monitored for adverse events associated with bicalutamide. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1341-9625 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11086579 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22552359 | |||||
| 関連名称 | 22552359 | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.springerlink.com | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000320456500025 | |||||
