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  1. 050 医学部, 大学院医学系研究科 (Faculty&Graduate School of Medicine)
  2. 0501 学術論文 (Journal Articles)

Role of Sulfated O-Glycans Expressed by High Endothelial Venule-Like Vessels in Pathogenesis of Chronic Inflammatory Gastrointestinal Diseases

http://hdl.handle.net/10091/16954
6a4a326a-efe5-4c63-9412-370295615330
プレビュー
名前 / ファイル ライセンス Actions
New_Era_Glycoscience_Intrinsic_Extrinsic_Functions.pdf New_Era_Glycoscience_Intrinsic_Extrinsic_Functions.pdf (4.3 MB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-23
タイトル
タイトル Role of Sulfated O-Glycans Expressed by High Endothelial Venule-Like Vessels in Pathogenesis of Chronic Inflammatory Gastrointestinal Diseases
言語
言語 eng
キーワード
主題 high endothelial venule
キーワード
主題 sulfated O-glycan
キーワード
主題 peripheral lymph node addressin
キーワード
主題 Helicobacter pylori
キーワード
主題 chronic gastritis
キーワード
主題 ulcerative colitis
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kobayashi, Motohiro

× Kobayashi, Motohiro

WEKO 7004

Kobayashi, Motohiro

Search repository
Fukuda, Minoru

× Fukuda, Minoru

WEKO 7005

Fukuda, Minoru

Search repository
Nakayama, Jun

× Nakayama, Jun

WEKO 7006

Nakayama, Jun

Search repository
信州大学研究者総覧へのリンク
Nakayama, Jun
http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html
出版者
出版者 PHARMACEUTICAL SOC JAPAN
引用
内容記述タイプ Other
内容記述 BIOLOGICAL & PHARMACEUTICAL BULLETIN. 32(5):774-779 (2009)
書誌情報 BIOLOGICAL & PHARMACEUTICAL BULLETIN

巻 32, 号 5, p. 774-779, 発行日 2009-05
抄録
内容記述タイプ Abstract
内容記述 Lymphocyte homing is mediated by a cascade of adhesive interactions between circulating lymphocytes and specialized endothelial cells comprising high endothelial venules (HEVs). Sulfated O-glycans expressed on HEVs, collectively called peripheral lymph node addressin (PNAd), interact with L-selectin expressed on lymphocytes, contributing to the initial step of the lymphocyte homing. In chronic inflammatory states, PNAd is induced on HEV-like vessels but absent in non-lymphoid tissues under normal conditions. Such HEV-like vessels have been observed in various chronic inflammatory diseases including rheumatoid arthritis, lymphocytic thyroiditis, Helicobacter pylori-associated chronic gastritis, and inflammatory bowel disease (IBD), and implicated in lymphocyte recruitment in those diseases. In H. pylori-associated chronic gastritis, PNAd-expressing HEV-like vessels are induced, and the progression of chronic inflammation is highly correlated with appearance of these vessels. Furthermore, eradication of H. pylori by antibiotics resulted in disappearance of PNAd. These results indicate that inhibition of PNAd formation could have therapeutic effect by attenuating lymphocyte recruitment. In ulcerative colitis (UC), PNAd-expressing HEV-like vessels are induced, preferentially in the active phase, and T cells, particularly CD4(+) T cells, are closely associated with these vessels, suggesting that T cell recruitment via PNAd-expressing HEV-like vessels plays at least a partial role in UC pathogenesis. Additionally, N-acetylglucosamine-6-O-sulfotransferase I (GlcNAc6ST-1) is suggested to be a candidate to regulate PNAd induction on HEV-like vessels in UC. These results provide a potential therapeutic strategy to treat UC by blocking T cell adhesion to PNAd-expressing HEV-like vessels. Inhibition or down-regulation of GlcNAc6ST-1 may be an alternative.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0918-6158
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10885497
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1248/bpb.32.774
関連名称
関連名称 10.1248/bpb.32.774
権利
権利情報 Copyright (C) 2009 The Pharmaceutical Society of Japan
著者版フラグ
値 publisher
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266047300003
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